Biological Mechanisms Underlying the Aging Process: The ideas and techniques of genetics are being used to obtain new insight into the problems of aging.

Curtis, Howard J.

doi:10.1126/science.141.3582.686

Cited by 190Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceEffects of Radiation Exposure

Biological Mechanisms Underlying the Aging Process: The ideas and techniques of genetics are being used to obtain new insight into the problems of aging.

Curtis, Howard J.·1963·Science

DOI 10.1126/science.141.3582.686

Open this paper in CoChat — free account

Abstract

Several theories put forward to explain the biological mechanisms underlying the aging process are examined. The only ones which attack the problem from the point of view of basic biological mechanisms are the wear-and- tear theory and the somatic mutation theory. The finding that radiation accelerates the aging process is a potent tool for attacking the problem experimentally. Experiments with mice specifically designed to verify the wear- and-tear theory showed conclusively that stress per se does not contribute to aging, and no experimental evidence could be found to support the theory. On the other hand, a great deal of evidence now available indicates that mutations in somatic cells play a dominant role in aging. It is further shown that the organs having cells which frequently undergo cell division take part in the aging process very little, if at all. Organs having cells which seldom, if ever, divide have no opportunity to throw off either spontaneous or induced mutations, and it is these organs which are responsible for the aging of the animal. Spontaneous mutations build up at a rapid rate in these organs. A cell may continue to function normally long after it has suffered a deleterious mutation, and thismore » accounts for much of the delay in the expression of radiation damage. It is suggested that the mutation rates for somatic celis are very much higher than the rates for gametic cells, and that this circumstance insures the death of the individual and the survival of the species. (auth)« less

Integrity signals

Registry

Crossref · 10.1126/science.141.3582.686

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A similar age-dependent increase in chromosomal instability has been known to occur in mammals for many years.
“A similar age-dependent increase in chromosomal instability has been known to occur in mammals for many years 27”
From The common biology of cancer and ageing (2007) · cites this paper as [27]

