The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Intercellular Propagation of Calcium Waves Mediated by Inositol Trisphosphate
Abstract
Two types of calcium (Ca 2+ ) signaling-propagating intercellular Ca 2+ waves of increasing intracellular Ca 2+ concentration ([Ca 2+ ] i ) and nonpropagating oscillations in [Ca 2+ ] i -co-exist in a variety of cell types. To investigate this difference in Ca 2+ signaling, airway epithelial cells were loaded with heparin, an inositol 1,4,5-trisphosphate (IP 3 ) receptor antagonist, by pulsed, high-frequency electroporation. Heparin inhibited propagation of intercellular Ca 2+ waves but not oscillations of [Ca 2+ ] i . In heparin-free cells, Ca 2+ waves propagated through cells displaying [Ca 2+ ] i oscillations. Depletion of intracellular Ca 2+ pools with the Ca 2+ -pump inhibitor thapsigargin also inhibited the propagation of Ca 2+ waves. These studies demonstrate that the release of Ca 2+ by IP 3 is necessary for the propagation of intercellular Ca 2+ waves and suggest that IP 3 moves through gap junctions to communicate intercellular Ca 2+ waves.
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Cites
Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling
Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., & Smith, S. J. (1990) · Science · doi:10.1126/science.1967852 · Cited by 1,846
Capacitative calcium entry revisited
Putney, J. W. (1990) · Cell Calcium · doi:10.1016/0143-4160(90)90016-n · Cited by 1,487
Cited by
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice
Kuchibhotla, K. V., Lattarulo, C. R., Hyman, B. T., & Bacskai, B. J. (2009) · Science · doi:10.1126/science.1169096 · Cited by 729
Connexin channel permeability to cytoplasmic molecules
Harris, A. L. (2007) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2007.03.011 · Cited by 455
Garaschuk, O., Hanse, E., & Konnerth, A. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.219bu.x · Cited by 348
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte
Atri, A., Amundson, J., Clapham, D., & Sneyd, J. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81191-3 · Cited by 344
Metadata
- Authors
- Boitano, S., Dirksen, E. R., & Sanderson, M. J.
- Venue
- Science
- Published
- 1992-10-09
- Volume
- 258
- Issue
- 5080
- Pages
- 292-295
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2056302193
- Cited by
- 519
- References
- 2
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boitano, S., Dirksen, E. R., & Sanderson, M. J. (1992). Intercellular Propagation of Calcium Waves Mediated by Inositol Trisphosphate. Science. https://doi.org/10.1126/science.1411526
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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