Replication fork stalling at natural impediments

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366 · see citing works

The complete genome sequence of Escherichia coli K-12.

Blattner, F., Plunkett, G., Bloch, C., Perna, N., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C., Mayhew, G., et al. (1997) · Science · doi:10.1126/science.277.5331.1453 · Cited by 7,996 · see citing works

DNA Repair and Mutagenesis

Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683 · see citing works

Comprehensive Identification of Cell Cycle–regulated Genes of the YeastSaccharomyces cerevisiaeby Microarray Hybridization

Spellman, P. T., Sherlock, G. J., Zhang, M. Q., Iyer, V. R., Anders, K. R., Eisen, M. B., Brown, P. O., Botstein, D., & Futcher, B. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.12.3273 · Cited by 4,724 · see citing works

Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology

Neidhardt, F. C., & Ingraham, J. L. (1987) · Medical Entomology and Zoology · Cited by 4,089 · see citing works

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481 · see citing works

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Shah, M. A., Datson, N. A., Srinidhi, L., Stanton, V. P., MacDonald, M. E., Allard, M. W., Youngman, S., Am, F., Mott, R., Draths, K., et al. (1993) · Cell · Cited by 3,055 · see citing works

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,857 · see citing works

Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

Campuzano, V., Montermini, L., Moltò, M. D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Rodius, F., Duclos, F., Monticelli, A., et al. (1996) · Science · doi:10.1126/science.271.5254.1423 · Cited by 2,786 · see citing works

Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member

Brook, J. D., McCurrach, M. E., Harley, H. G., Buckler, A., Church, D. M., Aburatani, H., Hunter, K. W., Stanton, V. P., Thirion, J., Hudson, T. J., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90154-5 · Cited by 2,754 · see citing works

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

Ionov, Y., Peinado, M. A., Malkhosyan, S. R., Shibata, D. K., & Perucho, M. (1993) · Nature · doi:10.1038/363558a0 · Cited by 2,691 · see citing works

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R. E., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Nyström, M., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90330-s · Cited by 2,271 · see citing works

Multiple Pathways of Recombination Induced by Double-Strand Breaks in <i>Saccharomyces cerevisiae</i>

Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120 · see citing works

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, C., Lipford, J. R., Lindblom, A., et al. (1994) · Nature · doi:10.1038/368258a0 · Cited by 2,050 · see citing works

A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle

Cho, R. J., Campbell, M. J., Winzeler, E. A., Steinmetz, L. M., Conway, A. R., Wodicka, L. M., Wolfsberg, T. G., Gabrielian, A. E., Landsman, D., Lockhart, D. J., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80114-8 · Cited by 2,024 · see citing works

Supercoiling of the DNA template during transcription.

Liu, L. F., & Wang, J. C. (1987) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.84.20.7024 · Cited by 1,877 · see citing works

Mutation of a mutL Homolog in Hereditary Colon Cancer

Papadopoulos, N., Nicolaides, N. C., Wei, Y.-F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., et al. (1994) · Science · doi:10.1126/science.8128251 · Cited by 1,822 · see citing works

Myotonic Dystrophy Mutation: an Unstable CTG Repeat in the 3′ Untranslated region of the Gene

Mahadevan, M. S., Tsilfidis, C., Sabourin, L. A., Shutler, G., Amemiya, C. T., Jansen, G., Neville, C., Narang, M. A., Barceló, J. M., O'Hoy, K., et al. (1992) · Science · doi:10.1126/science.1546325 · Cited by 1,656 · see citing works

Elevated recombination rates in transcriptionally active DNA

Thomas, B. J., & Rothstein, R. J. (1989) · Cell · doi:10.1016/0092-8674(89)90584-9 · Cited by 1,633 · see citing works

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

Nicolaides, N. C., Papadopoulos, N., Liu, B., Weit, Y.-F., Carter, K. C., Ruben, S. M., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., et al. (1994) · Nature · doi:10.1038/371075a0 · Cited by 1,543 · see citing works

Myotonic Dystrophy Type 2 Caused by a CCTG Expansion in Intron 1 of ZNF9

Liquori, C. L., Ricker, K., Moseley, M. L., Jacobsen, J. F., Kreß, W., Naylor, S. L., Day, J., & Ranum, L. P. W. (2001) · Science · doi:10.1126/science.1062125 · Cited by 1,230 · see citing works

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

MELLON, I. (1987) · Cell · doi:10.1016/0092-8674(87)90151-6 · Cited by 1,228 · see citing works

Monovalent cation-induced structure of telomeric DNA: The G-quartet model

Williamson, J. R., Raghuraman, M. K., & Cech, T. R. (1989) · Cell · doi:10.1016/0092-8674(89)90610-7 · Cited by 1,228 · see citing works

THE CHEMISTRY AND BIOLOGY OF LEFT-HANDED Z-DNA

Rich, A. S., Nordheim, A., & Wang, A. H. ‐. (1984) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.53.070184.004043 · Cited by 1,177 · see citing works

Hypermutability and mismatch repair deficiency in RER+ tumor cells

Parsons, R. E., Li, G., Longley, M. J., Fang, W.-H., Papadopoulos, N., Jen, J., de la Chapelle, A., Kinzler, K. W., Vogelstein, B., & Modrich, P. L. (1993) · Cell · doi:10.1016/0092-8674(93)90331-j · Cited by 1,054 · see citing works

The localization of replication origins on ARS plasmids in S. cerevisiae

Brewer, B. J., & Fangman, W. L. (1987) · Cell · doi:10.1016/0092-8674(87)90642-8 · Cited by 1,052 · see citing works

The importance of repairing stalled replication forks

Cox, M. M., Goodman, M. F., Kreuzer, K. N., Sherratt, D. J., Sandler, S. J., & Marians, K. J. (2000) · Nature · doi:10.1038/35003501 · Cited by 1,044 · see citing works

Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n

Kremer, E., Pritchard, M., Lynch, M., Yu, S., Holman, K., Baker, E., Warren, S., Schlessinger, D., Sutherland, G., & Richards, R. (1991) · Science · doi:10.1126/science.1675488 · Cited by 929 · see citing works

Repeat instability: mechanisms of dynamic mutations

Pearson, C. E., Edamura, K. N., & Cleary, J. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1689 · Cited by 924 · see citing works

Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

Sogo, J. M., Lopes, M., & Foiani, M. (2002) · Science · doi:10.1126/science.1074023 · Cited by 824 · see citing works

The stringent response

Cashel, M. (1996) · Medical Entomology and Zoology · Cited by 819 · see citing works

THE DNA REPLICATION FORK IN EUKARYOTIC CELLS

Waga, S., & Stillman, B. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.721 · Cited by 814 · see citing works

DNA Structure and Function

Coyle, H. M. (2004) · CRC Press eBooks · doi:10.1201/9780203484593-10 · Cited by 787 · see citing works

The DNA replication checkpoint response stabilizes stalled replication forks

Lopes, M., Cotta‐Ramusino, C., Pellicioli, A., Liberi, G., Plevani, P., Muzi-Falconi, M., Newlon, C. S., & Foiani, M. (2001) · Nature · doi:10.1038/35087613 · Cited by 749 · see citing works

Transcription generates positively and negatively supercoiled domains in the template

Wu, H.-Y., Shyy, S., Wang, J. C., & Liu, L. F. (1988) · Cell · doi:10.1016/0092-8674(88)90163-8 · Cited by 744 · see citing works

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

Bell, G. I., Horita, S., & Karam, J. H. (1984) · Diabetes · doi:10.2337/diab.33.2.176 · Cited by 744 · see citing works

Repeat instability : mechanisms of dynamic mutations

Pearson, C. E. (2005) · Medical Entomology and Zoology · Cited by 711 · see citing works