On the nature of the aging process
Szilard, L. (1959) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.45.1.30 · Cited by 651 · see citing works
The biology of senescence
Comfort, A. (1956) · Rinehart eBooks · doi:10.5962/bhl.title.6435 · Cited by 598 · see citing works
ACTION OF X-RAYS ON MAMMALIAN CELLS
Puck, T. T., Morkovin, D., Marcus, P. I., & Cieciura, S. J. (1957) · The Journal of Experimental Medicine · doi:10.1084/jem.106.4.485 · Cited by 252 · see citing works
Distribution of Human Chromosome Counts in Relation to Age
Jacobs, P. A., Brown, W. M. C., & Doll, R. (1961) · Nature · doi:10.1038/1911178a0 · Cited by 249 · see citing works
Persistent Chromosome Aberrations in Irradiated Human Subjects
Bender, M. A., & Gooch, P. C. (1962) · Radiation Research · doi:10.2307/3571128 · Cited by 215 · see citing works
A Special Consideration of the Aging Process, Disease, and Life Expectancy
Jones, H. B. (1956) · Advances in biological and medical physics · doi:10.1016/b978-1-4832-3110-5.50012-1 · Cited by 111 · see citing works
Aging: Some Social and Biological Aspects
Welford, A. T. (1961) · Journal of Gerontology · doi:10.1093/geronj/16.3.258a · Cited by 107 · see citing works
THE DEVELOPMENT OF SOMATIC MUTATIONS IN MICE WITH AGE
Crowley, C., & Curtis, H. J. (1963) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.49.5.626 · Cited by 90 · see citing works
Self-citation
Induced Mutations and Possible Mechanisms of the Transmission of Heredity in Escherichia Coli
Demerec, M. (1946) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.32.2.36 · Cited by 88 · see citing works
Ionizing Radiation and the Aging Process: A Review
Upton, A. C. (1957) · Journal of Gerontology · doi:10.1093/geronj/12.3.306 · Cited by 85 · see citing works
Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging
Curtis, H. J., & Crowley, C. (1963) · Radiation Research · doi:10.2307/3571455 · Cited by 74 · see citing works
Self-citation
Aspects of Aging in Plants
Sax, K. (1962) · Annual Review of Plant Physiology · doi:10.1146/annurev.pp.13.060162.002421 · Cited by 66 · see citing works
Chromosomal Aberrations in Irradiated and Nitrogen Mustard-Treated Mice
Stevenson, K. G., & Curtis, H. J. (1961) · Radiation Research · doi:10.2307/3571114 · Cited by 60 · see citing works
Self-citation
Shortening of the Life Span of Mice by Irradiation with X-Rays and Treatment with Radiomimetic Chemicals
Alexander, P. M., & Connell, D. I. (1960) · Radiation Research · doi:10.2307/3570821 · Cited by 39 · see citing works
AN HYPOTHESIS CONCERNING RNA METABOLISM AND AGING
Wulff, V. J., Quastler, H., & Sherman, F. G. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.8.1373 · Cited by 35 · see citing works
Correlation between Mean Litter Size and Mean Life Span among 12 Inbred Strains of Mice
Roderick, T. H., & Storer, J. B. (1961) · Science · doi:10.1126/science.134.3471.48 · Cited by 31 · see citing works
Comparative Late Somatic Effects of Some Radiomimetic Agents and X-Rays
Conklin, J. W., Upton, A. C., Christenberry, K. W., & McDonald, T. P. (1963) · Radiation Research · doi:10.2307/3571416 · Cited by 31 · see citing works
FACTORS RESPONSIBLE FOR THE DELAYED APPEARANCE OF RADIATION-INDUCED MUTANTS IN ESCHERICHIA COLI
Newcombe, H. B., & Scott, G. W. (1949) · Genetics · doi:10.1093/genetics/34.5.475 · Cited by 31 · see citing works
Age at Exposure and the Late Effects of X-Rays. Survival and Tumor Incidence in CAF 1 Mice Irradiated at 1 to 2 Years of Age
Kohn, H. I., & Guttman, P. H. (1963) · Radiation Research · doi:10.2307/3571501 · Cited by 26 · see citing works
X-Irradiation-Induced Mitotic Abnormalities in Mouse Liver Regenerating after Carbon Tetrachloride Injury. II. Partial-Body Irradiation 2 3
Albert, M. D. (1958) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/20.2.321 · Cited by 18 · see citing works
Effects of Atropine Sulfate on the Conditioned Aversion to Saccharin Fluid with X-Rays as the Unconditioned Stimulus
Smith, J. C., & Morris, D. D. (1963) · Radiation Research · doi:10.2307/3571438 · Cited by 14 · see citing works
Uber die Bestandteile der Pirolaceae-Pflanzen. VI. Uber die Bestandteile von Pirola incarnata FISCH. (1).
Inouye, H. (1956) · Pharmaceutical Bulletin · doi:10.1248/cpb1953.4.281 · Cited by 6 · see citing works

Flagged first, then by citations

1 of the 23 references couldn’t be matched to a known paper.

