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A GDP Dissociation Inhibitor That Serves as a GTPase Inhibitor for the Ras-Like Protein CDC42Hs

Hart, Matthew J., Maru, Yoshiro, Leonard, David, Witte, Owen N., Evans, Tony, Cerione, Richard A.·1992·Science
DOI 10.1126/science.1439791
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Abstract

Members of the family of Ras-related guanosine triphosphate (GTP) binding proteins appear to take part in the regulation of a number of biological processes, including cell growth and differentiation. Three different classes of proteins that regulate the GTP binding and GTP hydrolytic activities of the Ras family members have been identified. These different regulatory proteins inhibit guanosine diphosphate (GDP) dissociation (designated as GDIs), stimulate GDP dissociation and GDP-GTP exchange (designated as GDSs), or stimulate GTP hydrolysis (designated as GAPs). In the case of the Ras-like protein CDC42Hs, which is the human homolog of a Saccharomyces cerevisiae cell division cycle protein, the GDI protein also inhibited both the intrinsic and GAP-stimulated hydrolysis of GTP. These findings establish an additional role for the GDI protein—namely, as a guanosine triphosphatase (GTPase) inhibitory protein for a Ras-like GTP binding protein.

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Research works printed but not linked: 27

  1. 10.1038/353668a0 · DOI
  2. ADAMS, J.M., THE HEMATOPOIETICALLY EXPRESSED VAV PROTOONCOGENE SHARES HOMOLOGY WITH THE DBL GDP-GTP EXCHANGE FACTOR, THE BCR GENE AND A YEAST GENE (CDC24) INVOLVED IN CYTOSKELETAL ORGANIZATION, ONCOGENE 7: 611 (1992).
  3. ARAKI, S, REGULATION OF REVERSIBLE BINDING OF SMG P25A, A RAS P21-LIKE GTP-BINDING PROTEIN, TO SYNAPTIC PLASMA-MEMBRANES AND VESICLES BY ITS SPECIFIC REGULATORY PROTEIN, GDP DISSOCIATION INHIBITOR, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 13007 (1990). · DOI
  4. ARBO, A, J BIOL CHEM 266: 23577 (1991). · DOI · Paper page
  5. 10.1146/annurev.bi.56.070187.004023 · DOI · Paper page
  6. Cerione, R. A., Receptor-Effector Coupling: A Practical Approach: 69 (1990).
  7. 10.1038/351400a0 · DOI
  8. DOWNWARD, J, STIMULATION OF P21RAS UPON T-CELL ACTIVATION, NATURE 346: 719 (1990). · DOI
  9. EVA, A, ISOLATION OF A NEW HUMAN ONCOGENE FROM A DIFFUSE B-CELL LYMPHOMA, NATURE 316: 273 (1985). · DOI
  10. FUKUMOTO, Y, MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL TYPE OF REGULATORY PROTEIN (GDI) FOR THE RHO PROTEINS, RAS P21-LIKE SMALL GTP-BINDING PROTEINS, ONCOGENE 5: 1321 (1990).
  11. GARRETT, M.D., IDENTIFICATION OF DISTINCT CYTOPLASMIC TARGETS FOR RAS R-RAS AND RHO-REGULATORY PROTEINS, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 10 (1989). · DOI
  12. HALL, A, SIGNAL TRANSDUCTION THROUGH SMALL GTPASES - A TALE OF 2 GAPS, CELL 69: 389 (1992). · DOI
  13. HALL, C, NOVEL HUMAN-BRAIN CDNA-ENCODING A 34,000 MR PROTEIN N-CHIMAERIN, RELATED TO BOTH THE REGULATORY DOMAIN OF PROTEIN KINASE-C AND BCR, THE PRODUCT OF THE BREAKPOINT CLUSTER REGION GENE, JOURNAL OF MOLECULAR BIOLOGY 211: 11 (1990). · DOI
