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Waterfall Sequence for Intrinsic Blood Clotting
Abstract
A simple waterfall sequence is proposed to explain the function of the various protein clotting factors during the formation of the fibrin clot. When clotting is initiated, each clotting factor except fibrinogen is converted to a form that has enzymatic activity. This activation occurs in a stepwise sequence with each newly formed enzyme reacting with its specific substrate, converting it to an active enzyme.
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Citations
Cited by
Mechanisms of Thrombus Formation
Furie, B., & Furie, B. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801082 · Cited by 1,926
A Cell-based Model of Hemostasis
Monroe, D., & Hoffman, M. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615947 · Cited by 1,542
Thrombin activation of the factor XI dimer is a multi-staged process for each subunit
Barroeta, A. B., Albanese, P., Marquart, J. A., Meijers, J. C. M., & Scheltema, R. A. (2023) · doi:10.1101/2023.02.11.528103 · Cited by 1
Metadata
- Authors
- Davie, E. W., & Ratnoff, O. D.
- Venue
- Science
- Published
- 1964-09-18
- Volume
- 145
- Issue
- 3638
- Pages
- 1310-1312
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059991147
- Cited by
- 1,113
- References
- 0
- FWCI
- 23.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Waterfall Sequence for Intrinsic Blood Clotting. https://app.cochat.ai/papers/10.1126/science.145.3638.1310
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- Davie, E. W., & Ratnoff, O. D. (1964). Waterfall Sequence for Intrinsic Blood Clotting. Science. https://doi.org/10.1126/science.145.3638.1310
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