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

Yancopoulos, G. D. (1985) · Cell · doi:10.1016/0092-8674(85)90141-2 · Cited by 696 · see citing works

Initiation of genetic recombination and recombination-dependent replication

Kowalczykowski, S. C. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01569-3 · Cited by 674 · see citing works

Mechanism and control of meiotic recombination initiation

Keeney, S. (2001) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(01)52008-6 · Cited by 652 · see citing works

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

Katou, Y., Kanoh, Y., Bando, M., Noguchi, H., Tanaka, H., Ashikari, T., Sugimoto, K., & Shirahige, K. (2003) · Nature · doi:10.1038/nature01900 · Cited by 649 · see citing works

DNA replication, 2nd edn

Lilley, D. M. J. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90410-b · Cited by 574 · see citing works

Trinucleotide repeats that expand in human disease form hairpin structures in vitro

Gacy, A. M., Goellner, G. M., Juranić, N., Macura, S. I., & McMurray, C. T. (1995) · Cell · doi:10.1016/0092-8674(95)90074-8 · Cited by 569 · see citing works

Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions

Lopes, M., Foiani, M., & Sogo, J. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.015 · Cited by 563 · see citing works

ATR Regulates Fragile Site Stability

Casper, A. M., Nghiem, P., Arlt, M. F., & Glover, T. W. (2002) · Cell · doi:10.1016/s0092-8674(02)01113-3 · Cited by 559 · see citing works

A replication fork barrier at the 3′ end of yeast ribosomal RNA genes

Brewer, B. J., & Fangman, W. L. (1988) · Cell · doi:10.1016/0092-8674(88)90222-x · Cited by 552 · see citing works

RuvAB Acts at Arrested Replication Forks

Seigneur, M., Bidnenko, V., Ehrlich, S. D., & Michel, B. (1998) · Cell · doi:10.1016/s0092-8674(00)81772-9 · Cited by 538 · see citing works

Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10

Matsuura, T., Yamagata, T., Burgess, D., Rasmussen, A., Grewal, R., Watase, K., Khajavi, M., McCall, A., Davis, C., Zu, L., et al. (2000) · Nature Genetics · doi:10.1038/79911 · Cited by 522 · see citing works

Mrc1 transduces signals of DNA replication stress to activate Rad53

Alcasabas, A. A., Osborn, A. J., Bachant, J., Hu, F., Werler, P., Bousset, K., Furuya, K., Diffley, J. F. X., Carr, A. M., & Elledge, S. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-958 · Cited by 516 · see citing works

Formation of an RNA primer for initiation of replication of ColE1 DNA by ribonuclease H.

Itoh, T., & Tomizawa, J.-I. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2450 · Cited by 509 · see citing works

Transcription-Coupled Repair and Human Disease

Hanawalt, P. C. (1994) · Science · doi:10.1126/science.7801121 · Cited by 496 · see citing works

Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae

Gerton, J. L., DeRisi, J. L., Shroff, R., Lichten, M., Brown, P. O., & Petes, T. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11383 · Cited by 481 · see citing works

Maintenance of Genome Stability in Saccharomyces cerevisiae

Kolodner, R. D., Putnam, C. D., & Myung, K. (2002) · Science · doi:10.1126/science.1075277 · Cited by 464 · see citing works

Meiosis-Induced Double-Strand Break Sites Determined by Yeast Chromatin Structure

Wu, T.-C., & Lichten, M. (1994) · Science · doi:10.1126/science.8290959 · Cited by 448 · see citing works

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathwayPreprint

Desany, B. A., Alcasabas, A. A., Bachant, J. B., & Elledge, S. J. (1998) · Genes & Development · doi:10.1101/gad.12.18.2956 · Cited by 448 · see citing works

A model for replication repair in mammalian cells

Higgins, N. P., Kato, K., & Strauss, B. S. (1976) · Journal of Molecular Biology · doi:10.1016/0022-2836(76)90156-x · Cited by 444 · see citing works

ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

Rita, S., & Kleckner, N. E. (2002) · Science · doi:10.1126/science.1071398 · Cited by 429 · see citing works

Mismatch Repair, Genetic Stability, and Cancer

Modrich, P. L. (1994) · Science · doi:10.1126/science.7801122 · Cited by 424 · see citing works

MATING-TYPE GENE SWITCHING IN SACCHAROMYCES CEREVISIAE

Haber, J. E. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.561 · Cited by 410 · see citing works

The Saccharomyces cerevisiae Helicase Rrm3p Facilitates Replication Past Nonhistone Protein-DNA Complexes

Ivessa, A., Lenzmeier, B. A., Bessler, J. B., Goudsouzian, L. K., Schnakenberg, S. L., & Zakian, V. A. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00456-8 · Cited by 407 · see citing works

Expansion and Length-Dependent Fragility of CTG Repeats in Yeast

Freudenreich, C. H., Kantrow, S. M., & Zakian, V. A. (1998) · Science · doi:10.1126/science.279.5352.853 · Cited by 403 · see citing works

Elimination of Replication Block Protein Fob1 Extends the Life Span of Yeast Mother Cells

Defossez, P., Prusty, R., Kaeberlein, M. R., Lin, S.-J., Ferrigno, P. K., Silver, P. A., Keil, R., & Guarente, L. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80472-4 · Cited by 401 · see citing works

Recombinational repair and restart of damaged replication forks

McGlynn, P., & Lloyd, R. G. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm951 · Cited by 397 · see citing works

TRINUCLEOTIDE REPEAT EXPANSION AND HUMAN DISEASE

Ashley, C. T., & Warren, S. T. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.003415 · Cited by 395 · see citing works

A Central Role for DNA Replication Forks in Checkpoint Activation and Response

Tercero, J. A., Longhese, M. P., & Diffley, J. F. X. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00169-2 · Cited by 394 · see citing works

Dynamic organization of chromosomal DNA in Escherichia coliPreprint

Niki, H., Yamaichi, Y., & Hiraga, S. (2000) · Genes & Development · doi:10.1101/gad.14.2.212 · Cited by 391 · see citing works

Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase IPreprint

Kobayashi, T., Heck, D. J., Nomura, M., & Horiuchi, T. (1998) · Genes & Development · doi:10.1101/gad.12.24.3821 · Cited by 389 · see citing works

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombePreprint

Lindsay, H. D., Griffiths, D. J. F., Edwards, R. J., Christensen, P. U., Murray, J. M., Osman, F., Walworth, N. C., & Carr, A. M. (1998) · Genes & Development · doi:10.1101/gad.12.3.382 · Cited by 385 · see citing works

When polymerases collide: Replication and the transcriptional organization of the E. coli chromosome

Brewer, B. J. (1988) · Cell · doi:10.1016/0092-8674(88)90086-4 · Cited by 377 · see citing works

Organization of replication of ribosomal DNA in Saccharomyces cerevisiae.

Linskens, M. H. K., & Huberman, J. A. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.11.4927 · Cited by 373 · see citing works

MEIOTIC RECOMBINATION HOTSPOTS

Lichten, M., & Goldman, A. S. H. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.002231 · Cited by 372 · see citing works

DNA Replication Fork Pause Sites Dependent on Transcription

Deshpande, A. M., & Newlon, C. S. (1996) · Science · doi:10.1126/science.272.5264.1030 · Cited by 370 · see citing works

Cryptic and polar variation of the fragile X repeat could result in predisposing normal alleles

Kunst, C. B. (1994) · Cell · doi:10.1016/0092-8674(94)90134-1 · Cited by 361 · see citing works

Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli

Kang, S., Jaworski, A., Ohshima, K., & Wells, R. D. (1995) · Nature Genetics · doi:10.1038/ng0695-213 · Cited by 355 · see citing works

Dodecamer repeat expansion in cystatin B gene in progressive myoclonus epilepsy

Lalioti, M. D., Scott, H. S., Burési, C., Rossier, C., Bottani, A., Morris, M. A., Malafosse, A., & Antonarakis, S. E. (1997) · Nature · doi:10.1038/386847a0 · Cited by 353 · see citing works

Priming of human mitochondrial DNA replication occurs at the light-strand promoter.