Sorted by citations

The common biology of cancer and ageing
Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988 · see citing works
Genome Instability and Aging
Vijg, J., & Suh, Y. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183715 · Cited by 386 · see citing works
Quantum Genetics and the Aperiodic Solid
Löwdin, P. (1966) · Advances in quantum chemistry · doi:10.1016/s0065-3276(08)60076-3 · Cited by 361 · see citing works
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine
Dollé, M. E. T., Snyder, W. K., Gossen, J. A., Lohman, P. H. M., & Vijg, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.15.8403 · Cited by 242 · see citing works
The Seed Bank as a Source of Genetic Novelty in Plants
Levin, D. A. (1990) · The American Naturalist · doi:10.1086/285062 · Cited by 170 · see citing works
Somatic Mosaicism in the Human Genome
Freed, D. N., Stevens, E. L., & Pevsner, J. (2014) · Genes · doi:10.3390/genes5041064 · Cited by 150 · see citing works
THE CROSSLINKAGE THEORY OF AGING
Bjorksten, J. (1968) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1968.tb02821.x · Cited by 149 · see citing works
Large genome rearrangements as a primary cause of aging
Vijg, J., & Dollé, M. E. T. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00028-3 · Cited by 146 · see citing works
CHROMOSOME COMPLEMENT AS A DETERMINANT OF THE MORPHOGENIC POTENTIAL OF TOBACCO CELLS
Murashige, T., & Nakano, R. (1967) · American Journal of Botany · doi:10.1002/j.1537-2197.1967.tb10721.x · Cited by 142 · see citing works
Relationship Between the Radiation Dose and Chromosome Aberrations in Atomic Bomb Survivors of Hiroshima and Nagasaki
Awa, A. A., Sofuni, T., HONDA, T., ITOH, M., Neriishi, S., & Ôtake, M. (1978) · Journal of Radiation Research · doi:10.1269/jrr.19.126 · Cited by 141 · see citing works
Somatic mutations, genome mosaicism, cancer and aging
Vijg, J. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.04.002 · Cited by 134 · see citing works
The Aging Kidney: A Review – Part I
Silva, F. G. (2005) · International Urology and Nephrology · doi:10.1007/s11255-004-0873-6 · Cited by 131 · see citing works
Loss of Genes coding for Ribosomal RNA in Ageing Brain Cells
Johnson, R. W., & Strehler, B. L. (1972) · Nature · doi:10.1038/240412a0 · Cited by 130 · see citing works
The Biology of Aging
Goldstein, S. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111112852005 · Cited by 127 · see citing works
Epidemiology, Risk Factors, Prevention, and Early Detection of Melanoma
Azoury, S. C., & Lange, J. R. (2014) · Surgical Clinics of North America · doi:10.1016/j.suc.2014.07.013 · Cited by 124 · see citing works
Theories of Aging and the Prevalence of Alzheimer’s Disease
Trevisan, K., Cristina-Pereira, R., Silva-Amaral, D., & Aversi‐Ferreira, T. A. (2019) · BioMed Research International · doi:10.1155/2019/9171424 · Cited by 111 · see citing works
Correlations between tests of aging in Hiroshima subjects--an attempt to define "physiologic age".
Hollingsworth, J. W., Hashizume, A., & Jablon, S. (1965) · PubMed Central · Cited by 112 · see citing works
Serum Anti-γ-Globulin and Antinuclear Factors in the Aged
Cammarata, R. J. (1967) · JAMA · doi:10.1001/jama.1967.03120070067008 · Cited by 106 · see citing works
Chemical Carcinogenesis
Ryser, H. J. ‐. (1971) · New England Journal of Medicine · doi:10.1056/nejm197109232851305 · Cited by 103 · see citing works
Mistranslation and Ageing in Neurospora
LEWIS, C. M., & Holliday, R. (1970) · Nature · doi:10.1038/228877a0 · Cited by 98 · see citing works
Somatic Mutation and Chronic Disease
Burnet, M. (1965) · BMJ · doi:10.1136/bmj.1.5431.338 · Cited by 94 · see citing works
Biological Mechanisms of Aging
Whipple, R. O. (1963) · Science · doi:10.1126/science.142.3597.1261 · Cited by 91 · see citing works
MORPHOGENETIC BEHAVIOR OF TOBACCO TISSUE CULTURES AND IMPLICATION OF PLANT SENESCENCE
Murashige, T., & Nakano, R. (1965) · American Journal of Botany · doi:10.1002/j.1537-2197.1965.tb07253.x · Cited by 82 · see citing works
The effect of pregnancy and of Enovid on the rabbit vasculature
