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B Cells Turn Off Virgin But Not Memory T Cells
Open accessAbstract
There are three possible outcomes when a T cell recognizes a cell bearing a self or foreign antigen. (i) The T cell is not sufficiently signaled and is unaffected. (ii) The T cell is activated. (iii) The T cell is turned off. The differentiation state of the T cell is critical to the outcome. Although both virgin and memory T cells can be activated by antigens presented by "professional" antigen-presenting cells such as dendritic cells, they differ in their responses to B cells. Experienced T cells respond to antigen presented by B cells, whereas virgin T cells are rendered tolerant. These findings may relate to the phenomena of low- and high-zone tolerance, neonatal tolerance, and the beneficial effect of blood transfusions on allograft survival.
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Cited by
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978
Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells
Ridge, J. P., Fuchs, E. J., & Matzinger, P. (1996) · Science · doi:10.1126/science.271.5256.1723 · Cited by 760
Self-citationExperimental Autoimmune Encephalomyelitis Induction in Genetically B Cell–deficient Mice
Wolf, S. D., Dittel, B. N., Hardardottir, F., & Janeway, C. A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2271 · Cited by 699
Identification of a B cell signature associated with renal transplant tolerance in humans
Newell, K. A., Asare, A., Kirk, A. D., Gisler, T. D., Bourcier, K., Suthanthiran, M., Burlingham, W. J., Marks, W. H., Sanz, I., Lechler, R. I., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39933 · Cited by 678
Cerebral Vasospasm after Subarachnoid Hemorrhage: Putative Role of Inflammation
Dumont, A. S., Dumont, R. J., Chow, M. M., Lin, C.-L., Calisaneller, T., Ley, K. F., Kassell, N. F., & Lee, K. S. (2003) · Neurosurgery · doi:10.1227/01.neu.0000068863.37133.9e · Cited by 441
Metadata
- Authors
- Fuchs, E. J., & Matzinger, P.
- Venue
- Science
- Published
- 1992-11-13
- Volume
- 258
- Issue
- 5085
- Pages
- 1156-1159
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038574124
- Cited by
- 562
- References
- 0
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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