Chang, D. D., & Clayton, D. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.351 · Cited by 349 · see citing works

Trinucleotide repeats affect DNA replication in vivo

Samadashwily, G., Raca, G., & Mirkin, S. (1997) · Nature Genetics · doi:10.1038/ng1197-298 · Cited by 343 · see citing works

DNA PROCESSING REACTIONS IN BACTERIAL CONJUGATION

Lanka, E., & Wilkins, B. M. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.001041 · Cited by 341 · see citing works

DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1

Cobb, J. A., Bjergbæk, L., Shimada, K., Frei, C., & Gasser, S. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg391 · Cited by 333 · see citing works

Replication of Eukaryotic Chromosomes: A Close-up of the Replication Fork

DePamphilis, M. L., & Wassarman, P. M. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.003211 · Cited by 329 · see citing works

The connection between transcription and genomic instability

Aguilera, A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.3.195 · Cited by 328 · see citing works

Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

Myung, K., Datta, A., & Kolodner, R. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00227-6 · Cited by 322 · see citing works

Multiple pathways process stalled replication forks

Michel, B., Grompone, G., Florès, M.-J., & Bidnenko, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401586101 · Cited by 322 · see citing works

Clustering of meiotic double-strand breaks on yeast chromosome III

Baudat, F., & Nicolas, A. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5213 · Cited by 320 · see citing works

Replication fork pausing and recombination or “gimme a break”Preprint

Rothstein, R. J., Michel, B., & Gangloff, S. (2000) · Genes & Development · doi:10.1101/gad.14.1.1 · Cited by 320 · see citing works

GENETICS OF BACTERIAL RIBOSOMES

Nomura, M., Morgan, E. A., & Jaskunas, S. R. (1977) · Annual Review of Genetics · doi:10.1146/annurev.ge.11.120177.001501 · Cited by 320 · see citing works

Replication fork reactivation downstream of a blocked nascent leading strand

Heller, R. C., & Marians, K. J. (2006) · Nature · doi:10.1038/nature04329 · Cited by 318 · see citing works

The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication

Gahn, T. A., & Schildkraut, C. L. (1989) · Cell · doi:10.1016/0092-8674(89)90433-9 · Cited by 315 · see citing works

Sticky DNA

Sakamoto, N., Chastain, P. D., Parniewski, P., Ohshima, K., Pandolfo, M., Griffith, J. D., & Wells, R. D. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80474-8 · Cited by 313 · see citing works

Molecular Basis of Genetic Instability of Triplet Repeats

Wells, R. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2875 · Cited by 303 · see citing works

Inhibitory Effects of Expanded GAA·TTC Triplet Repeats from Intron I of the Friedreich Ataxia Gene on Transcription and Replicationin Vivo

Ohshima, K., Montermini, L., Wells, R. D., & Pandolfo, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14588 · Cited by 302 · see citing works

Impairment of replication fork progression mediates RNA polII transcription‐associated recombination

Prado, F., & Aguilera, A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600602 · Cited by 294 · see citing works

Modulation of RNA polymerase by (p)ppGpp reveals a RecG-dependent mechanism for replication fork progression.

McGlynn, P., & Lloyd, R. (2000) · Cell · doi:10.1016/s0092-8674(00)80621-2 · Cited by 288 · see citing works

A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination

McMurry, M. T., & Krangel, M. S. (2000) · Science · doi:10.1126/science.287.5452.495 · Cited by 288 · see citing works

Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNAPreprint

Ivessa, A., Zhou, J., Schulz, V., Monson, E. K., & Zakian, V. A. (2002) · Genes & Development · doi:10.1101/gad.982902 · Cited by 284 · see citing works

Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication forkPreprint

Calzada, A., Hodgson, B., Kanemaki, M. T., Bueno, A., & Labib, K. P. M. (2005) · Genes & Development · doi:10.1101/gad.337205 · Cited by 280 · see citing works

Base Composition Skews, Replication Orientation, and Gene Orientation in 12 Prokaryote Genomes

McLean, M. J., Wolfe, K. H., & Devine, K. M. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006428 · Cited by 279 · see citing works

The arrest of replication forks in the rDNA of yeast occurs independently of transcription

Brewer, B. J., Lockshon, D., & Fangman, W. L. (1992) · Cell · doi:10.1016/0092-8674(92)90355-g · Cited by 274 · see citing works

The Saccharomyces Pif1p DNA Helicase and the Highly Related Rrm3p Have Opposite Effects on Replication Fork Progression in Ribosomal DNA

Ivessa, A., Zhou, J., & Zakian, V. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80683-2 · Cited by 274 · see citing works

Multistranded DNA structures

Gilbert, D. E., & Feigon, J. F. (1999) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(99)80041-4 · Cited by 273 · see citing works

Transcription-dependent recombination and the role of fork collision in yeast rDNAPreprint

Takeuchi, Y., Horiuchi, T., & Kobayashi, T. (2003) · Genes & Development · doi:10.1101/gad.1085403 · Cited by 272 · see citing works

Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I.

Drolet, M., Phoenix, P., Menzel, R., Massé, É., Liu, L. F., & Crouch, R. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3526 · Cited by 263 · see citing works

Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork Barrier

Lambert, S., Watson, A. T., Sheedy, D. M., Martin, B. R., & Carr, A. M. (2005) · Cell · doi:10.1016/j.cell.2005.03.022 · Cited by 261 · see citing works

Consequences of Replication Fork Movement Through Transcription Units in Vivo

French, S. L. (1992) · Science · doi:10.1126/science.1455232 · Cited by 259 · see citing works

Alternative Structures in Duplex DNA Formed within the Trinucleotide Repeats of the Myotonic Dystrophy and Fragile X Loci

Pearson, C. E., & Sinden, R. R. (1996) · Biochemistry · doi:10.1021/bi9601013 · Cited by 258 · see citing works

A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities

Kobayashi, T., & Horiuchi, T. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.d01-256.x · Cited by 252 · see citing works

Replication fork arrest and DNA recombination

Michel, B. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01560-7 · Cited by 247 · see citing works

Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region

Reaban, M. E., & Griffin, J. A. (1990) · Nature · doi:10.1038/348342a0 · Cited by 246 · see citing works

DNA structures, repeat expansions and human hereditary disorders

Mirkin, S. M. (2006) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2006.05.004 · Cited by 246 · see citing works

Initiation and termination of DNA replication in human rRNA genes.

Little, R. D., Platt, T. H. K., & Schildkraut, C. L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6600 · Cited by 243 · see citing works

CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro

Usdin, K., & Woodford, K. J. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.20.4202 · Cited by 241 · see citing works

Positive Torsional Strain Causes the Formation of a Four-way Junction at Replication Forks

Postow, L., Ullsperger, C., Keller, R. W., Bustamante, C., Vologodskii, A. V., & Cozzarelli, N. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006736200 · Cited by 237 · see citing works

WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci

Bozhenok, L., Wade, P. A., & Varga‐Weisz, P. (2002) · The EMBO Journal · doi:10.1093/emboj/21.9.2231 · Cited by 236 · see citing works

Preferential DNA secondary structure mutagenesis in the lagging strand of replication in E. coli

Trinh, T. Q., & Sinden, R. R. (1991) · Nature · doi:10.1038/352544a0 · Cited by 235 · see citing works

Association of fragile X syndrome with delayed replication of the FMR1 gene

Hansen, R. S., Canfield, T. K., Lamb, M. M., Gartler, S. M., & Laird, C. D. (1993) · Cell · doi:10.1016/0092-8674(93)90365-w · Cited by 234 · see citing works

The Bacterial Chromosome

Drlica, K., & Riley, M. (1990) · Cited by 230 · see citing works

Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications.

