Cell Wall Integrity Signaling in Saccharomyces cerevisiae
Open accessAbstract
SUMMARY: The yeast cell wall is a highly dynamic structure that is responsible for protecting the cell from rapid changes in external osmotic potential. The wall is also critical for cell expansion during growth and morphogenesis. This review discusses recent advances in understanding the various signal transduction pathways that allow cells to monitor the state of the cell wall and respond to environmental challenges to this structure. The cell wall integrity signaling pathway controlled by the small G-protein Rho1 is principally responsible for orchestrating changes to the cell wall periodically through the cell cycle and in response to various forms of cell wall stress. This signaling pathway acts through direct control of wall biosynthetic enzymes, transcriptional regulation of cell wall-related genes, and polarization of the actin cytoskeleton. However, additional signaling pathways interface both with the cell wall integrity signaling pathway and with the actin cytoskeleton to coordinate polarized secretion with cell wall expansion. These include Ca 2+ signaling, phosphatidylinositide signaling at the plasma membrane, sphingoid base signaling through the Pkh1 and -2 protein kinases, Tor kinase signaling, and pathways controlled by the Rho3, Rho4, and Cdc42 G-proteins.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In S. cerevisiae, Rlm1 is the major regulator of cell wall integrity and its transcriptional output includes genes involved in cell wall biogenesis, while SBF is a cell cycle transcription factor that regulates transcription of cell wall-related genes including FKS2 under conditions of cell wall stress.
“In S. cerevisiae, Rlm1 is the major regulator of cell wall integrity and its transcriptional output includes genes involved in cell wall biogenesis, while SBF is a cell cycle transcription factor that regulates the transcription of cell wall-related genes including FKS2 under conditions of cell wall stress84.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [84]
The cell wall integrity pathway is of particular importance upon echinocandin exposure and regulates glucan synthesis through Rho1 and cell wall repair.
“Of particular importance upon echinocandin exposure is the cell wall integrity (CWI) pathway, which regulates glucan synthesis through Rho1 and cell wall repair (Levin, 2005).”
From Genetic Drivers of Multidrug Resistance in Candida glabrata (2016) · cites this paper as Levin, 2005
Cites
Spellman, P. T., Sherlock, G. J., Zhang, M. Q., Iyer, V. R., Anders, K. R., Eisen, M. B., Brown, P. O., Botstein, D., & Futcher, B. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.12.3273 · Cited by 4,724 · see citing works
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., Lockshon, D., Narayan, V., Srinivasan, M., Pochart, P., et al. (2000) · Nature · doi:10.1038/35001009 · Cited by 4,706 · see citing works
Global analysis of protein localization in budding yeast
Huh, W.-K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., & O'Shea, E. K. (2003) · Nature · doi:10.1038/nature02026 · Cited by 4,248 · cited 3× · see citing works
“An interesting distinction between Mid2 and Wsc1 is the former’s uniform distribution around the cell periphery (156, 267, 129).”
BackgroundA comprehensive two-hybrid analysis to explore the yeast protein interactome
Ito, T., Chiba, T., Ozawa, R., Yoshida, M., Hattori, M., & Sakaki, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061034498 · Cited by 3,566 · see citing works
TOR, a central controller of cell growth.
Schmelzle, T., & Hall, M. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 2,044 · see citing works
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
Heitman, J., Movva, N. R., & Hall, M. N. (1991) · Science · doi:10.1126/science.1715094 · Cited by 2,010 · see citing works
Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886 · see citing works
Osmotic Stress Signaling and Osmoadaptation in Yeasts
Hohmann, S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.300-372.2002 · Cited by 1,773 · see citing works
Protein Kinase C: Structure, Function, and Regulation
Newton, A. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28495 · Cited by 1,662 · see citing works
The extended protein kinase C superfamily
MELLOR, H., & Parker, P. J. (1998) · Biochemical Journal · doi:10.1042/bj3320281 · Cited by 1,539 · see citing works
Calcineurin: Form and Function
Rusnak, F. M., & Mertz, P. S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1483 · Cited by 1,375 · see citing works
The molecular biology of the yeast saccharomyces
Gichner, T. (1982) · Biologia Plantarum · doi:10.1007/bf02909099 · Cited by 1,195 · see citing works
Ultrasensitivity in the mitogen-activated protein kinase cascade.
Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186 · see citing works
A two-component system that regulates an osmosensing MAP kinase cascade in yeast
Maeda, T., Wurgler‐Murphy, S. M., & Saito, H. (1994) · Nature · doi:10.1038/369242a0 · Cited by 1,084 · see citing works
Drubin, D. G., & Nelson, W. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81278-7 · Cited by 1,030 · see citing works
MAP Kinase Pathways in the YeastSaccharomyces cerevisiae
Gustin, M., Albertyn, J., Alexander, M., & Davenport, K. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1264-1300.1998 · Cited by 1,010 · see citing works
MAP kinase pathways in yeast: For mating and more
Herskowitz, I. (1995) · Cell · doi:10.1016/0092-8674(95)90402-6 · Cited by 1,007 · see citing works
Dynamics of cell wall structure in Saccharomyces cerevisiae
Klis, F. M., Mol, P. C., Hellingwerf, K. J., & Brul, S. (2002) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2002.tb00613.x · Cited by 1,007 · see citing works
Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction
Mochly‐Rosen, D. (1995) · Science · doi:10.1126/science.7716516 · Cited by 905 · see citing works
Posas, F., Wurgler‐Murphy, S. M., Maeda, T., Witten, E. A., Thai, T. C., & Saito, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80162-2 · Cited by 881 · see citing works
Roberts, C. J., Nelson, B., Marton, M. J., Stoughton, R. B., Meyer, M. R., Bennett, H. A., He, Y. D., Dai, H. A., Walker, W. L., Hughes, T. R., et al. (2000) · Science · doi:10.1126/science.287.5454.873 · Cited by 855 · see citing works
Kunz, J., Henríquez, R., Schneider, U., Deuter‐Reinhard, M., Movva, N. R., & Hall, M. N. (1993) · Cell · doi:10.1016/0092-8674(93)90144-f · Cited by 838 · see citing works
Bidirectional signaling between the cytoskeleton and integrins
Schoenwaelder, S. M., & Burridge, K. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80037-4 · Cited by 762 · see citing works
Role of Formins in Actin Assembly: Nucleation and Barbed-End Association
Pruyne, D., Evangelista, M., Yang, C., Bi, E., Zigmond, S. H., Bretscher, A. P., & Boone, C. M. (2002) · Science · doi:10.1126/science.1072309 · Cited by 757 · see citing works
Albertyn, J., Hohmann, S., Thevelein, J. M., & Prior, B. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.4135-4144.1994 · Cited by 731 · see citing works
TOR controls translation initiation and early G1 progression in yeast.
