The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas
Abstract
Immature T cells and some T cell hybridomas undergo apoptotic cell death when activated through the T cell receptor complex, a phenomenon that is probably related to antigen induced negative selection of developing T cells. This activation-induced apoptosis depends on active protein and RNA synthesis in the dying cells, although none of the genes required for this process have previously been identified. Antisense oligonucleotides corresponding to c- myc block the constitutive expression of c-Myc protein in T cell hybridomas and interfere with all aspects of activation-induced apoptosis without affecting lymphokine production in these cells. These data indicate that c- myc expression is a necessary component of activation-induced apoptosis.
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Prendergast, G. C., Lawe, D., & Ziff, E. B. (1991) · Cell · doi:10.1016/0092-8674(91)90457-a · Cited by 558
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Reflecting on 25 years with MYC
Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575
Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F., et al. (1995) · Nature · doi:10.1038/373441a0 · Cited by 1,314
Self-citationGreen, D. R., & Evan, G. I. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00024-7 · Cited by 1,254
Self-citationToward an understanding of the molecular mechanisms of physiological cell death.
Vaux, D. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.786 · Cited by 608
Metadata
- Authors
- Shi, Y., Glynn, J. M., Guilbert, L. J., Cotter, T. G., Bissonnette, R. P., & Green, D. R.
- Venue
- Science
- Published
- 1992-07-10
- Volume
- 257
- Issue
- 5067
- Pages
- 212-214
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2063135487
- Cited by
- 695
- References
- 1
- FWCI
- 30.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shi, Y., Glynn, J. M., Guilbert, L. J., Cotter, T. G., Bissonnette, R. P., & Green, D. R. (1992). Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas. Science. https://doi.org/10.1126/science.1378649
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