Chen, X., Mariappan, S. V. S., Catasti, P., Ratliff, R. L., Moyzis, R. K., Laayoun, A., Smith, S. S., Bradbury, E. M., & Gupta, G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5199 · Cited by 227 · see citing works

Head-On Collision Between a DNA Replication Apparatus and RNA Polymerase Transcription Complex

Liu, B., & Alberts, B. (1995) · Science · doi:10.1126/science.7855590 · Cited by 225 · see citing works

Slippery DNA and diseases

Kunkel, T. A. (1993) · Nature · doi:10.1038/365207a0 · Cited by 222 · see citing works

DNA secondary structure: A common and causative factor for expansion in human disease

McMurray, C. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1823 · Cited by 219 · see citing works

Stability of a CTG/CAG Trinucleotide Repeat in Yeast Is Dependent on Its Orientation in the Genome

Freudenreich, C. H., Stavenhagen, J. B., & Zakian, V. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2090 · Cited by 219 · see citing works

Role of PriA in Replication Fork Reactivation in Escherichia coli

Sandler, S. J., & Marians, K. J. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.1.9-13.2000 · Cited by 213 · see citing works

Essentiality, not expressiveness, drives gene-strand bias in bacteria

Rocha, E. P. C., & Danchin, A. (2003) · Nature Genetics · doi:10.1038/ng1209 · Cited by 211 · see citing works

RecA-Dependent Recovery of Arrested DNA Replication Forks

Courcelle, J., & Hanawalt, P. C. (2003) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.142616 · Cited by 210 · see citing works

Replication Stalling at Friedreich's Ataxia (GAA)n Repeats In Vivo

Krasilnikova, M. M., & Mirkin, S. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2286-2295.2004 · Cited by 207 · see citing works

Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells

Cleary, J., Nichol, K., Wang, Y.-H., & Pearson, C. E. (2002) · Nature Genetics · doi:10.1038/ng870 · Cited by 206 · see citing works

The DNA damage response: sensing and signaling

McGowan, C. H., & Russell, P. R. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.005 · Cited by 202 · see citing works

Repeat expansion — all in flap?

Gordenin, D. A., Kunkel, T. A., & Resnick, M. A. (1997) · Nature Genetics · doi:10.1038/ng0697-116 · Cited by 201 · see citing works

Mechanisms of Transcription-Replication Collisions in Bacteria

Mirkin, E. V., & Mirkin, S. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.888-895.2005 · Cited by 198 · see citing works

Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA

Pearson, C. E., & Sinden, R. R. (1998) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(98)80065-1 · Cited by 196 · see citing works

A Sliding-Clamp Toolbelt Binds High- and Low-Fidelity DNA Polymerases Simultaneously

Indiani, C., McInerney, P., Georgescu, R. E., Goodman, M. F., & O’Donnell, M. E. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.011 · Cited by 194 · see citing works

Sequence-Directed DNA Translocation by Purified FtsK

Pease, P., Levy, O., Cost, G., Gore, J., Ptacin, J. L., Sherratt, D., Bustamante, C., & Cozzarelli, N. (2005) · Science · doi:10.1126/science.1104885 · Cited by 193 · see citing works

The Structure of Supercoiled Intermediates in DNA Replication

Peter, B. J., Ullsperger, C., Hiasa, H., Marians, K. J., & Cozzarelli, N. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81740-7 · Cited by 184 · see citing works

Pausing of DNA Synthesis in Vitro at Specific Loci in CTG and CGG Triplet Repeats from Human Hereditary Disease Genes

Kang, S., Ohshima, K., Shimizu, M., Amirhaeri, S., & Wells, R. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27014 · Cited by 184 · see citing works

Human Chromosomal Fragile Site FRA16B Is an Amplified AT-Rich Minisatellite Repeat

Yu, S., Mangelsdorf, M., Hewett, D. R., Hobson, L., Baker, E. G., Eyre, H. J., Lapsys, N. M., Paslier, D. L., Doggett, N. A., Sutherland, G. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81875-9 · Cited by 182 · see citing works

Expansions of CAG Repeat Tracts are Frequent in a Yeast Mutant Defective in Okazaki Fragment Maturation

Schweitzer, J. K., & Livingston, D. M. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.1.69 · Cited by 180 · see citing works

Hypernegative supercoiling of the DNA template during transcription elongation in vitro.

Drolet, M., Bi, X., & Liu, L. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42136-3 · Cited by 179 · see citing works

Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae

Miret, J. J., Pessoa-Brandão, L., & Lahue, R. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12438 · Cited by 178 · see citing works

Inhibition of FEN-1 Processing by DNA Secondary Structure at Trinucleotide Repeats

Spiro, C., Pelletier, R., Rolfsmeier, M. L., Dixon, M. J., Lahue, R. S., Gupta, G., Park, M. S., Chen, X., Mariappan, S. V. S., & McMurray, C. T. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80236-1 · Cited by 177 · see citing works

Fragile sites still breaking

Sutherland, G. R., Baker, E., & Richards, R. I. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01628-x · Cited by 174 · see citing works

Multiple Genetic Pathways for Restarting DNA Replication Forks in Escherichia coli K-12

Sandler, S. J. (2000) · Genetics · doi:10.1093/genetics/155.2.487 · Cited by 172 · see citing works

Occurrence of potential cruciform and H-DNA forming sequences in genomic DNA

Schroth, G. P., & Ho, P. S. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.11.1977 · Cited by 172 · see citing works

GAA Instability in Friedreich's Ataxia Shares a Common, DNA-Directed and Intraallelic Mechanism with Other Trinucleotide Diseases

Gacy, A. M., Goellner, G. M., Spiro, C., Chen, X., Gupta, G., Bradbury, E. M., Dyer, R. B., Mikesell, M. J., Yao, J. Z., Johnson, A. J., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80058-1 · Cited by 170 · see citing works

Identification of Cell Cycle-regulated Genes in Fission Yeast

Peng, X., Karuturi, R. K. M., Miller, L. D., Lin, K., Jia, Y., Akalın, P., Wang, L., Wong, L., Liu, E. T., Balasubramanian, M. K., et al. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0299 · Cited by 170 · see citing works

The Replication Fork Barrier Site Forms a Unique Structure with Fob1p and Inhibits the Replication Fork

Kobayashi, T. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9178-9188.2003 · Cited by 169 · see citing works

Replication and Expansion of Trinucleotide Repeats in Yeast

Pelletier, R., Krasilnikova, M. M., Samadashwily, G. M., Lahue, R. S., & Mirkin, S. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1349-1357.2003 · Cited by 164 · see citing works

Visualization of DNA Replication on Individual Epstein-Barr Virus Episomes

Norio, P., & Schildkraut, C. L. (2001) · Science · doi:10.1126/science.1064603 · Cited by 163 · see citing works

Swi1 Prevents Replication Fork Collapse and Controls Checkpoint Kinase Cds1

Noguchi, E., Noguchi, C., Du, L., & Russell, P. R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7861-7874.2003 · Cited by 163 · see citing works

Anatomy and Dynamics of DNA Replication Fork Movement in Yeast Telomeric Regions

Makovets, S., Herskowitz, I., & Blackburn, E. H. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.9.4019-4031.2004 · Cited by 162 · see citing works

The replication terminator protein of E. coli is a DNA sequence-specific contra-helicase

Khatri, G. S., MacAllister, T. W., Sista, P. R., & Bastia, D. (1989) · Cell · doi:10.1016/0092-8674(89)90012-3 · Cited by 160 · see citing works

swi1 and swi3 Perform Imprinting, Pausing, and Termination of DNA Replication in S. pombe

Dalgaard, J. Z., & Klar, A. J. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00063-5 · Cited by 157 · see citing works

Sequence non‐specific double‐strand breaks and interhomolog interactions prior to double‐strand break formation at a meiotic recombination hot spot in yeast.