Barbet, N., Schneider, U., Helliwell, S. B., Stansfield, I., Tuite, M. F., & Hall, M. N. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.1.25 · Cited by 715 · see citing works
Multiple Effects of Trehalose on Protein Folding In Vitro and In Vivo
Singer, M. A., & Lindquist, S. L. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80064-7 · Cited by 698 · see citing works
Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis
Evangelista, M., Blundell, K., Longtine, M. S., Chow, C. J., Adames, N. R., Pringle, J. R., Peter, M., & Boone, C. M. (1997) · Science · doi:10.1126/science.276.5309.118 · Cited by 647 · see citing works
Architecture of the Yeast Cell Wall
KOLLÁR, R., Reinhold, B. B., Petráková, E., Yeh, H. J. C., Ashwell, G., Drgonová, J., Kapteyn, J. C., Klis, F. M., & Cabib, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17762 · Cited by 643 · see citing works
Ferrell, J. E. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20026-x · Cited by 591 · see citing works
Bakers' Yeast, a Model for Fungal Biofilm Formation
Reynolds, T. B., & Fink, G. R. (2001) · Science · doi:10.1126/science.291.5505.878 · Cited by 585 · see citing works
mDia mediates Rho-regulated formation and orientation of stable microtubules
Palazzo, A. F., Cook, T. A., Alberts, A. S., & Gundersen, G. G. (2001) · Nature Cell Biology · doi:10.1038/35087035 · Cited by 582 · see citing works
Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast
Bagnat, M., Keränen, S., Shevchenko, A., Shevchenko, A., & Simons, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3254 · Cited by 573 · see citing works
Yap1 and Skn7 Control Two Specialized Oxidative Stress Response Regulons in Yeast
Lee, J., Godon, C., Lagniel, G., Spector, D., Garin, J., Labarre, J., & Tolédano, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16040 · Cited by 567 · see citing works
Review: Cell wall assembly in yeast
Klis, F. M. (1994) · Yeast · doi:10.1002/yea.320100702 · Cited by 552 · see citing works
Johnson, D. I., & Pringle, J. R. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.1.143 · Cited by 543 · see citing works
Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity
Johnson, D. I. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.1.54-105.1999 · Cited by 534 · see citing works
Latrunculin alters the actin-monomer subunit interface to prevent polymerization
Morton, W. M., Ayscough, K. R., & McLaughlin, P. J. (2000) · Nature Cell Biology · doi:10.1038/35014075 · Cited by 523 · see citing works
Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site
Toker, A., & Newton, A. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8271 · Cited by 522 · see citing works
Antifungal agents: chemotherapeutic targets and immunologic strategies
Georgopapadakou, N. H., & Walsh, T. J. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.2.279 · Cited by 495 · see citing works
An actin nucleation mechanism mediated by Bni1 and Profilin
Sagot, I., Rodal, A. A., Moseley, J. B., Goode, B. L., & Pellman, D. S. (2002) · Nature Cell Biology · doi:10.1038/ncb834 · Cited by 493 · see citing works
Kamada, Y., Jung, U. S., Piotrowski, J., & Levin, D. E. (1995) · Genes & Development · doi:10.1101/gad.9.13.1559 · Cited by 488 · see citing works
Self-citationThermotolerance in Saccharomyces cerevisiae: the Yin and Yang of trehalose
Singer, M. A., & Lindquist, S. L. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(98)01251-7 · Cited by 482 · see citing works
Lum, P. Y., Armour, C. D., Stepaniants, S. B., Cavet, G., Wolf, M. K., Butler, J. S., Hinshaw, J. C., Garnier, P., Prestwich, G. D., Leonardson, A. S., et al. (2004) · Cell · doi:10.1016/s0092-8674(03)01035-3 · Cited by 481 · see citing works
Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae
Cid, V. J., Durán, A., del Rey, F., Snyder, M. P., Nombela, C., & Sánchez, M. (1995) · Microbiological Reviews · doi:10.1128/mr.59.3.345-386.1995 · Cited by 464 · see citing works
Identification of Yeast Rho1p GTPase as a Regulatory Subunit of 1,3-β-Glucan Synthase
Qadota, H., Python, C. P., Inoue, S., Arisawa, M., Anraku, Y., Zheng, Y., Watanabe, T., Levin, D. E., & Ohya, Y. (1996) · Science · doi:10.1126/science.272.5259.279 · Cited by 445 · see citing works
Self-citationStathopoulos, A. M., & Cyert, M. S. (1997) · Genes & Development · doi:10.1101/gad.11.24.3432 · Cited by 442 · see citing works
A Yeast Protein Similar to Bacterial Two-Component Regulators
Ota, I. M., & Varshavsky, A. J. (1993) · Science · doi:10.1126/science.8211183 · Cited by 428 · see citing works
CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast
Costanzo, M., Nishikawa, J. L., Tang, X., Millman, J. S., Schub, O., Breitkreuz, K. E., Dewar, D., Rupeš, I., Andrews, B., & Tyers, M. (2004) · Cell · doi:10.1016/j.cell.2004.05.024 · Cited by 428 · see citing works
Luyten, K., Albertyn, J., Skibbe, W. F., et al. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07122.x · Cited by 426 · see citing works
Differential Expression and Function of Two Homologous Subunits of Yeast 1,3-β-D-Glucan Synthase
Mazur, P., Morin, N. R., Baginsky, W. F., El-Sherbeini, M., Clemas, J. A., NIELSEN, J. B. K., & Foor, F. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5671 · Cited by 425 · see citing works
Jung, U. S., & Levin, D. E. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01667.x · Cited by 424 · see citing works
Self-citationA candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle
Levin, D. E., Fields, F. O., Kunisawa, R., Bishop, J. M., & Thorner, J. W. (1990) · Cell · doi:10.1016/0092-8674(90)90360-q · Cited by 413 · see citing works
Self-citationYeast formins regulate cell polarity by controlling the assembly of actin cables
Sagot, I., Klee, S. K., & Pellman, D. S. (2001) · Nature Cell Biology · doi:10.1038/ncb719 · Cited by 405 · see citing works
Yoshimoto, H., Saltsman, K., Gasch, A. P., Li, H. X., Ogawa, N., Botstein, D., Brown, P. O., & Cyert, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202718200 · Cited by 404 · see citing works