Danforth, D. N., Manalo-Estrella, P., & Buckingham, J. C. (1964) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(64)90741-0 · Cited by 82 · see citing works
Repetition of molecular-genetic information as a possible factor in evolutionary changes of life span
Medvedev, Z. A. (1972) · Experimental Gerontology · doi:10.1016/0531-5565(72)90012-5 · Cited by 74 · see citing works
A Histologic Study of Age Changes in the Adult Human Periodontal Joint (Ligament)
Severson, J. A., Moffett, B. C., Kōkich, V. G., & Selipsky, H. (1978) · Journal of Periodontology · doi:10.1902/jop.1978.49.4.189 · Cited by 73 · see citing works
Age-associated structural alterations in senescent mouse brain DNA
Chetsanga, C. J., Tuttle, M., Jacoboni, A., & Johnson, C. J. (1977) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(77)90192-7 · Cited by 65 · see citing works
The price of tumour suppression?
Ferbeyre, G., & Lowe, S. W. (2002) · Nature · doi:10.1038/415026a · Cited by 62 · see citing works
Studies of the incidence and significance of anti‐gamma globulin factors in the aging
Litwin, S. D., & Singer, J. M. (1965) · Arthritis & Rheumatism · doi:10.1002/art.1780080408 · Cited by 62 · see citing works
Proton Radiation Alters Intrinsic and Synaptic Properties of CA1 Pyramidal Neurons of the Mouse Hippocampus
Sokolova, I. V., Schneider, C. J., Bezaire, M., Soltesz, I., Vlkolinsky, R., & Nelson, G. A. (2015) · Radiation Research · doi:10.1667/rr13785.1 · Cited by 62 · see citing works
Review of Genetic Investigations into the Aging Processes of Drosophila
Arking, R., & Dudas, S. P. (1989) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1989.tb02240.x · Cited by 59 · see citing works
Radiation and aging: Free radical damage, biological response and possible antioxidant intervention
Greenstock, C. L. (1993) · Medical Hypotheses · doi:10.1016/0306-9877(93)90131-9 · Cited by 56 · see citing works
Teorias biológicas do envelhecimento
Mota, M. P., Figueiredo, P., & Duarte, J. A. (2004) · Revista Portuguesa de Ciências do Desporto · doi:10.5628/rpcd.04.01.81 · Cited by 53 · see citing works
Werner’s Syndrome: A Review of its Symptomatology, Natural History, Pathologic Features, Genetics and Relationship to the Natural Aging Process
Epstein, C. J., Martin, G. M., Schultz, A. L., & Motulsky, A. G. (1985) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-7853-2_3 · Cited by 53 · see citing works
POSSIBLE SOMATIC CELL MATING IN TWIN CATTLE WITH ERYTHROCYTE MOSAICISM
Stone, W. H., Friedman, J., & Fregin, A. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.6.1036 · Cited by 53 · see citing works
Genome dynamics and transcriptional deregulation in aging
Busuttil, R. A., Bahar, R., & Vijg, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.060 · Cited by 49 · see citing works
Phenome and genome based studies into human ageing and longevity: An overview
Slagboom, P. E., van den Berg, N., & Deelen, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.017 · Cited by 49 · see citing works
Hormones as Etiological Agents in Neoplasia
Fürth, J. (1975) · Springer eBooks · doi:10.1007/978-1-4613-4449-0_4 · Cited by 47 · see citing works
Influence of Radiation Dose Rate on Somatic Mutation Induction in Tradescantia Stamen Hairs
Nauman, C. H., Underbrink, A. G., & Sparrow, A. H. (1975) · Radiation Research · doi:10.2307/3574186 · Cited by 44 · see citing works
Aging is a deprivation syndrome driven by a germ–soma conflict
Heininger, K. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00015-6 · Cited by 38 · see citing works
Chromosome Aberrations in Radiation Workers
Norman, A., Sasaki, M., Ottoman, R. E., & Veomett, R. C. (1964) · Radiation Research · doi:10.2307/3571608 · Cited by 38 · see citing works
Coexpression of C- myc and transforming growth factor alfa in the liver promotes early replicative senescence and diminishes regenerative capacity after partial hepatectomy in transgenic mice
Factor, V. M., Jensen, M. R., & Thorgeirsson, S. S. (1997) · Hepatology · doi:10.1002/hep.510260610 · Cited by 37 · see citing works
Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains
Brinkmeyer‐Langford, C., Guan, J., Ji, G., & Cai, J. J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00183 · Cited by 34 · see citing works
Further considerations towards an immunologic theory of aging
Walford, R. L. (1964) · Experimental Gerontology · doi:10.1016/0531-5565(64)90008-7 · Cited by 34 · see citing works
Physical anthropological approaches to aging
Borkan, G. A., Hults, D. E., & Mayer, P. J. (1982) · American Journal of Physical Anthropology · doi:10.1002/ajpa.1330250511 · Cited by 33 · see citing works
The Diseases Drugs Cause
Lasagna, L. C. (1964) · Perspectives in biology and medicine · doi:10.1353/pbm.1964.0015 · Cited by 33 · see citing works
Steady-state levels of 7-methylguanine increase in nuclear DNA of postmitotic mouse tissues during aging
Tan, B. H., Bencsath, F. A., & Gaubatz, J. W. (1990) · Mutation Research/DNAging · doi:10.1016/0921-8734(90)90004-b · Cited by 32 · see citing works
Biological significance of liver cell polyploidy: an hypothesis
Uryvaeva, I. V. (1981) · Journal of Theoretical Biology · doi:10.1016/0022-5193(81)90028-x · Cited by 32 · see citing works
The Elimination of Chromosome Aberrations in Liver Cells by Cell Division
Curtis, H. J., Tilley, J., & Crowley, C. (1964) · Radiation Research · doi:10.2307/3571554 · Cited by 32 · see citing works
Self-citation
THE ONSET OF RHEUMATOID ARTHRITIS IN THE AGED
Brown, J. W., & Sones, D. A. (1967) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1967.tb02518.x · Cited by 32 · see citing works
Effect of low dose rate irradiation on the division potential of cells in vitro. VI. Changes in DNA and in radiosensitivity during aging of human fibroblasts
Icard‐Liepkalns, C., Beaupain, R., Diatloff-Zito, C., & Macieira‐Coelho, A. (1979) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(79)90006-x · Cited by 31 · see citing works
Aging in vitro
Lima, L. M., Malaise, E. P., & Macieira‐Coelho, A. (1972) · Experimental Cell Research · doi:10.1016/0014-4827(72)90057-2 · Cited by 31 · see citing works
Senescence in Drosophila—II. Renewal of catalase activity in flies of different ages
Nicolosi, R. J., Baird, M. B., Massie, H. R., & Samis, H. V. (1973) · Experimental Gerontology · doi:10.1016/0531-5565(73)90020-x · Cited by 30 · see citing works
Aging Affects the Levels of DNA Damage in Postmitotic Cellsa
Gaubatz, J. W., & Tan, B. H. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb56822.x · Cited by 30 · see citing works
Ageing of Mammals
Bullough, W. S. (1971) · Nature · doi:10.1038/229608a0 · Cited by 29 · see citing works
A Model for Aging Based on Differential Repair of Somatic Mutational Damage
Yielding, K. L. (1974) · Perspectives in biology and medicine · doi:10.1353/pbm.1974.0035 · Cited by 29 · see citing works
The effect of light on the aging of human diploid fibroblasts
Litwin, J. (1972) · Experimental Gerontology · doi:10.1016/0531-5565(72)90062-9 · Cited by 29 · see citing works
An improved method of mouse liver micronucleus analysis: an application to age-related genetic alteration and polyploidy study
Uryvaeva, I. V., & Delone, G. V. (1995) · Mutation Research/Environmental Mutagenesis and Related Subjects · doi:10.1016/0165-1161(95)90032-2 · Cited by 28 · see citing works
A search for DNA alterations in the aging mammalian genome: An experimental strategy
Vijg, J., & Uitterlinden, A. G. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90053-4 · Cited by 27 · see citing works
Formal discussion of: somatic mutations and carcinogenesis.
Curtis, H. J. (1965) · PubMed · Cited by 25 · see citing works
Self-citation
Genetic Aspects of Drosophila as a Model System of Eukaryotic Aging
Mayer, P. J., & Baker, G. T. (1985) · International review of cytology · doi:10.1016/s0074-7696(08)60579-3 · Cited by 25 · see citing works
The Effect of Whole-Body X-Irradiation on the Median Lifespan of Female Dogs (Beagles)
Andersen, A. C., & Rosenblatt, L. S. (1969) · Radiation Research · doi:10.2307/3572640 · Cited by 24 · see citing works