Xu, L., & Kleckner, N. E. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00194.x · Cited by 156 · see citing works

Replication Termination inEscherichia coli: Structure and Antihelicase Activity of the Tus-TerComplex

Neylon, C., Kralicek, A. V., Hill, T., & Dixon, N. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.3.501-526.2005 · Cited by 151 · see citing works

Escherichia coli replication termination protein impedes the action of helicases.

Lee, E. H., Kornberg, A., Hidaka, M., Kobayashi, T., & Horiuchi, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9104 · Cited by 150 · see citing works

The molecular basis of common and rare fragile sites

Schwartz, M., Zlotorynski, E., & Kerem, B. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.07.039 · Cited by 149 · see citing works

Mechanisms of common fragile site instability

Glover, T. W., Arlt, M. F., Casper, A. M., & Durkin, S. G. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi265 · Cited by 146 · see citing works

Formation of DNA triplexes accounts for arrests of DNA synthesis at d(TC)n and d(GA)n tracts.

Baran, N., Lapidot, A., & Manor, H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.2.507 · Cited by 144 · see citing works

Orientation of DNA replication establishes mating-type switching pattern in S. pombe

Dalgaard, J. Z., & Klar, A. J. S. (1999) · Nature · doi:10.1038/22139 · Cited by 142 · see citing works

Implications of FRA16A Structure for the Mechanism of Chromosomal Fragile Site Genesis

Nancarrow, J. K., Kremer, E. J., Holman, K., Eyre, H. J., Doggett, N. A., Paslier, D. L., Callen, D. F., Sutherland, G. R., & Richards, R. I. (1994) · Science · doi:10.1126/science.8009225 · Cited by 139 · see citing works

Replication Forks Pause at Yeast Centromeres

Greenfeder, S. A., & Newlon, C. S. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.9.4056-4066.1992 · Cited by 138 · see citing works

Termination of Mammalian rDNA Replication: Polar Arrest of Replication Fork Movement by Transcription Termination Factor TTF-I

Gerber, J., Gögel, E., Berger, C., Wallisch, M., Müller, F., Grummt, I., & Grummt, F. (1997) · Cell · doi:10.1016/s0092-8674(00)80515-2 · Cited by 137 · see citing works

Controlling the efficiency of excision repair

Hanawalt, P. C. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00071-9 · Cited by 137 · see citing works

Characteristic enrichment of DNA repeats in different genomes

Cox, R., & Mirkin, S. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5237 · Cited by 137 · see citing works

Transcription induces the formation of a stable RNA.DNA hybrid in the immunoglobulin alpha switch region.

Reaban, M. E., Lebowitz, J., & Griffin, J. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31881-1 · Cited by 136 · see citing works

Uncoupling of Unwinding from DNA Synthesis Implies Regulation of MCM Helicase by Tof1/Mrc1/Csm3 Checkpoint Complex

Nedelcheva, M. N., Roguev, A., Dolapchiev, L. B., Shevchenko, A., Taskov, H. B., Shevchenko, A., Stewart, A. F., & Stoynov, S. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.01.041 · Cited by 135 · see citing works

Identification of the DNA sequence from the E. coli terminus region that halts replication forks

Hill, T., Pelletier, A. J., Tecklenburg, M., & Kuempel, P. L. (1988) · Cell · doi:10.1016/0092-8674(88)90032-3 · Cited by 133 · see citing works

The intrinsically unstable life of DNA triplet repeats associated with human hereditary disorders

Bowater, R. P., & Wells, R. D. (2000) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(00)66029-4 · Cited by 131 · see citing works

Organization of supercoil domains and their reorganization by transcription

Deng, S. H., Stein, R. A., & Higgins, N. P. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04796.x · Cited by 131 · see citing works

Replisome Architecture and Dynamics in Escherichia coli

O’Donnell, M. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r500028200 · Cited by 131 · see citing works

Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases

Petruska, J. A. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.11.1992 · Cited by 130 · see citing works

The terminus region of the Escherichia coli chromosome contains two separate loci that exhibit polar inhibition of replication.

Hill, T., Henson, J. M., & Kuempel, P. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.7.1754 · Cited by 129 · see citing works

Specific sequences in native DNA that arrest synthesis by DNA polymerase alpha.

Weaver, D. T., & DePamphilis, M. L. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68148-2 · Cited by 126 · see citing works

Tof1p Regulates DNA Damage Responses During S Phase in Saccharomyces cerevisiae

Foss, E. J. (2001) · Genetics · doi:10.1093/genetics/157.2.567 · Cited by 126 · see citing works

Checkpoint responses to replication fork barriers

Lambert, S., & Carr, A. M. (2004) · Biochimie · doi:10.1016/j.biochi.2004.10.020 · Cited by 125 · see citing works

A Molecular Mousetrap Determines Polarity of Termination of DNA Replication in E. coli

Mulcair, M. D., Schaeffer, P. M., Oakley, A. J., Cross, H. F., Neylon, C., Hill, T., & Dixon, N. E. (2006) · Cell · doi:10.1016/j.cell.2006.04.040 · Cited by 125 · see citing works

Transcription by RNA polymerase I stimulates mitotic recombination in Saccharomyces cerevisiae.

Stewart, S. E., & Roeder, G. S. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.8.3464 · Cited by 125 · see citing works

Escherichia coli Tus protein acts to arrest the progression of DNA replication forks in vitro.

Hill, T., & Marians, K. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2481 · Cited by 124 · see citing works

Organization of Replication of Ribosomal DNA in Saccharomyces cerevisiae

Linskens, M. H. K., & Huberman, J. A. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.11.4927-4935.1988 · Cited by 119 · see citing works

A DNA replication-arrest site RTS1 regulates imprinting by determining the direction of replication at mat1 in S. pombePreprint

Dalgaard, J. Z., & Klar, A. J. S. (2001) · Genes & Development · doi:10.1101/gad.200801 · Cited by 118 · see citing works

Tracking of controlled Escherichia coli replication fork stalling and restart at repressor‐bound DNA in vivo

Possoz, C., Filipe, S. R., Grainge, I., & Sherratt, D. J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601155 · Cited by 113 · see citing works

Replication fork collapse at replication terminator sequences

Bidnenko, V., Ehrlich, S., & Michel, B. (2002) · EMBO Journal · doi:10.1093/emboj/cdf369 · Cited by 112 · see citing works

tus, the trans-acting gene required for termination of DNA replication in Escherichia coli, encodes a DNA-binding protein.

Hill, T., Tecklenburg, M., Pelletier, A. J., & Kuempel, P. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1593 · Cited by 112 · see citing works

The DNA replication fork can pass RNA polymerase without displacing the nascent transcript

Liu, B., Wong, M. L., Tinker-Kulberg, R. L., Geiduschek, E. P., & Alberts, B. (1993) · Nature · doi:10.1038/366033a0 · Cited by 107 · see citing works

Inhibition of Flap Endonuclease 1 by Flap Secondary Structure and Relevance to Repeat Sequence Expansion

Henricksen, L. A., Tom, S., Liu, Y., & Bambara, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909635199 · Cited by 107 · see citing works

A consensus sequence of three DNA replication terminus sites on the E. coli chromosome is highly homologous to the terR sites of the R6K plasmid

Hidaka, M., Akiyama, M., & Horiuchi, T. (1988) · Cell · doi:10.1016/0092-8674(88)90033-5 · Cited by 107 · see citing works

Escherichia coli RecG and RecA proteins in R‐loop formation.