Douglas, C. M., Foor, F., Marrinan, J. A., Morin, N., Nielsen, J. B., Dahl, A. M., Mazur, P., Baginsky, W., Li, W., & el-Sherbeini, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12907 · Cited by 401 · see citing works
Tamás, M. J., Luyten, K., Sutherland, F. C. W., Hernández, A., Albertyn, J., Valadi, H., Li, H., Prior, B. A., Kilian, S. G., Ramos, J., et al. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01248.x · Cited by 396 · see citing works
Helliwell, S. B., Wagner, P., Kunz, J., Deuter‐Reinhard, M., Henríquez, R., & Hall, M. N. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.1.105 · Cited by 390 · see citing works
The role of trehalose synthesis for the acquisition of thermotolerance in yeast
Hottiger, T., VIRGILIO, C. D., Hall, M. N., et al. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb19929.x · Cited by 388 · see citing works
Cln3 Activates G1-Specific Transcription via Phosphorylation of the SBF Bound Repressor Whi5
de Bruin, R. A. M., McDonald, W. H., Kalashnikova, T. I., et al. (2004) · Cell · doi:10.1016/j.cell.2004.05.025 · Cited by 387 · see citing works
Sec3p Is a Spatial Landmark for Polarized Secretion in Budding Yeast
Finger, F. P., Hughes, T. E., & Novick, P. (1998) · Cell · doi:10.1016/s0092-8674(00)80948-4 · Cited by 384 · see citing works
FK506 and cyclosporin, molecular probes for studying intracellular signal transduction
Liu, J. O. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90048-p · Cited by 383 · see citing works
A Yeast Mitogen-Activated Protein Kinase Homolog (Mpk1p) Mediates Signalling by Protein Kinase C
Lee, K. S., Irie, K., Gotoh, Y., Watanabe, Y., Araki, H., Nishida, E., Matsumoto, K., & Levin, D. E. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.3067 · Cited by 377 · see citing works
Self-citationPROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS
Schafer, W. R., & Rine, J. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.001233 · Cited by 377 · see citing works
Audhya, A., Foti, M., & Emr, S. D. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.8.2673 · Cited by 376 · see citing works
Verna, J., Lodder, A., Lee, K., Vagts, A. J., & Ballester, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13804 · Cited by 366 · see citing works
Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect.
Levin, D. E., & Bartlett-Heubusch, E. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.5.1221 · Cited by 363 · see citing works
Self-citationThe protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.
Mendoza, I., Rubio, F., Rodriguez-Navarro, A., & Pardo, J. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37038-2 · Cited by 350 · see citing works
The Yeast Cell Wall and Septum as Paradigms of Cell Growth and Morphogenesis
Cabib, E., Roh, D.-H., Schmidt, M., Crotti, L. B., & Varma, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r000031200 · Cited by 344 · see citing works
Martı́n, H., Rodrı́guez-Pachón, J. M., Ruiz, C., Nombela, C., & Molina, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1511 · Cited by 343 · see citing works
Nonaka, H., Tanaka, K., Hirano, H., Fujiwara, T., Kohno, H., Umikawa, M., Mino, A., & Takai, Y. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00281.x · Cited by 341 · see citing works
García, R., Bermejo, C., Grau, C., Pérez, R., Rodríguez-Peña, J. M., Francois, J., Nombela, C., & Arroyo, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312954200 · Cited by 338 · see citing works
Genome-Wide Analysis of Membrane Targeting by S. cerevisiae Pleckstrin Homology Domains
Yu, J. W., Mendrola, J. M., Audhya, A., Singh, S. M., Keleti, D., DeWald, D. B., Murray, D., Emr, S. D., & Lemmon, M. A. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00083-8 · Cited by 338 · see citing works
Rho1p, a Yeast Protein at the Interface Between Cell Polarization and Morphogenesis
Drgonová, J., Drgon, T., Tanaka, K., KOLLÁR, R., Chen, G.-C., Ford, R. A., Chan, C. S. M., Takai, Y., & Cabib, E. (1996) · Science · doi:10.1126/science.272.5259.277 · Cited by 336 · see citing works
Alberts, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006205200 · Cited by 335 · see citing works
Matheos, D. P., Kingsbury, T. J., Ahsan, U. S., & Cunningham, K. W. (1997) · Genes & Development · doi:10.1101/gad.11.24.3445 · Cited by 332 · see citing works
Spatial regulation of the exocyst complex by Rho1 GTPase
Guo, W., Tamanoi, F., & Novick, P. (2001) · Nature Cell Biology · doi:10.1038/35070029 · Cited by 327 · see citing works
Zlotnik, H., Fernandez, M. P., Bowers, B., & Cabib, E. (1984) · Journal of Bacteriology · doi:10.1128/jb.159.3.1018-1026.1984 · Cited by 326 · see citing works
P., L. H., Tettelin, H., Vossen, J. H., Ram, A. F. J., ENDE, H. V. D., & Klis, F. M. (1997) · Yeast · doi:10.1002/(sici)1097-0061(199712)13:15 · Cited by 324 · see citing works
Heinisch, J. J., Lorberg, A., Schmitz, H., & Jacoby, J. J. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01375.x · Cited by 322 · see citing works
Wigge, P. A., Jensen, O. N., Holmes, S., Souès, S., Mann, M., & Kilmartin, J. V. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.967 · Cited by 316 · see citing works
Irie, K., Takase, M., Lee, K. S., Levin, D. E., Araki, H., Matsumoto, K., & Oshima, Y. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.3076-3083.1993 · Cited by 316 · see citing works
Self-citationLee, K. S., & Levin, D. E. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.172-182.1992 · Cited by 315 · see citing works
Self-citationThe yeast phosphatidylinositol-4-OH kinase Pik1 regulates secretion at the Golgi
Walch-Solimena, C., & Novick, P. (1999) · Nature Cell Biology · doi:10.1038/70319 · Cited by 314 · see citing works
Imamura, H., Tanaka, K., Hihara, T., Umikawa, M., Kamei, T., Takahashi, K., Sasaki, T., & Takai, Y. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2745 · Cited by 310 · see citing works
