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A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma
Abstract
Summary: An indirect spectrophotometric assay for extrinsic plasminogen activator has been devised, which is based on the parabolic assay of Drapier et al. (5). The system contains activator, plasminogen, the synthetic plasmin substrate H-D-Val-Leu-Lys-pNA (S-2251, Kabi) and a mixture of soluble fibrinogen fragments prepared by treatment of fibrinogen with cyanogen bromide. The addition of these fibrinogen fragments considerably enhances the sensitivity and specificity of the method owing to specific stimulation of the plasminogen activation by extrinsic plasminogen activator. The assay conditions were optimized and the application for extrinsic plasminogen activator measurements in plasma euglobulin fractions is demonstrated.
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Cited by
A Surface Protease and the Invasive Character of Plague
Sodeinde, O. A., Subrahmanyam, Y. V. B. K., Stark, K., Quan, T., Bao, Y., & Goguen, J. D. (1992) · Science · doi:10.1126/science.1439793 · Cited by 503
Jebb, S. A., Lovegrove, J. A., Griffin, B. A., Frost, G. S., Moore, C. S., Chatfield, M. D., Bluck, L. J., Williams, C. M., & Sanders, T. A. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29096 · Cited by 192
VAN WESTERLOO, D. J., GIEBELEN, I. A. J., MEIJERS, J. C. M., DAALHUISEN, J., DE VOS, A. F., LEVI, M., & VAN DER POLL, T. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02112.x · Cited by 84
Metadata
- Authors
- Verheijen, J. H., Mullaart, E., Chang, G. T. G., Kluft, C., & Wijngaards, G.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1982
- Volume
- 48
- Issue
- 03
- Pages
- 266-269
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2415114669
- Cited by
- 475
- References
- 0
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma. https://app.cochat.ai/papers/10.1055/s-0038-1657277
- The paper
- Verheijen, J. H., Mullaart, E., Chang, G. T. G., Kluft, C., & Wijngaards, G. (1982). A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0038-1657277
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