Hong, X., Cadwell, G. W., & Kogoma, T. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07233.x · Cited by 106 · see citing works

Structure of a replication-terminator protein complexed with DNA

Kamada, K., Horiuchi, T., Ohsumi, K., Shimamoto, N., & Morikawa, K. (1996) · Nature · doi:10.1038/383598a0 · Cited by 106 · see citing works

DNA repeat expansions and human disease

Usdin, K., & Grabczyk, E. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000734 · Cited by 106 · see citing works

swi1 - and swi3 -dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe

Krings, G., & Bastia, D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406037101 · Cited by 106 · see citing works

A nonanucleotide sequence involved in promotion of ribosomal RNA synthesis and RNA priming of DNA replication on yeast mitochondria

Osinga, K. A., HAAN, M. D., Christianson, T., & Tabak, H. F. (1982) · Nucleic Acids Research · doi:10.1093/nar/10.24.7993 · Cited by 103 · see citing works

The stringent response blocks DNA replication outside the ori region in Bacillus subtilis and at the origin in Escherichia coli

Lévine, A., Vannier, F., Dehbi, M., Henckes, G., & Séror, S. J. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90657-r · Cited by 103 · see citing works

Ten Commandments: Lessons from the Enzymology of DNA Replication

Kornberg, A. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.13.3613-3618.2000 · Cited by 102 · see citing works

rDNA Enhancer Affects Replication Initiation and Mitotic Recombination

Burkhalter, M. D., & Sogo, J. M. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.024 · Cited by 101 · see citing works

A novel K(+)-dependent DNA synthesis arrest site in a commonly occurring sequence motif in eukaryotes.

Woodford, K., Howell, R., & Usdin, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47121-9 · Cited by 100 · see citing works

Mechanisms and consequences of replication fork arrest

Hyrien, O. (2000) · Biochimie · doi:10.1016/s0300-9084(00)00344-8 · Cited by 97 · see citing works

Unpaired Structures in SCA10 (ATTCT)n·(AGAAT)n Repeats

Potaman, V. N., Bissler, J. J., Hashem, V. I., Oussatcheva, E. A., Lu, L., Shlyakhtenko, L. S., Lyubchenko, Y. L., Matsuura, T., Ashizawa, T., Leffak, M., et al. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00037-8 · Cited by 96 · see citing works

Intramolecular DNA triplexes: unusual sequence requirements and influence on DNA polymerization.

Dayn, A., Samadashwily, G. M., & Mirkin, S. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11406 · Cited by 96 · see citing works

Stability of the Human Fragile X (CGG) n Triplet Repeat Array in Saccharomyces cerevisiae Deficient in Aspects of DNA Metabolism

White, P. J., Borts, R. H., & Hirst, M. C. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5675 · Cited by 95 · see citing works

Recombinational rescue of the stalled DNA replication fork: a model based on analysis of an Escherichia coli strain with a chromosome region difficult to replicate

Horiuchi, T., & Fujimura, Y. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.3.783-791.1995 · Cited by 95 · see citing works

The RecG Branch Migration Protein ofEscherichia coliDissociates R-loops

Vincent, S. D., Mahdi, A. A., & Lloyd, R. G. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0671 · Cited by 94 · see citing works

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works

R Loops: From Transcription Byproducts to Threats to Genome Stability

Aguilera, A., & García‐Muse, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.009 · Cited by 1,029 · see citing works

Maintaining genome stability at the replication fork

Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786 · see citing works

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA RepairPreprint

Mehta, A., & Haber, J. E. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016428 · Cited by 727 · see citing works

Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

Hamperl, S., Bocek, M. J., Saldivar, J. C., Swigut, T., & Cimprich, K. A. (2017) · Cell · doi:10.1016/j.cell.2017.07.043 · Cited by 639 · see citing works

ATM and ATR as therapeutic targets in cancer

Weber, A. M., & Ryan, A. J. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.001 · Cited by 644 · see citing works

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

Helmrich, A., Ballarino, M., & Tora, L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.10.013 · Cited by 576 · see citing works

Comparative Genomics and Molecular Dynamics of DNA Repeats in Eukaryotes

Richard, G., Kerrest, A., & Dujon, B. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00011-08 · Cited by 549 · see citing works

Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin

Cannan, W. J., & Pederson, D. S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25048 · Cited by 499 · see citing works

Mechanisms of trinucleotide repeat instability during human development

McMurray, C. T. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2828 · Cited by 496 · see citing works

R-loop-mediated genomic instability is caused by impairment of replication fork progressionPreprint

Gan, W., Guan, Z., Liu, J., Gui, T., Shen, K., Manley, J. L., & Xialu Li, C. (2011) · Genes & Development · doi:10.1101/gad.17010011 · Cited by 459 · see citing works

Hallmarks of DNA replication stress

Saxena, S., & Zou, L. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.05.004 · Cited by 442 · see citing works

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

Barlow, J. H., Faryabi, R. B., Callén, E., Wong, N., Malhowski, A. J., Chen, H. T., Gutierrez-Cruz, G., Sun, H., McKinnon, P. J., Wright, G. W., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.006 · Cited by 433 · see citing works

Human mutation rate associated with DNA replication timing

Stamatoyannopoulos, J. A., Adzhubei, I. A., Thurman, R. E., Kryukov, G. V., Mirkin, S. M., & Sunyaev, S. R. (2009) · Nature Genetics · doi:10.1038/ng.363 · Cited by 412 · see citing works

Non-B DNA structure-induced genetic instability and evolution

Zhao, J., Bacolla, A., Wang, G., & Vásquez, K. M. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0131-2 · Cited by 405 · see citing works

Increased global transcription activity as a mechanism of replication stress in cancer

Kotsantis, P., Silva, L. M., Irmscher, S., Jones, R. M., Folkes, L. K., Gromak, N., & Petermann, E. (2016) · Nature Communications · doi:10.1038/ncomms13087 · Cited by 333 · see citing works

G‐quadruplex‐induced instability during leading‐strand replication

Lopes, J., Piazza, A., Bermejo, R., Kriegsman, B. A., Colosio, A., Teulade‐Fichou, M., Foiani, M., & Nicolas, A. G. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.316 · Cited by 330 · see citing works

Linking RNA Polymerase Backtracking to Genome Instability in E. coli

Dutta, D., Shatalin, K. Y., Epshtein, V., Gottesman, M. E., & Nudler, E. (2011) · Cell · doi:10.1016/j.cell.2011.07.034 · Cited by 322 · see citing works

Epigenetic Instability due to Defective Replication of Structured DNA

Sarkies, P., Reams, C., Simpson, L. J., & Sale, J. E. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.009 · Cited by 302 · see citing works

PCNA on the crossroad of cancer

Stoimenov, I., & Helleday, T. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370605 · Cited by 292 · see citing works

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae

Azvolinsky, A., Giresi, P. G., Lieb, J. D., & Zakian, V. A. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.05.022 · Cited by 285 · see citing works

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

Técher, H., Koundrioukoff, S., Nicolas, A. G., & Debatisse, M. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.46 · Cited by 271 · see citing works

A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair

Babu, M., Beloglazova, N. G., Flick, R., Graham, C., Skarina, T., Nocek, B. P., Gagarinova, A. G., Pogoutse, O., Brown, G., Binkowski, A., et al. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07465.x · Cited by 260 · see citing works

The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo

Boubakri, H., de Septenville, A. L., Viguera, E., & Michel, B. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.308 · Cited by 253 · see citing works

The Plastid Genomes of Flowering Plants

Ruhlman, T. A., & Jansen, R. K. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-995-6_1 · Cited by 253 · see citing works