Cafferkey, R., Young, P. R., McLaughlin, M. M., Bergsma, D. J., Koltin, Y., Sathe, G. M., Faucette, L. F., Eng, W.-K., Johnson, R. K., & Livi, G. P. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6012-6023.1993 · Cited by 309 · see citing works
Cdc42 Interacts with the Exocyst and Regulates Polarized Secretion
Zhang, X., Bi, E., Novick, P., Du, L., Kozminski, K. G., Lipschutz, J. H., & Guo, W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107464200 · Cited by 307 · see citing works
Uncommon opportunistic fungi: new nosocomial threats
Groll, A. H., & Walsh, T. J. (2001) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2001.tb00005.x · Cited by 304 · see citing works
Philip, B., & Levin, D. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.271-280.2001 · Cited by 304 · see citing works
Self-citationBipartite Ca2+-Binding Motif in C2 Domains of Synaptotagmin and Protein Kinase C
Shao, X., Davletov, B., Sutton, R. B., Südhof, T., & Rizo, J. (1996) · Science · doi:10.1126/science.273.5272.248 · Cited by 303 · see citing works
Ogas, J., Andrews, B., & Herskowitz, I. (1991) · Cell · doi:10.1016/0092-8674(91)90445-5 · Cited by 302 · see citing works
Schmidt, A., Bickle, M., Beck, T. W., & Hall, M. N. (1997) · Cell · doi:10.1016/s0092-8674(00)81893-0 · Cited by 300 · see citing works
Cell Wall Stress Depolarizes Cell Growth via Hyperactivation of Rho1
Delley, P.-A., & Hall, M. N. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.163 · Cited by 300 · see citing works
Calcineurin: From structure to function
Aramburu, J. F., Rao, A., & Klee, C. B. (2001) · Current topics in cellular regulation · doi:10.1016/s0070-2137(01)80011-x · Cited by 298 · see citing works
The ultrastructure of yeast: Cell wall structure and formation
Osumi, M. (1998) · Micron · doi:10.1016/s0968-4328(97)00072-3 · Cited by 295 · see citing works
Strahl‐Bolsinger, S., Gentzsch, M., & Tanner, W. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00131-7 · Cited by 293 · see citing works
Morgan, B. A., Banks, G. R., Toone, W. M., Raitt, D., Kuge, S., & Johnston, L. H. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.1035 · Cited by 291 · see citing works
Formins: signaling effectors for assembly and polarization of actin filaments
Evangelista, M., Zigmond, S. H., & Boone, C. M. (2003) · Journal of Cell Science · doi:10.1242/jcs.00611 · Cited by 289 · see citing works
Kohno, H., Tanaka, K., Mino, A., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00994.x · Cited by 282 · see citing works
A Second Osmosensing Signal Transduction Pathway in Yeast
Davenport, K., Sohaskey, M. L., Kamada, Y., Levin, D. E., & Gustin, M. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.30157 · Cited by 280 · see citing works
Self-citationActivation of Yeast Protein Kinase C by Rho1 GTPase
Kamada, Y., Qadota, H., Python, C. P., Anraku, Y., Ohya, Y., & Levin, D. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9193 · Cited by 280 · see citing works
Self-citationAudhya, A., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00168-5 · Cited by 277 · see citing works
Pheromone response, mating and cell biology
Elion, E. A. (2000) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00143-0 · Cited by 276 · see citing works
Hicke, L., Zanolari, B., & Riezman, H. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.349 · Cited by 276 · see citing works
Nakamura, T., Liu, Y., Hirata, D., Namba, H., Harada, S., Hirokawa, T., & Miyakawa, T. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06090.x · Cited by 270 · see citing works
de Nobel, H., Ruiz, C., Martı́n, H., Morris, W. L., Brul, S., Molina, M., & Klis, F. M. (2000) · Microbiology · doi:10.1099/00221287-146-9-2121 · Cited by 269 · see citing works
CELL POLARITY AND MORPHOGENESIS IN BUDDING YEAST
Madden, K. T., & Snyder, M. P. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.687 · Cited by 266 · see citing works
Igual, J. C., Johnson, A. L., & Johnston, L. H. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00880.x · Cited by 264 · see citing works
Ketela, T., Green, R., & Bussey, H. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.11.3330-3340.1999 · Cited by 263 · see citing works
TOR2 is required for organization of the actin cytoskeleton in yeast
Schmidt, A., Kunz, J., & Hall, M. N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13780 · Cited by 263 · see citing works
A cell cycle checkpoint monitors cell morphogenesis in budding yeast.
Lew, D. J., & Reed, S. I. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.3.739 · Cited by 263 · see citing works
Foti, M., Audhya, A., & Emr, S. D. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2396 · Cited by 260 · see citing works
Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.
Madaule, P., Axel, R., & Myers, A. M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.3.779 · Cited by 258 · see citing works
Reinke, A. W., Anderson, S., McCaffery, J. M., Yates, J. R., Aronova, S., Chu, S., Fairclough, S. R., Iverson, C., Wedaman, K. P., & Powers, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313062200 · Cited by 257 · see citing works
Essential role of calcineurin in response to endoplasmic reticulum stress
Bonilla, M., Nastase, K. K., & Cunningham, K. W. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2343 · Cited by 255 · see citing works
Sheu, Y.-J., Santos, B., Fortin, N. Y., Costigan, C., & Snyder, M. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4053 · Cited by 255 · see citing works
Genome-wide Analysis of the Response to Cell Wall Mutations in the Yeast Saccharomyces cerevisiae
Lagorce, A., Hauser, N. C., Labourdette, D., Rodriguez, C., Martin-Yken, H., Arroyo, J., Hoheisel, J. D., & François, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211604200 · Cited by 254 · see citing works
The PMT gene family: protein O‐glycosylation in Saccharomyces cerevisiae is vital.
