The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Demography of Genotypes: Failure of the Limited Life-Span Paradigm in Drosophila melanogaster
Abstract
Experimental systems that are amenable to genetic manipulation can be used to address fundamental questions about genetic and nongenetic determinants of longevity. Analysis of large cohorts of ten genotypes of Drosophila melanogaster raised under conditions that favored extended survival has revealed variation between genotypes in both the slope and location of age-specific mortality curves. More detailed examination of a single genotype showed that the mortality trajectory was best fit by a two-stage Gompertz model, with no age-specific increase in mortality rates beyond 30 days after emergence. These results are contrary to the limited life-span paradigm, which postulates well-defined, genotype-specific limits on life-span and brief periods of intense and rapidly accelerating mortality rates at the oldest age.
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Cites
Aging, natural death, and the compression of morbidity
Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356
Cited by
Broken Limits to Life Expectancy
Oeppen, J., & Vaupel, J. W. (2002) · Science · doi:10.1126/science.1069675 · Cited by 2,819
Self-citationVaupel, J. W. (2010) · Nature · doi:10.1038/nature08984 · Cited by 863
Self-citationSlowing of Mortality Rates at Older Ages in Large Medfly Cohorts
Carey, J. R., Liedo, P., Orozco, D., & Vaupel, J. W. (1992) · Science · doi:10.1126/science.1411540 · Cited by 608
Self-citationThe Reliability Theory of Aging and Longevity
GAVRILOV, L. A., & GAVRILOVA, N. S. (2001) · Journal of Theoretical Biology · doi:10.1006/jtbi.2001.2430 · Cited by 384
The analysis of survival (mortality) data: Fitting Gompertz, Weibull, and logistic functions
Wilson, D. L. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90095-7 · Cited by 156
Metadata
- Authors
- Curtsinger, J. W., Fukui, H. H., Townsend, D. R., & Vaupel, J. W.
- Venue
- Science
- Published
- 1992-10-16
- Volume
- 258
- Issue
- 5081
- Pages
- 461-463
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006369305
- Cited by
- 418
- References
- 1
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Curtsinger, J. W., Fukui, H. H., Townsend, D. R., & Vaupel, J. W. (1992). Demography of Genotypes: Failure of the Limited Life-Span Paradigm in Drosophila melanogaster. Science. https://doi.org/10.1126/science.1411541
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