Fragile sites in cancer: more than meets the eye

Glover, T. W., Wilson, T. E., & Arlt, M. F. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.52 · Cited by 234 · see citing works

Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes

Alzu, A., Bermejo, R., Begnis, M., Lucca, C., Piccini, D., Carotenuto, W., Saponaro, M., Brambati, A., Cocito, A., Foiani, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.041 · Cited by 231 · see citing works

Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective

Chowdhury, D. (2013) · Physics Reports · doi:10.1016/j.physrep.2013.03.005 · Cited by 218 · see citing works

Whirly proteins maintain plastid genome stability in Arabidopsis

Maréchal, A., Parent, J., Véronneau-Lafortune, F., Joyeux, A., Lang, B. F., & Brisson, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901710106 · Cited by 220 · see citing works

Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomesPreprint

Chen, C.-L., Rappailles, A., Duquenne, L., Huvet, M., Guilbaud, G., Farinelli, L., Audit, B., d'Aubenton-Carafa, Y., Arneodo, A., Hyrien, O., et al. (2010) · Genome Research · doi:10.1101/gr.098947.109 · Cited by 205 · see citing works

Nuclear Deformation Causes DNA Damage by Increasing Replication Stress

Shah, P., Hobson, C. M., Cheng, S., Colville, M. J., Paszek, M. J., Superfine, R., & Lammerding, J. (2020) · Current Biology · doi:10.1016/j.cub.2020.11.037 · Cited by 212 · see citing works

Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse

Tubbs, A., Sridharan, S., van Wietmarschen, N., Maman, Y., Callén, E., Stanlie, A., Wu, W., Wu, X., Day, A., Wong, N., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.011 · Cited by 196 · see citing works

Co-Orientation of Replication and Transcription Preserves Genome Integrity

Srivatsan, A., Tehranchi, A. K., MacAlpine, D. M., & Wang, J. D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000810 · Cited by 194 · see citing works

The replisome uses mRNA as a primer after colliding with RNA polymerase

Pomerantz, R. T., & O’Donnell, M. E. (2008) · Nature · doi:10.1038/nature07527 · Cited by 190 · see citing works

Co-directional replication–transcription conflicts lead to replication restart

Merrikh, H., Machón, C., Grainger, W. H., Grossman, A. D., & Soultanas, P. (2011) · Nature · doi:10.1038/nature09758 · Cited by 187 · see citing works

Plasmid DNA vaccine vector design: Impact on efficacy, safety and upstream production

Williams, J. A., Carnes, A. E., & Hodgson, C. P. (2009) · Biotechnology Advances · doi:10.1016/j.biotechadv.2009.02.003 · Cited by 182 · see citing works

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

Carr, A. M., & Lambert, S. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.04.023 · Cited by 179 · see citing works

FANCD2 Facilitates Replication through Common Fragile Sites

Madireddy, A., Kosiyatrakul, S. T., Boisvert, R. A., Herrera‐Moyano, E., García-Rubio, M. L., Gerhardt, J., Vuono, E. A., Owen, N. M., Yan, Z., Olson, S. B., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.017 · Cited by 163 · see citing works

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

Hu, J., Sun, L., Shen, F., Chen, Y., Yu, H., Liu, Y., Zhang, M., Hu, Y., Wang, Q., Xu, W. F., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.030 · Cited by 164 · see citing works

Rep Provides a Second Motor at the Replisome to Promote Duplication of Protein-Bound DNA

Guy, C. P., Atkinson, J., Gupta, M. K., Mahdi, A. A., Gwynn, E. J., Rudolph, C. J., Moon, P. B., van Knippenberg, I. C., Cadman, C. J., Dillingham, M. S., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.11.009 · Cited by 163 · see citing works

R-loop generation during transcription: Formation, processing and cellular outcomes

Belotserkovskii, B. P., Tornaletti, S., D’Souza, A. D., & Hanawalt, P. C. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.08.009 · Cited by 155 · see citing works

Mechanisms and implications of transcription blockage by guanine-rich DNA sequences

Belotserkovskii, B. P., Liu, R. Y., Tornaletti, S., Krasilnikova, M. M., Mirkin, S. M., & Hanawalt, P. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007580107 · Cited by 155 · see citing works

Clusters of Nucleotide Substitutions and Insertion/Deletion Mutations Are Associated with Repeat Sequences

McDonald, M. J., Wang, W.-C., Huang, H., & Leu, J. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000622 · Cited by 150 · see citing works

Replication-dependent instability at (CTG)•(CAG) repeat hairpins in human cells

Liu, G., Chen, X., Bissler, J. J., Sinden, R. R., & Leffak, M. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.416 · Cited by 149 · see citing works

The Transcription Factor DksA Prevents Conflicts between DNA Replication and Transcription Machinery

Tehranchi, A. K., Blankschien, M. D., Zhang, Y., Halliday, J. A., Srivatsan, A., Peng, J., Herman, C., & Wang, J. D. (2010) · Cell · doi:10.1016/j.cell.2010.03.036 · Cited by 148 · see citing works

The Interplay between G-quadruplex and Transcription

Kim, N. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867325666171229132619 · Cited by 146 · see citing works

Accelerated gene evolution through replication–transcription conflicts

Paul, S., Million‐Weaver, S., Chattopadhyay, S., Sokurenko, E. V., & Merrikh, H. (2013) · Nature · doi:10.1038/nature11989 · Cited by 138 · see citing works

Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest

Coluzzi, E., Leone, S., & Sgura, A. (2019) · Cells · doi:10.3390/cells8010019 · Cited by 138 · see citing works

Mechanisms of structural chromosomal rearrangement formation

Burssed, B., Zamariolli, M., Bellucco, F. T. D. S., & Melaragno, M. I. (2022) · Molecular Cytogenetics · doi:10.1186/s13039-022-00600-6 · Cited by 133 · see citing works

DNA triplet repeat expansion and mismatch repair

Iyer, R. R., Pluciennik, A., Napierala, M., & Wells, R. D. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034010 · Cited by 130 · see citing works

Determinants of G quadruplex‐induced epigenetic instability in REV1‐deficient cells

Schiavone, D., Guilbaud, G., Murat, P., Papadopoulou, C., Sarkies, P., Prioleau, M., Balasubramanian, S., & Sale, J. E. (2014) · The EMBO Journal · doi:10.15252/embj.201488398 · Cited by 128 · see citing works

Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response

Ragu, S., Matos-Rodrigues, G. E., & López, B. S. (2020) · Genes · doi:10.3390/genes11040409 · Cited by 123 · see citing works

Double-strand break repair in bacteria: a view fromBacillus subtilis

Ayora, S., Carrasco, B., Cárdenas, P. P., César, C. E., Cañas, C., Yadav, T., Marchisone, C., & Alonso, J. C. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00272.x · Cited by 121 · see citing works

DNA Damage Response and Immune Defense

Nastasi, C., Mannarino, L., & D’Incalci, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207504 · Cited by 119 · see citing works

Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A

Musich, P. R., & Zou, Y. (2009) · Aging · doi:10.18632/aging.100012 · Cited by 117 · see citing works

Transcription termination maintains chromosome integrity

Washburn, R. S., & Gottesman, M. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009564108 · Cited by 117 · see citing works

Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A

Liu, Y., Wang, Y., Rusinol, A. E., Sinensky, M. S., Liu, J., Shell, S. M., & Zou, Y. (2008) · The FASEB Journal · doi:10.1096/fj.07-8598com · Cited by 115 · see citing works

Mechanisms of rDNA Copy Number Maintenance

Nelson, J. O., Watase, G. J., Warsinger-Pepe, N., & Yamashita, Y. M. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.07.006 · Cited by 115 · see citing works

Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome

Guiblet, W. M., Cremona, M. A., Harris, R. S., Chen, D., Eckert, K. A., Chiaromonte, F., Huang, Y.-F., & Makova, K. D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa1269 · Cited by 115 · see citing works