Gentzsch, M., & Tanner, W. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00961.x · Cited by 250 · see citing works
SBF Cell Cycle Regulator as a Target of the Yeast PKC-MAP Kinase Pathway
Madden, K. T., Sheu, Y.-J., Baetz, K., Andrews, B., & Snyder, M. P. (1997) · Science · doi:10.1126/science.275.5307.1781 · Cited by 250 · see citing works
Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast
Casamayor, A., Torrance, P. D., Kobayashi, T., Thorner, J. W., & Alessi, D. R. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80088-8 · Cited by 248 · see citing works
The glucanase‐soluble mannoproteins limit cell wall porosity in Saccharomyces cerevisiae
Nobel, J. G. D., Klis, F. M., Priem, J., Munnik, T., & ENDE, H. V. D. (1990) · Yeast · doi:10.1002/yea.320060606 · Cited by 248 · see citing works
Yeast Bim1p Promotes the G1-specific Dynamics of Microtubules
Tirnauer, J. S., O'Toole, E. T., Berrueta, L., Bierer, B. E., & Pellman, D. S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.5.993 · Cited by 245 · see citing works
Yamochi, W., Tanaka, K., Nonaka, H., Maeda, A., Musha, T., & Takai, Y. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.5.1077 · Cited by 242 · see citing works
Moriya, H., & Johnston, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305901101 · Cited by 242 · see citing works
The proliferation of MAP kinase signaling pathways in yeast
Levin, D. E., & Errede, B. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80028-x · Cited by 242 · see citing works
Self-citationStathopoulos-Gerontides, A., Guo, J. J., & Cyert, M. S. (1999) · Genes & Development · doi:10.1101/gad.13.7.798 · Cited by 240 · see citing works
MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae.
Doi, K., Gartner, A., Ammerer, G., et al. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06235.x · Cited by 239 · see citing works
The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast.
Zarzov, P., Mazzoni, C., & Mann, C. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00336.x · Cited by 238 · see citing works
Regulation of the yeast Rlm1 transcription factor by the Mpk1 cell wall integrity MAP kinase
Jung, U. S., Sobering, A. K., Romeo, M. J., & Levin, D. E. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03198.x · Cited by 237 · see citing works
Self-citationCyert, M., & Thorner, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3460 · Cited by 236 · see citing works
Dallies, N., François, J., & Paquet, V. (1998) · Yeast · doi:10.1002/(sici)1097-0061(1998100)14:14 · Cited by 236 · see citing works
Yeast osmosensor Sln1 and plant cytokinin receptor Cre1 respond to changes in turgor pressure
Reiser, V., Raitt, D. C., & Saito, H. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301099 · Cited by 234 · see citing works
Costigan, C., Gehrung, S., & Snyder, M. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.1162 · Cited by 229 · see citing works
Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm
Trainor, P. A., & Krumlauf, R. K. (2000) · Nature Cell Biology · doi:10.1038/35000051 · Cited by 229 · see citing works
Smits, G. J., Kapteyn, J. C., ENDE, H. V. D., & Klis, F. M. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80061-7 · Cited by 227 · see citing works
Kelleher, D. J., Karaoglu, D., Mandon, E. C., & Gilmore, R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00243-0 · Cited by 226 · see citing works
Popolo, L., Gilardelli, D., Bonfante, P., & Vai, M. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.2.463-469.1997 · Cited by 226 · see citing works
Desrivières, S., Cooke, F., Parker, P., & Hall, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15787 · Cited by 224 · see citing works
Gray, J. V., Ogas, J. P., Kamada, Y., Stone, M., Levin, D. E., & Herskowitz, I. (1997) · The EMBO Journal · doi:10.1093/emboj/16.16.4924 · Cited by 224 · see citing works
Self-citationThe osmotic integrity of the yeast cell requires a functional PKC1 gene product.
Paravicini, G., Cooper, M., Friedli, L., Smith, D. J., Carpentier, J. L., Klig, L. S., & Payton, M. A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.4896 · Cited by 222 · see citing works
Iida, H., Nakamura, H., Ono, T., Okumura, M. S., & Anraku, Y. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8259 · Cited by 218 · see citing works
Small, J. V. (1988) · Electron Microscopy Reviews · doi:10.1016/s0892-0354(98)90010-7 · Cited by 216 · see citing works
Molecular Identification of a Eukaryotic, Stretch-Activated Nonselective Cation Channel
Kanzaki, M., Nagasawa, M., Kojima, I., Sato, C., Naruse, K., Sokabe, M., & Iida, H. (1999) · Science · doi:10.1126/science.285.5429.882 · Cited by 213 · cited 1× · see citing works
“Mid1 does not appear to have a mammalian homolog but displays stretch-activated Ca(2) -permeable channel activity when expressed in animal cells (150, 151).”
BackgroundLocke, E. G., Bonilla, M., Liang, L., Takita, Y., & Cunningham, K. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6686-6694.2000 · Cited by 212 · see citing works
Ozaki, K., Tanaka, K., Imamura, H., Hihara, T., Kameyama, T., Nonaka, H., Hirano, H., Matsuura, Y., & Takai, Y. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00573.x · Cited by 209 · see citing works
Zhao, C., Jung, U. S., Garrett-Engele, P., Roe, T., Cyert, M. S., & Levin, D. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.1013 · Cited by 209 · see citing works
Self-citationAlberts, A. S., Bouquin, N., Johnston, L. H., & Treisman, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8616 · Cited by 208 · see citing works
The Rho GTPase Rho3 Has a Direct Role in Exocytosis That Is Distinct from Its Role in Actin Polarity
Adamo, J. E., Rossi, G., & Brennwald, P. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.12.4121 · Cited by 208 · see citing works
The SPA2 protein of yeast localizes to sites of cell growth.