Evidence for an increased level of DNA damage in high doubling level human diploid cells in culture
Dell’Orco, R. T., & Whittle, W. L. (1981) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(81)90070-1 · Cited by 24 · see citing works
Evolution and longevity-assurance processes
Hart, R. W., & Turturro, A. (1981) · Die Naturwissenschaften · doi:10.1007/bf00401663 · Cited by 23 · see citing works
Mutations and Aging
Kohn, R. R. (1963) · Science · doi:10.1126/science.142.3592.540 · Cited by 22 · see citing works
Neurochemistry of Aging
Samorajski, T., & Ordy, J. M. (1972) · Advances in behavioral biology · doi:10.1007/978-1-4684-8503-5_5 · Cited by 21 · see citing works
Environmental factors in aging and mortality
Strehler, B. L. (1967) · Environmental Research · doi:10.1016/0013-9351(67)90005-9 · Cited by 20 · see citing works
Über Alterungserscheinungen bei traumatisch induzierter meristematischer Aktivität
Lange, H., & Rosenstock, G. (1964) · Journal of Phytopathology · doi:10.1111/j.1439-0434.1964.tb03419.x · Cited by 19 · see citing works
Aging and DNA-Repair Capability
Tice, R. R. (1978) · Springer eBooks · doi:10.1007/978-1-4684-2445-4_4 · Cited by 18 · see citing works
Development of Language: Suggestions for a Verbal Fallout Model
Riegel, K. F. (2009) · Human Development · doi:10.1159/000270395 · Cited by 18 · see citing works
Micronuclei and Ageing in a Sample of Yugoslavian Population
Milošević-Djordjević, O., Grujičić, D., Novakovic, T. R., Arsenijević, S., & Marinkovic, D. (2002) · Russian Journal of Genetics · doi:10.1023/a:1014342312959 · Cited by 17 · see citing works
Pathobiology of air pollutants
Boren, H. G. (1967) · Environmental Research · doi:10.1016/0013-9351(67)90012-6 · Cited by 17 · see citing works
Early Programming of Adult Longevity: Demographic and Experimental Studies
Vaiserman, A. M., & Voitenko, V. P. (2003) · Rejuvenation Research · doi:10.1089/109454503765361542 · Cited by 17 · see citing works
The role of infidelity of transfer of information for the accumulation of age changes in differentiated cells
Медведев, Ж. А. (1980) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(80)90102-5 · Cited by 17 · see citing works
A comparison of DNA repair synthesis in primary hepatocytes from young and old rats
Kennah, H. E., Coetzee, M. L., & Ove, P. (1985) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(85)90068-5 · Cited by 17 · see citing works
Environmental Stress and Biological Ageing
Ordy, J. M., Rolsten, C., Samorajski, T., & COLLINS, R. L. (1964) · Nature · doi:10.1038/204724a0 · Cited by 17 · see citing works
The interpretation of microbeam experiments for manned space flight.
Curtis, H. J. (1967) · PubMed · Cited by 16 · see citing works
Self-citation
Longevity: Some familial correlates
Philippe, P. (1980) · Social Biology · doi:10.1080/19485565.1980.9988423 · Cited by 16 · see citing works
Does transcription-associated DNA damage limit lifespan?
Callegari, A. J. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.03.001 · Cited by 15 · see citing works
Age-specific nuclear proteins in the nematode worm Caenorhabditis elegans
Meheus, L., BEEUMEN, J. V., Coomans, A., & Vanfleteren, J. R. (1987) · Biochemical Journal · doi:10.1042/bj2450257 · Cited by 15 · see citing works
Hormones as Etiological Agents in Neoplasia
Fürth, J. (1982) · Springer eBooks · doi:10.1007/978-1-4615-6598-7_4 · Cited by 14 · see citing works
VARIATION OF INTESTINAL ACTIVITY WITH AGE: A REVIEW.
Spencer, R. P. (1964) · Europe PMC (PubMed Central) · Cited by 14 · see citing works
Effect of X-irradiations on the clonal life-span and fission rate in Paramecium aurelia
Fukushima, S. (1974) · Experimental Cell Research · doi:10.1016/0014-4827(74)90405-4 · Cited by 14 · see citing works
Altern des Zentralnervensystems
Arendt, A. (1972) · Handbuch der allgemeinen Pathologie · doi:10.1007/978-3-642-80637-7_10 · Cited by 14 · see citing works
THE MUTATION THEORY OF AGING
Sinex, F. M. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-591655-4.50008-9 · Cited by 14 · see citing works