  14. HART, M.J., IDENTIFICATION OF THE HUMAN PLATELET GTPASE ACTIVATING PROTEIN FOR THE CDC42HS PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 266: 20840 (1991). · DOI
  15. HART, M.J., CATALYSIS OF GUANINE-NUCLEOTIDE EXCHANGE ON THE CDC42HS PROTEIN BY THE DBL ONCOGENE PRODUCT, NATURE 354: 311 (1991). · DOI
  16. HEISTERKAMP, N, STRUCTURAL ORGANIZATION OF THE BCR GENE AND ITS ROLE IN THE PH' TRANSLOCATION, NATURE 315: 758 (1985). · DOI
  17. HIRAOKA, K, BOTH STIMULATORY AND INHIBITORY GDP/GTP EXCHANGE PROTEINS, SMG GDS AND RHO GDI, ARE ACTIVE ON MULTIPLE SMALL GTP-BINDING PROTEINS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 182: 921 (1992). · DOI
  18. KATZAV, S, VAV, A NOVEL HUMAN ONCOGENE DERIVED FROM A LOCUS UBIQUITOUSLY EXPRESSED IN HEMATOPOIETIC-CELLS, EMBO JOURNAL 8: 2283 (1989). · DOI · Paper page
  19. 10.1126/science.1660188 · DOI · Paper page
  20. Leonard, D., Journal of Biological Chemistry 267: 22860 (1992). · DOI · Paper page
  21. 10.1016/0092-8674(91)90148-R · DOI
  22. 10.1016/0092-8674(92)90163-7 · DOI
  23. 10.1016/0092-8674(92)90164-8 · DOI
  24. RON, D, A REGION OF PROTO-DBL ESSENTIAL FOR ITS TRANSFORMING ACTIVITY SHOWS SEQUENCE SIMILARITY TO A YEAST-CELL CYCLE GENE, CDC24, AND THE HUMAN BREAKPOINT CLUSTER GENE, BCR, NEW BIOLOGIST 3: 372 (1991).
  25. SETTLEMAN, J, MOLECULAR-CLONING OF CDNAS ENCODING THE GAP-ASSOCIATED PROTEIN P190 - IMPLICATIONS FOR A SIGNALING PATHWAY FROM RAS TO THE NUCLEUS, CELL 69: 539 (1992). · DOI
  26. 10.1126/science.2237442 · DOI
  27. UEDA, T, PURIFICATION AND CHARACTERIZATION FROM BOVINE BRAIN CYTOSOL OF A NOVEL REGULATORY PROTEIN INHIBITING THE DISSOCIATION OF GDP FROM AND THE SUBSEQUENT BINDING OF GTP TO RHOB P20, A RAS P21-LIKE GTP-BINDING PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 9373 (1990). · DOI · Paper page

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Metadata

Authors
Hart, M. J., Maru, Y., Leonard, D., Witte, O. N., Evans, T., & Cerione, R. A.
Affiliations
  • Department of Biochemistry, Cell, and Molecular Biology, Cornell University, Ithaca, NY 14853.
  • Department of Microbiology and Molecular Genetics and Molecular Biology Institute, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90024.
  • Department of Cell Biology, Genentech Inc., 460 Point San Bruno Boulevard, South San Francisco, CA 94080.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1992-10-30
Volume
258
Issue
5083
Pages
812-815
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1439791
Cited by
130
References
0
Language
en

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CoChat. (2026). Citation check: A GDP Dissociation Inhibitor That Serves as a GTPase Inhibitor for the Ras-Like Protein CDC42Hs. https://app.cochat.ai/papers/10.1126/science.1439791
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Hart, M. J., Maru, Y., Leonard, D., Witte, O. N., Evans, T., & Cerione, R. A. (1992). A GDP Dissociation Inhibitor That Serves as a GTPase Inhibitor for the Ras-Like Protein CDC42Hs. Science. https://doi.org/10.1126/science.1439791