Snyder, M. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.4.1419 · Cited by 207 · see citing works
Tor2 Directly Phosphorylates the AGC Kinase Ypk2 To Regulate Actin Polarization
Kamada, Y., Fujioka, Y., Suzuki, N. N., Inagaki, F., Wullschleger, S., Loewith, R., Hall, M. N., & Ohsumi, Y. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7239-7248.2005 · Cited by 207 · see citing works
Characterization and Gene Cloning of 1,3-beta-D-Glucan Synthase from Saccharomyces Cerevisiae
Inoue, S., Takewakt, N., Takasuka, T., Mio, T., Adachi, M., Fujii, Y., Miyamoto, C., Arisawa, M., Furuichi, Y., & Watanabe, T. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0845d.x · Cited by 201 · see citing works
Ram, A. F. J., Kapteyn, J. C., Montijn, R. C., Caro, L. H. P., Douwes, J. E., Baginsky, W., Mazur, P., van den Ende, H., & Klis, F. M. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.6.1418-1424.1998 · Cited by 200 · see citing works
Watanabe, Y., Irie, K., & Matsumoto, K. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5740 · Cited by 198 · see citing works
Cell wall integrity modulates RHO1 activity via the exchange factor ROM2
Bickle, M., Delley, P., Schmidt, A., & Hall, M. N. (1998) · EMBO Journal · doi:10.1093/emboj/17.8.2235 · Cited by 198 · see citing works
Hori, Y., Kikuchi, A., Isomura, M., Katayama, M., Miura, Y., Fujioka, H., Kaibuchi, K., & Takai, Y. (1991) · PubMed · Cited by 197 · see citing works
Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast.
Peterson, J., Zheng, Y., Bender, L., Myers, A., Cerione, R., & Bender, A. (1994) · The Journal of cell biology · doi:10.1083/jcb.127.5.1395 · Cited by 197 · see citing works
Activity of 1,3-β-D-Glucan Synthase Requires the GTP-binding Protein Rho1
Mazur, P., & Baginsky, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14604 · Cited by 196 · see citing works
The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae.
Mazzoni, C., Zarov, P., Rambourg, A., et al. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.6.1821 · Cited by 196 · see citing works
Dodou, E., & Treisman, R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.1848 · Cited by 196 · see citing works
Yoshida, S., Ohya, Y., Goebl, M. G., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42237-x · Cited by 194 · see citing works
Mid2 Is a Putative Sensor for Cell Integrity Signaling in Saccharomyces cerevisiae
Rajavel, M., Philip, B., Buehrer, B. M., Errede, B., & Levin, D. E. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.3969 · Cited by 194 · see citing works
Self-citationSTT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo.
Zufferey, R., Knauer, R., Burda, P., Štagljar, I., Heesen, S. T., Lehle, L., & Aebi, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00178.x · Cited by 192 · see citing works
Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast
Poor, F., Parent, S. A., Morin, N. R., Dahl, A., Ramadan, N., Chrebet, G. L., Bostian, K. A., & NIELSEN, J. B. K. (1992) · Nature · doi:10.1038/360682a0 · Cited by 192 · see citing works
Robinson, N. G. G., Guo, L., Imai, J., Toh‐e, A., Matsui, Y., & Tamanoi, F. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3580 · Cited by 192 · see citing works
Watanabe, Y., Takaesu, G., Hagiwara, M., Irie, K., & Matsumoto, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2615 · Cited by 191 · see citing works
A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants
Torres, L., Martı́n, H., García-Sáez, M. I., Arroyo, J., Molina, M., Sánchez, M., & Nombela, C. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb01993.x · Cited by 191 · see citing works
Paidhungat, M., & Garrett, S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6339 · Cited by 191 · see citing works
ROLE OF SMALL G PROTEINS IN YEAST CELL POLARIZATION AND WALL BIOSYNTHESIS
Cabib, E., Drgonová, J., & Drgon, T. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.307 · Cited by 187 · see citing works
Garrett-Engele, P. W., Moilanen, B., & Cyert, M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4103 · Cited by 187 · see citing works
The <i>Saccharomyces cerevisiae</i> CCH1 gene is involved in calcium influx and mating
Fischer, M., Schnell, N., Chattaway, J., Davies, P., Dixon, G., & Sanders, D. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01466-x · Cited by 185 · see citing works
β‐1,6‐Glucan synthesis in Saccharomyces cerevisiae
Shahinian, S., & Bussey, H. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01713.x · Cited by 183 · see citing works
Li, S., Ault, A., Malone, C. L., Raitt, D. C., Dean, S., Johnston, L. H., Deschenes, R. J., & Fassler, J. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6952 · Cited by 183 · see citing works
BIM1Encodes a Microtubule-binding Protein in Yeast
Schwartz, K., Richards, K., & Botstein, D. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.12.2677 · Cited by 180 · see citing works
Roelants, F. M., Torrance, P. D., Bezman, N., & Thorner, J. W. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-04-0201 · Cited by 179 · see citing works
Yeast Respond to Hypotonic Shock with a Calcium Pulse
Batiza, A. F., Schulz, T., & Masson, P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23357 · Cited by 178 · see citing works
Raitt, D. C., Johnson, A. L., Erkine, A. M., Makino, K., Morgan, B. A., Gross, D. S., & Johnston, L. H. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.7.2335 · Cited by 176 · see citing works
The morphogenesis checkpoint: how yeast cells watch their figures
Lew, D. J. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.09.001 · Cited by 175 · see citing works
Rho-related proteins: actin cytoskeleton and cell cycle
Ridley, A. J. (1995) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(95)90049-7 · Cited by 174 · see citing works
Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast
Friant, S., Lombardi, R., Schmelzle, T., Hall, M. N., & Riezman, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.23.6783 · Cited by 173 · see citing works
TOR2 Is Part of Two Related Signaling Pathways Coordinating Cell Growth in Saccharomyces cerevisiae
Helliwell, S. B., Howald, I., Barbet, N., & Hall, M. N. (1998) · Genetics · doi:10.1093/genetics/148.1.99 · Cited by 171 · see citing works
Signal transduction by MAP kinase cascades in budding yeast
Posas, F., Takekawa, M., & Saito, H. (1998) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(98)80008-8 · Cited by 171 · see citing works
de Nadal, E., Casadomé, L., & Posas, F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.229-237.2003 · Cited by 171 · see citing works
Passage of molecules through yeast cell walls: A brief essay‐review
Nobel, J. G. D., & Barnett, J. A. (1991) · Yeast · doi:10.1002/yea.320070402 · Cited by 169 · see citing works
Valdivia, R. H., & Schekman, R. W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834246100 · Cited by 169 · see citing works
McMillan, J. N., Longtine, M. S., Sia, R. A. L., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.6929 · Cited by 168 · see citing works
Kapteyn, J. C., van Egmond, P., Sievi, E., ENDE, H. V. D., Makarow, M., & Klis, F. M. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01320.x · Cited by 168 · see citing works
Homma, K., Terui, S., Minemura, M., Qadota, H., Anraku, Y., Kanaho, Y., & Ohya, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15779 · Cited by 165 · see citing works
A Saccharomyces cerevisiae Genome-Wide Mutant Screen for Altered Sensitivity to K1 Killer Toxin
Pagé, N., Gérard‐Vincent, M., Ménard, P., Beaulieu, M., Azuma, M., Dijkgraaf, G. J. P., Li, H., Marcoux, J., Nguyen, T. N., Dowse, T., et al. (2003) · Genetics · doi:10.1093/genetics/163.3.875 · Cited by 165 · see citing works
Fujiwara, T., Tanaka, K., Mino, A., Kikyo, M., Takahashi, K., Shimizu, K., & Takai, Y. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.5.1221 · Cited by 165 · see citing works
Bonilla, M., & Cunningham, K. W. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-02-0113 · Cited by 165 · see citing works
The PCL2 (ORFD)-PHO85 Cyclin-Dependent Kinase Complex: a Cell Cycle Regulator in Yeast
Measday, V., Moore, L., Ogas, J., et al. (1994) · Science · doi:10.1126/science.7973731 · Cited by 163 · see citing works
A GDP Dissociation Inhibitor That Serves as a GTPase Inhibitor for the Ras-Like Protein CDC42Hs
Hart, M. J., Maru, Y., Leonard, D., Witte, O. N., Evans, T., & Cerione, R. A. (1992) · Science · doi:10.1126/science.1439791 · Cited by 163 · see citing works
Lipke, P. N., & Kurjan, J. (1992) · Microbiological Reviews · doi:10.1128/mr.56.1.180-194.1992 · Cited by 163 · see citing works
Kuroda, K. O., Yamamoto, Y., Nohara, H., Kinoshita, M., Fujiwara, T., Irie, K., & Takai, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.3.827-839.2001 · Cited by 161 · see citing works
Identification of a DNA binding factor involved in cell-cycle control of the yeast HO gene
Andrews, B., & Herskowitz, I. (1989) · Cell · doi:10.1016/0092-8674(89)90168-2 · Cited by 161 · see citing works
Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeast
Dong, Y., Pruyne, D., & Bretscher, A. P. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212040 · Cited by 160 · see citing works
Kopecká, M., & Gabriel, M. (1992) · Archives of Microbiology · doi:10.1007/bf00245214 · Cited by 159 · see citing works
Koch, C., Schleiffer, A., Ammerer, G., & Nasmyth, K. (1996) · Genes & Development · doi:10.1101/gad.10.2.129 · Cited by 159 · see citing works
Madania, A., Dumoulin, P., Grava, S., Kitamoto, H. K., Schaerer-Brodbeck, C., Soulard, A., Moreau, V., & Winsor, B. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3521 · Cited by 159 · see citing works
Bulik, D. A., Olczak, M., Lucero, H. A., Osmond, B. C., Robbins, P. W., & Specht, C. A. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.5.886-900.2003 · Cited by 159 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Fungal Cell Wall: Structure, Biosynthesis, and Function
Gow, N. A. R., Latge, J.-P., & Munro, C. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0035-2016 · Cited by 1,423 · see citing works
Cell Wall Assembly in <i>Saccharomyces cerevisiae</i>
Lesage, G., & Bussey, H. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00038-05 · Cited by 849 · see citing works
Antifungal Drug Resistance: Molecular Mechanisms in <i>Candida albicans</i> and Beyond
Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801 · see citing works
Verghese, J., Abrams, J., Wang, Y., & Morano, K. A. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05018-11 · Cited by 575 · see citing works
Regulatory circuitry governing fungal development, drug resistance, and disease.
Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576 · see citing works
Resistance to echinocandin-class antifungal drugs.
Perlin, D. S. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.04.002 · Cited by 512 · see citing works
Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins
Walker, L. A., Munro, C. A., de Bruijn, I., Lenardon, M. D., McKinnon, A., & Gow, N. A. R. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000040 · Cited by 445 · see citing works
LaFayette, S. L., Collins, C., Zaas, A. K., Schell, W. A., Betancourt-Quiroz, M., Gunatilaka, A. A. L., Perfect, J. R., & Cowen, L. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001069 · Cited by 329 · see citing works
Molecular mechanisms governing antifungal drug resistance
Lee, Y., Robbins, N., & Cowen, L. E. (2023) · npj Antimicrobials and Resistance · doi:10.1038/s44259-023-00007-2 · Cited by 304 · see citing works
Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.
