The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A Cell-based Model of Hemostasis
Abstract
Summary: Based on our work and that of many other workers, we have developed a model of coagulation in vivo. Many workers have demonstrated mechanisms by which cells can influence the coagulation process. Nonetheless, the prevailing view of hemostasis remains that the protein coagulation factors direct and control the process with cells serving primarily to provide a phosphatidylserine containing surface on which the procoagulant complexes are assembled. By contrast, we propose a model in which coagulation is regulated by properties of cell surfaces. This model emphasizes the importance of specific cellular receptors for the coagulation proteins. Thus, cells with similar phosphatidylserine content can play very different roles in hemostasis depending on their complement of surface receptors. We propose that coagulation occurs not as a “cascade”, but in three overlapping stages: 1) initiation, which occurs on a tissue factor bearing cell; 2) amplification, in which platelets and cofactors are activated to set the stage for large scale thrombin generation; and 3) propagation, in which large amounts of thrombin are generated on the platelet surface. This cell based model explains some aspects of hemostasis that a protein-centric model does not.
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Citations
Cites
An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier
MACFARLANE, R. G. (1964) · Nature · doi:10.1038/202498a0 · Cited by 1,119
Waterfall Sequence for Intrinsic Blood Clotting
Davie, E. W., & Ratnoff, O. D. (1964) · Science · doi:10.1126/science.145.3638.1310 · Cited by 1,113
Blood-borne tissue factor: Another view of thrombosis
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Osterud, B., & Rapaport, S. I. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5260 · Cited by 787
Factor XI Activation in a Revised Model of Blood Coagulation
Gailani, D., & Broze, G. J. (1991) · Science · doi:10.1126/science.1652157 · Cited by 775
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
Banner, D. W., D'Arcy, A., Chène, C., Winkler, F. K., Guha, A., Konigsberg, W. H., Nemerson, Y., & Kirchhofer, D. (1996) · Nature · doi:10.1038/380041a0 · Cited by 731
Changes in membrane phospholipid distribution during platelet activation
Bevers, E. M., Comfurius, P., & Zwaal, R. F. A. (1983) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(83)90169-4 · Cited by 558
Platelet activity of high‐dose factor VIIa is independent of tissue factor
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Self-citationStearns-Kurosawa, D. J., Kurosawa, S., Mollica, J. S., Ferrell, G. L., & Esmon, C. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10212 · Cited by 528
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Cited by
Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing
Pourshahrestani, S., Zeimaran, E., Kadri, N. A., Mutlu, N., & Boccaccini, A. R. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000905 · Cited by 448
Cardiovascular Manifestations of Hypereosinophilic Syndromes
Ogbogu, P. U., Rosing, D. R., & Horne, M. K. (2007) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2007.07.001 · Cited by 375
Pathophysiology and Treatment of Coagulopathy in Massive Hemorrhage and Hemodilution
Bolliger, D., Görlinger, K., Tanaka, K. A., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181f22b5a · Cited by 325
Biological effects of space radiation and development of effective countermeasures
Kennedy, A. R. (2014) · Life Sciences in Space Research · doi:10.1016/j.lssr.2014.02.004 · Cited by 188
Cutaneous wound healing is impaired in hemophilia B
Hoffman, M., Harger, A., Lenkowski, A., Hedner, U., Roberts, H. R., & Monroe, D. M. (2006) · Blood · doi:10.1182/blood-2006-05-020495 · Cited by 117
Self-citation
Metadata
- Authors
- Monroe, D., & Hoffman, M.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2001
- Volume
- 85
- Issue
- 06
- Pages
- 958-965
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2127414127
- Cited by
- 1,542
- References
- 27
- FWCI
- 13.70
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
