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Consequences of Replication Fork Movement Through Transcription Units in Vivo
Abstract
To examine the basis for the evolutionary selection for codirectionality of replication and transcription in Escherichia coli , electron microscopy was used to visualize replication from an inducible ColE1 replication origin inserted into the Escherichia coli chromosome upstream (5′) or downstream (3′) of rrnB , a ribosomal RNA operon. Active rrnB operons were replicated either in the same direction in which they were transcribed or in the opposite direction. In either direction, RNA polymerases were dislodged during replication. When replication and transcription were codirectional, the rate of replication fork movement was similar to that observed in nontranscribed regions. When replication and transcription occurred in opposite directions, replication fork movement was reduced.
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Citations
Cites
Progression of the cell cycle through mitosis leads to abortion of nascent transcripts
Shermoen, A. W., & O'Farrell, P. H. (1991) · Cell · doi:10.1016/0092-8674(91)90182-x · Cited by 360
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Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
Fraser, C. M., Casjens, S., Huang, W. M., Sutton, G. G., Clayton, R., Lathigra, R., White, O., Ketchum, K. A., Dodson, R., Hickey, E. K., et al. (1997) · Nature · doi:10.1038/37551 · Cited by 2,108
Replication fork stalling at natural impediments
Mirkin, E. V., & Mirkin, S. M. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00030-06 · Cited by 482
Aguilera, A., & García-Muse, T. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133232 · Cited by 476
BASIC MECHANISMS OF TRANSCRIPT ELONGATION AND ITS REGULATION
Uptain, S. M., Kane, C. M., & Chamberlin, M. J. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.117 · Cited by 445
Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place
Kotsantis, P., Petermann, E., & Boulton, S. J. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1461 · Cited by 416
Metadata
- Authors
- French, S.
- Venue
- Science
- Published
- 1992-11-20
- Volume
- 258
- Issue
- 5086
- Pages
- 1362-1365
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993973779
- Cited by
- 259
- References
- 1
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