Cowen, L. E., & Steinbach, W. J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00041-08 · Cited by 285 · see citing works
Fuchs, B. B., & Mylonakis, E. (2009) · Eukaryotic Cell · doi:10.1128/ec.00193-09 · Cited by 266 · see citing works
Fungal echinocandin resistance
Walker, L. A., Gow, N. A. R., & Munro, C. A. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.09.003 · Cited by 267 · see citing works
Plaine, A., Walker, L., Da Costa, G., Mora-Montes, H. M., McKinnon, A., Gow, N. A. R., Gaillardin, C., Munro, C. A., & Richard, M. L. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.08.003 · Cited by 238 · see citing works
Shingu-Vazquez, M., & Traven, A. (2011) · Eukaryotic Cell · doi:10.1128/ec.05184-11 · Cited by 209 · see citing works
Phylogenetic diversity of stress signalling pathways in fungi
Nikolaou, E., Agrafioti, I., Stumpf, M., Quinn, J., Stansfield, I., & Brown, A. J. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-44 · Cited by 206 · see citing works
Bermejo, C., Rodríguez, E., García, R., Rodríguez-Peña, J. M., Rodríguez de la Concepción, M. L., Rivas, C., Arias, P., Nombela, C., Posas, F., & Arroyo, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0742 · Cited by 204 · see citing works
An Extensive Circuitry for Cell Wall Regulation in Candida albicans
Blankenship, J. R., Fanning, S., Hamaker, J. J., & Mitchell, A. P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000752 · Cited by 201 · see citing works
Rho GTPases: regulation of cell polarity and growth in yeasts
Perez, P., & Rincón, S. A. (2010) · Biochemical Journal · doi:10.1042/bj20091823 · Cited by 162 · see citing works
Control of the C. albicans Cell Wall Damage Response by Transcriptional Regulator Cas5
Bruno, V. M., Kalachikov, S., Subaran, R., Nobile, C. J., Kyratsous, C., & Mitchell, A. P. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020021 · Cited by 157 · see citing works
Cell wall integrity signalling in human pathogenic fungi: CWI signalling in pathogenic fungi
Dichtl, K., Samantaray, S., & Wagener, J. (2016) · Cellular Microbiology · doi:10.1111/cmi.12612 · Cited by 144 · see citing works
Sorgo, A. G., Heilmann, C. J., Dekker, H. L., Bekker, M., Brul, S., de Koster, C. G., de Koning, L. J., & Klis, F. M. (2011) · Eukaryotic Cell · doi:10.1128/ec.05011-11 · Cited by 120 · see citing works
Genetic Drivers of Multidrug Resistance in Candida glabrata
Healey, K. R., Jimenez Ortigosa, C., Shor, E., & Perlin, D. S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01995 · Cited by 93 · see citing works
Hayes, B. M. E., Anderson, M. A., Traven, A., van der Weerden, N. L., & Bleackley, M. R. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1573-8 · Cited by 93 · see citing works
Survival in the Presence of Antifungals
Meyer, V., Damveld, R. A., Arentshorst, M., Stahl, U., van den Hondel, C. A. M. J. J., & Ram, A. F. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705856200 · Cited by 85 · see citing works
Robbins, N., Spitzer, M., Yu, T., Cerone, R. P., Averette, A. K., Bahn, Y.-S., Heitman, J., Sheppard, D. C., Tyers, M., & Wright, G. D. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.018 · Cited by 78 · see citing works
<i>UPC2</i> Is Universally Essential for Azole Antifungal Resistance in Candida albicans
Vasicek, E. M., Berkow, E. L., Flowers, S. A., Barker, K. S., & Rogers, P. D. (2014) · Eukaryotic Cell · doi:10.1128/ec.00221-13 · Cited by 71 · see citing works
Liu, M., Du, P., Heinrich, G., Cox, G. M., & Gelli, A. (2006) · Eukaryotic Cell · doi:10.1128/ec.00158-06 · Cited by 76 · see citing works
A yeast MAPK cascade regulates pexophagy but not other autophagy pathways
Manjithaya, R., Jain, S., Farré, J.-C., & Subramani, S. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200909154 · Cited by 72 · see citing works
Miyazaki, T., Inamine, T., Yamauchi, S., Nagayoshi, Y., Saijo, T., Izumikawa, K., Seki, M., Kakeya, H., Yamamoto, Y., Yanagihara, K., et al. (2010) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2010.00611.x · Cited by 70 · see citing works
Truman, A. W., Millson, S. H., Nuttall, J. M., Mollapour, M., Prodromou, C., & Piper, P. W. (2007) · Eukaryotic Cell · doi:10.1128/ec.00009-07 · Cited by 59 · see citing works
Gregori, C., Schüller, C., Roetzer, A., Schwarzmüller, T., Ammerer, G., & Kuchler, K. (2007) · Eukaryotic Cell · doi:10.1128/ec.00106-07 · Cited by 57 · see citing works
Borah, S., Shivarathri, R., & Kaur, R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.264671 · Cited by 44 · see citing works
Avrahami-Moyal, L., Engelberg, D., Wenger, J. W., Sherlock, G., & Braun, S. (2012) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2012.00803.x · Cited by 43 · see citing works
Badrane, H., Nguyen, M. H., Blankenship, J. R., Cheng, S., Hao, B., Mitchell, A. P., & Clancy, C. J. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00112-12 · Cited by 38 · see citing works
Zhang, Y., Zeng, L., Huang, X., Wang, Y., Chen, G., Moses, M., Zou, Y., Xiong, S., Xue, W., Dong, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59898-6 · Cited by 33 · see citing works
“Moreover, the transcription factor Cas5 acts as a regulator of resistance to the echi-nocandin caspofungin in C. albicans , with studies showing that genes regulated by Cas5 in response to cell wall stress are also linked to calcineurin 48,51,52 .”
Buu, L.-M., & Chen, Y.-C. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-101 · Cited by 27 · see citing works
Tanaka, Y., Sasaki, M., Ito, F., Aoyama, T., Sato-Okamoto, M., Takahashi-Nakaguchi, A., Chibana, H., & Shibata, N. (2018) · Fungal Biology · doi:10.1016/j.funbio.2017.09.007 · Cited by 13 · see citing works
- Authors
- Levin, D. E.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Levin, David E.
- ORCID
- Levin, David E.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2005-06
- Volume
- 69
- Issue
- 2
- Pages
- 262-291
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- PMC
- PMC1197416
- OpenAlex
- W2157937554
- Cited by
- 1,136
- References
- 393
- Citations by year
- 2026: 35 · 2025: 34 · 2024: 45 · 2023: 32 · 2022: 43 · 2021: 44 · 2020: 36 · 2019: 48 · 2018: 51 · 2017: 40 · 2016: 48 · 2015: 49 · 2014: 66 · 2013: 53 · 2012: 76
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM48533, R01GM048533)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- cell wall integrity signaling, Saccharomyces cerevisiae, cell wall stress, osmotic stress, cell wall expansion, polarized secretion, calcium signaling, phosphoinositide signaling, Cdc42, cell wall biosynthesis, transcriptional regulation
- MeSH terms
- Cell Wall, Enzyme Activation, Protein Kinase C, Saccharomyces cerevisiae, Signal Transduction, Drug Delivery Systems, rho GTP-Binding Proteins, Mitogen-Activated Protein Kinases, Saccharomyces cerevisiae Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review