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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

Schellenberg, Gerard D., Bird, Thomas D., Wijsman, Ellen M., Orr, Harry T., Anderson, Leojean, Nemens, Ellen, White, June A., Bonnycastle, Lori, Weber, James L., Alonso, M. Elisa, Potter, Huntington, Heston, Leonard L., Martin, George M.·1992·Science
DOI 10.1126/science.1411576
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Abstract

Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Z max of 9.15 (θ = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (θ = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Z max = 5.94, θ = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.

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Metadata

Authors
Schellenberg, G. D., Bird, T. D., Wijsman, E. M., Orr, H. T., Anderson, L., Nemens, E., White, J. A., Bonnycastle, L., Weber, J. L., Alonso, M. E., Potter, H., Heston, L. L., & Martin, G. M.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1992-10-23
Volume
258
Issue
5082
Pages
668-671
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1411576
OpenAlex
W2033356439
Cited by
946
References
3
FWCI
60.93
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14. https://app.cochat.ai/papers/10.1126/science.1411576
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Schellenberg, G. D., Bird, T. D., Wijsman, E. M., Orr, H. T., Anderson, L., Nemens, E., White, J. A., Bonnycastle, L., Weber, J. L., Alonso, M. E., Potter, H., Heston, L. L., & Martin, G. M. (1992). Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14. Science. https://doi.org/10.1126/science.1411576

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