The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Overlapping but Nonidentical Binding Sites on CD2 for CD58 and a Second Ligand CD59
Abstract
The interaction of the T cell glycoprotein CD2 with one ligand, CD58, contributes to T cell function. We have identified CD59, a glycoprotein with complement-inhibitory function, as a second physiological ligand for CD2. Antibodies to CD59 inhibit CD2-dependent T cell activation in murine T cell hybridomas expressing human CD2. In an in vitro binding assay with purified CD58 and CD59, CD2 + cells bind not only immobilized CD58 but also CD59. With two complementary approaches, it was demonstrated that the binding sites on CD2 for CD58 and CD59 are overlapping but nonidentical. These observations suggest that direct interactions between CD2 and both CD58 and CD59 contribute to T cell activation and adhesion.
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Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Cited by
The structure and ligand interactions of CD2: implications for T-cell function
Davis, S. J., & van der Merwe, P. A. (1996) · Immunology Today · doi:10.1016/0167-5699(96)80617-7 · Cited by 391
Membrane proteins that protect against complement lysis
Morgan, B. P., & Meri, S. (1994) · Springer Seminars in Immunopathology · doi:10.1007/bf01837366 · Cited by 263
Metadata
- Authors
- Hahn, W. C., Menu, E., Bothwell, A. L. M., Sims, P. J., & Bierer, B. E.
- Venue
- Science
- Published
- 1992-06-26
- Volume
- 256
- Issue
- 5065
- Pages
- 1805-1807
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968736929
- Cited by
- 167
- References
- 1
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Overlapping but Nonidentical Binding Sites on CD2 for CD58 and a Second Ligand CD59. https://app.cochat.ai/papers/10.1126/science.1377404
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- Hahn, W. C., Menu, E., Bothwell, A. L. M., Sims, P. J., & Bierer, B. E. (1992). Overlapping but Nonidentical Binding Sites on CD2 for CD58 and a Second Ligand CD59. Science. https://doi.org/10.1126/science.1377404
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
