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Lactate Dehydrogenase Isozymes: Dissociation and Recombination of Subunits
Abstract
Lactate dehydrogenase from beef tissues may be resolved electrophoretically into five isozymes each of which is a tetramer. These tetramers can be dissociated into monomers by freezing in 1 M sodium chloride. On thawing, reassociation into functional tetramers occurs. On the basis of charge and amino acid composition there are two kinds of monomers. Lactate dehydrogenase-1 contains one kind of monomer and lactate dehydrogenase-5 the other kind. A mixture of equal quantities of these two isozymes, after dissociation and reassociation, leads to the production of all five isozymes in the expected proportions of 1:4:6:4:1.
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Cited by
Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals
Schueren, F., Lingner, T., George, R., Hofhuis, J., Dickel, C., Gärtner, J., & Thoms, S. (2014) · eLife · doi:10.7554/elife.03640 · Cited by 180
Lactate deficit in an Alzheimer disease mouse model: the relationship with neuronal damage
Zhang, M., Cheng, X., Dang, R., Zhang, W., Zhang, J., & Yao, Z. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly102 · Cited by 130
Lactate dehydrogenase. Biochemistry and function of lactate dehydrogenase
Markert, C. L. (1984) · Cell Biochemistry and Function · doi:10.1002/cbf.290020302 · Cited by 115
Self-citationMethods for the separation of lactate dehydrogenases and clinical significance of the enzyme
Kopperschläger, G., & Kirchberger, J. (1996) · Journal of Chromatography B: Biomedical Sciences and Applications · doi:10.1016/0378-4347(96)00133-8 · Cited by 91
Metadata
- Authors
- Markert, C. L.
- Venue
- Science
- Published
- 1963-06-21
- Volume
- 140
- Issue
- 3573
- Pages
- 1329-1330
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2029131085
- Cited by
- 689
- References
- 0
- FWCI
- 70.46
- Type
- journal article
- Language
- en
- Open access
- closed
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