The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
A Surface Protease and the Invasive Character of Plague
Abstract
A 9.5-kilobase plasmid of Yersinia pestis , the causative agent of plague, is required for high virulence when mice are inoculated with the bacterium by subcutaneous injection. Inactivation of the plasmid gene pla , which encodes a surface protease, increased the median lethal dose of the bacteria for mice by a millionfold. Moreover, cloned pla was sufficient to restore segregants lacking the entire pla - bearing plasmid to full virulence. Both pla + strains injected subcutaneously and pla - mutants injected intravenously reached high titers in liver and spleen of infected mice, whereas pla - mutants injected subcutaneously failed to do so even though they establish a sustained local infection at the injection site. More inflammatory cells accumulated in lesions caused by the pla - mutants than in lesions produced by the pla + parent. The Pla protease was shown to be a plasminogen activator with unusual kinetic properties. It can also cleave complement C3 at a specific site.
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Cites
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Cited by
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Plasminogen is a critical host pathogenicity factor for group A streptococcal infection
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Metadata
- Authors
- Sodeinde, O. A., Subrahmanyam, Y. V. B. K., Stark, K., Quan, T., Bao, Y., & Goguen, J. D.
- Venue
- Science
- Published
- 1992-11-06
- Volume
- 258
- Issue
- 5084
- Pages
- 1004-1007
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014477644
- Cited by
- 503
- References
- 11
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sodeinde, O. A., Subrahmanyam, Y. V. B. K., Stark, K., Quan, T., Bao, Y., & Goguen, J. D. (1992). A Surface Protease and the Invasive Character of Plague. Science. https://doi.org/10.1126/science.1439793
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