Replication Fork Reversal after Replication–Transcription Collision

de Septenville, A. L., Duigou, S., Boubakri, H., & Michel, B. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002622 · Cited by 113 · see citing works

Proliferating Cell Nuclear Antigen (PCNA) Regulates Primordial Follicle Assembly by Promoting Apoptosis of Oocytes in Fetal and Neonatal Mouse Ovaries

Xu, B., Hua, J., Zhang, Y., Jiang, X., Zhang, H., Ma, T., Wei, Z., Sun, R., Shen, W. D., Sha, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016046 · Cited by 110 · see citing works

Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases

Zheng, L., Meng, Y., Campbell, J. L., & Shen, B. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1101 · Cited by 108 · see citing works

At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences

Aksenova, A. Y., & Mirkin, S. M. (2019) · Genes · doi:10.3390/genes10020118 · Cited by 110 · see citing works

Identifying G-Quadruplex-DNA-Disrupting Small Molecules

Mitteaux, J., Lejault, P., Wojciechowski, F., Joubert, A., Boudon, J., Desbois, N., Gros, C. P., Hudson, R. H. E., Boulé, J.-B., Granzhan, A., et al. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c04426 · Cited by 107 · see citing works

DNA Sequences That Interfere with Transcription: Implications for Genome Function and Stability

Belotserkovskii, B. P., Mirkin, S. M., & Hanawalt, P. C. (2013) · Chemical Reviews · doi:10.1021/cr400078y · Cited by 103 · see citing works

Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy

Aziz, K., Nowsheen, S., Pantelias, G. E., Iliakis, G. E., Gorgoulis, V. G., & Georgakilas, A. G. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.11.010 · Cited by 104 · see citing works

R‐loop formation during S phase is restricted by PrimPol‐mediated repriming

Šviković, S., Crisp, A., Tan‐Wong, S. M., Guilliam, T. A., Doherty, A. J., Proudfoot, N. J., Guilbaud, G., & Sale, J. E. (2018) · The EMBO Journal · doi:10.15252/embj.201899793 · Cited by 101 · see citing works

Impediments to replication fork movement: stabilisation, reactivation and genome instability

Lambert, S., & Carr, A. M. (2013) · Chromosoma · doi:10.1007/s00412-013-0398-9 · Cited by 98 · see citing works

Structure and repair of replication-coupled DNA breaks

Pavani, R., Tripathi, V., Vrtis, K. B., Zong, D., Chari, R., Callén, E., Pankajam, A. V., Zhen, G., Matos-Rodrigues, G. E., Yang, J., et al. (2024) · Science · doi:10.1126/science.ado3867 · Cited by 98 · see citing works

Replication fork instability and the consequences of fork collisions from rereplicationPreprint

Alexander, J. L., & Orr‐Weaver, T. L. (2016) · Genes & Development · doi:10.1101/gad.288142.116 · Cited by 92 · see citing works

Local and global functions of Timeless and Tipin in replication fork protection

Leman, A. R., & Noguchi, E. (2012) · Cell Cycle · doi:10.4161/cc.21989 · Cited by 92 · see citing works

Overcoming natural replication barriers: differential helicase requirements

Anand, R., Shah, K., Niu, H., Sung, P., Mirkin, S. M., & Freudenreich, C. H. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr836 · Cited by 93 · see citing works

The conflict between DNA replication and transcription

McGlynn, P., Savery, N. J., & Dillingham, M. S. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08102.x · Cited by 92 · see citing works

The role of fork stalling and DNA structures in causing chromosome fragility

Kaushal, S., & Freudenreich, C. H. (2018) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22721 · Cited by 88 · see citing works

Recovery of Arrested Replication Forks by Homologous Recombination Is Error-Prone

Iraqui, I., Chekkal, Y., Jmari, N., Pietrobon, V., Fréon, K., Costes, A., & Lambert, S. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002976 · Cited by 89 · see citing works

Stalled replication forks within heterochromatin require ATRX for protection

Huh, M. S., Ivanochko, D., Hashem, L. E., Curtin, M., Delorme, M., Goodall, E. C., Yan, K., & Picketts, D. J. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.121 · Cited by 89 · see citing works

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

Madireddy, A., Purushothaman, P., Loosbroock, C., Robertson, E. S., Schildkraut, C. L., & Verma, S. C. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw038 · Cited by 88 · see citing works

Human telomeres replicate using chromosome-specific, rather than universal, replication programs

Drosopoulos, W. C., Kosiyatrakul, S. T., Yan, Z., Calderano, S. G., & Schildkraut, C. L. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201112083 · Cited by 83 · see citing works

Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcriptionPreprint

Hoffman, E. A., McCulley, A., Haarer, B. K., Arnak, R., & Feng, W. (2015) · Genome Research · doi:10.1101/gr.180497.114 · Cited by 86 · see citing works

Is RecG a general guardian of the bacterial genome?

Rudolph, C. J., Upton, A. L., Briggs, G. S., & Lloyd, R. G. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.014 · Cited by 83 · see citing works

Cooperation of RAD51 and RAD54 in regression of a model replication fork

Bugreev, D. V., Rossi, M. J., & Mazin, A. V. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1139 · Cited by 85 · see citing works

Transcription leads to pervasive replisome instability in bacteria

Mangiameli, S. M., Merrikh, C. N., Wiggins, P. A., & Merrikh, H. (2017) · eLife · doi:10.7554/elife.19848 · Cited by 82 · see citing works

Whither the replisome: Emerging perspectives on the dynamic nature of the DNA replication machinery

Langston, L. D., Indiani, C., & O’Donnell, M. E. (2009) · Cell Cycle · doi:10.4161/cc.8.17.9390 · Cited by 81 · see citing works

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

Shah, S. N., Opresko, P. L., Meng, X., Lee, M., & Eckert, K. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1131 · Cited by 81 · see citing works

Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes

Osmundson, J., Kumar, J., Yeung, R., & Smith, D. J. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3342 · Cited by 77 · see citing works

Rad3ATR Decorates Critical Chromosomal Domains with γH2A to Protect Genome Integrity during S-Phase in Fission Yeast

Rozenzhak, S., Mejía-Ramírez, E., Williams, J. S., Schaffer, L., Hammond, J. A., Head, S. R., & Russell, P. R. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001032 · Cited by 75 · see citing works

Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error ratePreprint

Guiblet, W. M., Cremona, M. A., Čechová, M., Harris, R. S., Kejnovská, I., Kejnovský, E., Eckert, K. A., Chiaromonte, F., & Makova, K. D. (2018) · Genome Research · doi:10.1101/gr.241257.118 · Cited by 76 · see citing works

Transcription–translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits

Fan, H., Conn, A. B., Williams, P. B., Diggs, S., Hahm, J., Gamper, H., Hou, Y., O’Leary, S. E., Wang, Y., & Blaha, G. M. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx719 · Cited by 75 · see citing works

Timing and spacing of ubiquitin‐dependent DNA damage bypass

Ulrich, H. D. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.028 · Cited by 73 · see citing works

Chromosomal rearrangements in cancer

Hasty, P., & Montagna, C. (2014) · Molecular & Cellular Oncology · doi:10.4161/mco.29904 · Cited by 75 · see citing works

Coevolution of the Organization and Structure of Prokaryotic Genomes.Preprint

Touchon, M., & Rocha, E. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018168 · Cited by 63 · see citing works

Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery

Costes, A., & Lambert, S. (2012) · Biomolecules · doi:10.3390/biom3010039 · Cited by 71 · see citing works

Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells

Morales, C., García, M. J., Ribas, M., Miró, R., Muñoz, M., Caldas, C., & Peinado, M. A. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0759 · