The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A Comprehensive Genetic Linkage Map of the Human Genome
Abstract
A genetic linkage map of the human genome was constructed that consists of 1416 loci, including 279 genes and expressed sequences. The loci are represented by 1676 polymorphic systems genotyped with the CEPH reference pedigree resource. A total of 339 microsatellite repeat markers assayed by PCR are contained within the map, and of the 351 markers with heterozygosities of at least 70%, 205 are microsatellites. Seven telomere loci define physical and genetic endpoints for 2q, 4p, 7q, 8p, 14q, 16p, and 16q, and in other cases distal markers on the maps have been localized to terminal cytogenetic bands. Therefore, at least 92% of the autosomal length of the genome and 95% of the X chromosome is estimated to be spanned by the map. Since the maps have relatively high marker density and numerous highly informative loci, they can be used to map disease phenotypes, even for those with limited pedigree resources. The baseline map provides a foundation for achieving continuity of clone-based physical maps and for the development of a truly integrated physical, genetic, and cytogenetic map of the human.
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Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
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Identification of the Cystic Fibrosis Gene: Genetic Analysis
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The neurofibromatosis type 1 gene encodes a protein related to GAP
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Cited by
Finishing the euchromatic sequence of the human genome
International Human Genome Sequencing Consortium (2004) · Nature · doi:10.1038/nature03001 · Cited by 4,971
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
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A genome-wide search for human type 1 diabetes susceptibility genes
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Metadata
- Authors
- NIH/CEPH Collaborative Mapping Group
- Venue
- Science
- Published
- 1992-10-02
- Volume
- 258
- Issue
- 5079
- Pages
- 67-86
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4211252102
- Cited by
- 358
- References
- 6
- FWCI
- 45.01
- Type
- journal article
- Language
- en
- Open access
- closed
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