Mutation Accumulation In Vivo and the Importance of Genome Stability in Aging and Cancer
Dollé, M. E. T., Giese, H., STEEG, H. V., & Vijg, J. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-48003-7_9 · Cited by 12 · see citing works
Age-related studies on the removal of 7-methylguanine from DNA of mouse kidney tissue following N-methyl-N-nitrosourea treatment
Gaubatz, J. W., & Tan, B. H. (1993) · Mutation Research/DNAging · doi:10.1016/0921-8734(93)90004-m · Cited by 13 · see citing works
Experimental Modification of the Chemistry and Biology of the Aging Process
Kormendy, C. G., & Bender, A. D. (1971) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600600202 · Cited by 13 · see citing works
Radiation paradigm and its shift.
Sugahara, T. (1994) · Journal of Radiation Research · doi:10.1269/jrr.35.48 · Cited by 12 · see citing works
CANCER RESEARCH 1964: THOUGHTS ON THE CONTRIBUTIONS OF RADIATION BIOLOGY.
Upton, A. C. (1964) · PubMed · Cited by 12 · see citing works
Urate accumulation and adult life span in two species of Habrobracon
Clark, A. M., & Smith, R. (1967) · Experimental Gerontology · doi:10.1016/0531-5565(67)90018-6 · Cited by 12 · see citing works
Genetic analyses of aging processes inDrosophila
Arking, R. (1988) · Experimental Aging Research · doi:10.1080/03610738808259737 · Cited by 11 · see citing works
Age and Sensitivity to Radiation Life Shortening
Johnson, H. A. (1964) · Radiation Research · doi:10.2307/3571677 · Cited by 11 · see citing works
The effects of ionizing radiation on the longevity of ploidy types in the wasp Mormoniella vitripennis
Clark, A. M., & Cole, K. W. (1967) · Experimental Gerontology · doi:10.1016/0531-5565(67)90007-1 · Cited by 11 · see citing works
Psychosomatically induced death: Relative to stress, hypnosis, mind control, and voodoo: Review and possible mechanisms
Morse, D. R., Martin, J. S., & Moshonov, J. (1991) · Stress Medicine · doi:10.1002/smi.2460070404 · Cited by 11 · see citing works
Chromosome Aberrations: Increased Incidence in Bone Marrow of Continuously Irradiated Rats
Chlebovský, O., Praslička, M., & Horák, J. (1966) · Science · doi:10.1126/science.153.3732.195 · Cited by 11 · see citing works
AN INTEGRATED THEORY OF AGING
Carpenter, D. G., & Loynd, J. A. (1968) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1968.tb02774.x · Cited by 11 · see citing works
Kausalanalytische Untersuchungen zum Alterungsvorgang bei der Wundkompensation von Speicherorganen unter besonderer Berücksichtigung des Nährstoffaktors
Lange, H., & Rosenstock, G. (1965) · Journal of Phytopathology · doi:10.1111/j.1439-0434.1965.tb02176.x · Cited by 11 · see citing works
TISSUE HOMEOSTASIS IN ADULT MAMMALS
Bullough, W. S., & Laurence, E. B. (1966) · Elsevier eBooks · doi:10.1016/b978-0-08-011576-4.50006-4 · Cited by 11 · see citing works
R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements
Ellis, D., Martín, F. R., Rodríguez‐López, M., Cotobal, C., Sun, X.-M., Saintain, Q., Jeffares, D. C., Marguerat, S., Tallada, V. A., & Bähler, J. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009784 · Cited by 10 · see citing works

Authors: Curtis, H. J.
Affiliations: Brookhaven National Laboratory (US)
Corresponding author: Curtis, Howard J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1963-08-23
Volume: 141
Issue: 3582
Pages: 686-694
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.141.3582.686
OpenAlex: W2088159749
Cited by: 190
References: 23
Citations by year: 2026: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 1
FWCI: 19.70
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: aging, somatic mutation theory, radiation-induced aging, spontaneous mutation, cell division, stress and aging
MeSH terms: Biological Phenomena, Genetics, Humans, Physiological Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Biological Mechanisms Underlying the Aging Process: The ideas and techniques of genetics are being used to obtain new insight into the problems of aging.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks