The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex
Abstract
Immunophilins, a family of proteins that exhibit rotamase (peptidyl-prolyl cis-trans isomerase) activity in vitro, are expressed in many organisms and most tissues. Although some immunophilins can mediate the immunosuppressive actions of FK506, rapamycin, and cyclosporin A, the physiological role of the unligated proteins is not known. A 59-kilodalton member of the FK506- and rapamycin-binding class was found to associate in the absence of these drugs with two heat shock proteins (hsp90 and hsp70) and the glucocorticoid receptor (GR). Together, these proteins make up the inactive GR, thus biochemically linking two families of proteins proposed to be involved in protein folding and assembly as well as two potent immunosuppressive modalities.
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Cites
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
Self-citationThe mechanism of action of cyclosporin A and FK506
Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127
Self-citationChemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands
Schreiber, S. L. (1991) · Science · doi:10.1126/science.1702904 · Cited by 1,494
Self-citationA 59-kilodalton protein associated with progestin, estrogen, androgen and glucocorticoid receptors
Tai, P. K. K., Maeda, Y., Nakao, K., Wakim, N. G., Duhring, J. L., & Faber, L. E. (1986) · Biochemistry · doi:10.1021/bi00366a043 · Cited by 257
Smith, D. F., Faber, L. E., & Toft, D. O. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39693-0 · Cited by 221
HSP56: a novel heat shock protein associated with untransformed steroid receptor complexes
Sanchez, E. R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45667-0 · Cited by 214
Cited by
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791
Wochnik, G. M., Rüegg, J., Abel, G. A., Schmidt, U., Holsboer, F., & Rein, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m407498200 · Cited by 638
Dawson, T. M., Steiner, J. P., Dawson, V. L., Dinerman, J. L., Uhl, G. R., & Snyder, S. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.9808 · Cited by 538
A New First Step in Activation of Steroid Receptors
Davies, T. H., Ning, Y.-M., & Sánchez, E. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100531200 · Cited by 427
Inhibition of nuclear hormone receptor activity by calreticulin
Dedhar, S., Rennie, P. S., Shago, M., Hagesteijn, C.-Y. L., Yang, H., Filmus, J., Hawley, R. G., Bruchovsky, N., Cheng, H., Matusik, R. J., et al. (1994) · Nature · doi:10.1038/367480a0 · Cited by 375
Metadata
- Authors
- Tai, P.-K. K., Albers, M. W., Chang, H., Faber, L. E., & Schreiber, S. L.
- Venue
- Science
- Published
- 1992-05-29
- Volume
- 256
- Issue
- 5061
- Pages
- 1315-1318
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986094270
- Cited by
- 304
- References
- 6
- FWCI
- 18.07
- Type
- journal article
- Language
- en
- Open access
- closed
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