The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Identification of a B cell signature associated with renal transplant tolerance in humans
Open accessAbstract
Establishing long-term allograft acceptance without the requirement for continuous immunosuppression, a condition known as allograft tolerance, is a highly desirable therapeutic goal in solid organ transplantation. Determining which recipients would benefit from withdrawal or minimization of immunosuppression would be greatly facilitated by biomarkers predictive of tolerance. In this study, we identified the largest reported cohort to our knowledge of tolerant renal transplant recipients, as defined by stable graft function and receiving no immunosuppression for more than 1 year, and compared their gene expression profiles and peripheral blood lymphocyte subsets with those of subjects with stable graft function who are receiving immunosuppressive drugs as well as healthy controls. In addition to being associated with clinical and phenotypic parameters, renal allograft tolerance was strongly associated with a B cell signature using several assays. Tolerant subjects showed increased expression of multiple B cell differentiation genes, and a set of just 3 of these genes distinguished tolerant from nontolerant recipients in a unique test set of samples. This B cell signature was associated with upregulation of CD20 mRNA in urine sediment cells and elevated numbers of peripheral blood naive and transitional B cells in tolerant participants compared with those receiving immunosuppression. These results point to a critical role for B cells in regulating alloimmunity and provide a candidate set of genes for wider-scale screening of renal transplant recipients.
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Messenger RNA for FOXP3 in the Urine of Renal-Allograft Recipients
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Self-citationDevelopment of a cross-platform biomarker signature to detect renal transplant tolerance in humans
Sagoo, P., Perucha, E., Sawitzki, B., Tomiuk, S., Stephens, D. A., Miqueu, P., Chapman, S., Craciun, L., Sergeant, R., Brouard, S., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39922 · Cited by 528
Self-citationRegulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance
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Self-citationWEANING OF IMMUNOSUPPRESSION IN LIVER TRANSPLANT RECIPIENTS12
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Cited by
Flores-Borja, F., Bosma, A., Ng, D., Reddy, V., Ehrenstein, M. R., Isenberg, D. A., & Mauri, C. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005407 · Cited by 688
Hoffman, W., Lakkis, F. G., & Chalasani, G. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09430915 · Cited by 482
Mechanisms of Rejection: Current Perspectives
Wood, K. J., & Goto, R. (2012) · Transplantation · doi:10.1097/tp.0b013e31823cab44 · Cited by 369
Effector Mechanisms of Rejection
Moreau, A., Varey, E., Anegon, I., & Cuturi, M.-C. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015461 · Cited by 189
Human allograft rejection in humanized mice: a historical perspective
Brehm, M. A., & Shultz, L. D. (2012) · Cellular & Molecular Immunology · doi:10.1038/cmi.2011.64 · Cited by 30
Metadata
- Authors
- Newell, K. A., Asare, A., Kirk, A. D., Gisler, T. D., Bourcier, K., Suthanthiran, M., Burlingham, W. J., Marks, W. H., Sanz, I., Lechler, R. I., Hernandez-Fuentes, M. P., Turka, L. A., & Seyfert-Margolis, V. L.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-06-01
- Volume
- 120
- Issue
- 6
- Pages
- 1836-1847
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2137442990
- Cited by
- 678
- References
- 41
- FWCI
- 46.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Newell, K. A., Asare, A., Kirk, A. D., Gisler, T. D., Bourcier, K., Suthanthiran, M., Burlingham, W. J., Marks, W. H., Sanz, I., Lechler, R. I., Hernandez-Fuentes, M. P., Turka, L. A., & Seyfert-Margolis, V. L. (2010). Identification of a B cell signature associated with renal transplant tolerance in humans. Journal of Clinical Investigation. https://doi.org/10.1172/jci39933
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