Inositol trisphosphate and calcium signalling
Abstract
Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.
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PLCγ2 cleaves the membrane phospholipid PIP2 into DAG and IP3.
“Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) belongs to a group of intracellular enzymes that cleave the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (1) (Fig. 1A).”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [1]
PLCγ2 is a critical signaling molecule activated downstream from cell surface receptors containing an intracellular immunoreceptor tyrosine-based activation motif.
“Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a critical signaling molecule activated downstream from a variety of cell surface receptors that contain an intracellular immunoreceptor tyrosine-based activation motif.”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [1]
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- Authors
- Berridge, M. J.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Berridge, Michael J.
- Venue
- Nature
- Published
- 1993-01
- Volume
- 361
- Issue
- 6410
- Pages
- 315-325
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1980166477
- Cited by
- 6,545
- References
- 2
- Citations by year
- 2026: 27 · 2025: 44 · 2024: 46 · 2023: 44 · 2022: 47 · 2021: 49 · 2020: 45 · 2019: 61 · 2018: 62 · 2017: 75 · 2016: 74 · 2015: 80 · 2014: 102 · 2013: 91 · 2012: 119
- FWCI
- 13.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- inositol trisphosphate, calcium signaling, second messengers, ryanodine receptor, calcium-induced calcium release, calcium waves, calcium oscillations, intracellular calcium channels, fertilisation (biology), smooth muscle contraction, neuronal signaling
- MeSH terms
- Animals, Calcium, Cell Cycle, Cell Division, Cell Transformation, Neoplastic, Female, Fertilization, Male, Models, Biological, Neuronal Plasticity, Protein-Tyrosine Kinases, Receptors, Cholinergic, Receptors, Cell Surface, Ryanodine, Synapses, Calcium Channels, Second Messenger Systems, Signal Transduction, Inositol 1,4,5-Trisphosphate, Receptors, Cytoplasmic and Nuclear, GTP-Binding Proteins, Ryanodine Receptor Calcium Release Channel, Inositol 1,4,5-Trisphosphate Receptors
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