The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene
Open accessAbstract
Approximately half of the neurons produced during embryogenesis normally die before adulthood. Although target-derived neurotrophic factors are known to be major determinants of programmed cell death—apoptosis—the molecular mechanisms by which trophic factors interfere with cell death regulation are largely unknown. Overexpression of the bcl-2 proto-oncogene in cultured sympathetic neurons has now been shown to prevent apoptosis normally induced by deprivation of nerve growth factor. This finding, together with the previous demonstration of bcl-2 expression in the nervous system, suggests that the Bcl-2 protein may be a major mediator of the effects of neurotrophic factors on neuronal survival.
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Cites
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252
Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., & Korsmeyer, S. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3602 · Cited by 899
Cited by
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003
Sengupta Ghosh, A., Wang, B., Pozniak, C. D., Chen, M., Watts, R. J., & Lewcock, J. W. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201103153 · Cited by 220
Chao, J.-R., Wang, J.-M., Lee, S.-F., Peng, H.-W., Lin, Y.-H., Chou, C.-H., Li, J.-C., Huang, H.-M., Chou, C.-K., Kuo, M.-L., et al. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4883 · Cited by 185
Genetic Control of Programmed Cell Death During Animal Development
Conradt, B. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091533 · Cited by 173
Eilers, A., Whitfield, J., Shah, B., Spadoni, C., Desmond, H., & Ham, J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00150.x · Cited by 96
Metadata
- Authors
- Garcia, I., Martinou, I., Tsujimoto, Y., & Martinou, J.-C.
- Venue
- Science
- Published
- 1992-10-09
- Volume
- 258
- Issue
- 5080
- Pages
- 302-304
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000646975
- Cited by
- 717
- References
- 3
- FWCI
- 24.81
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
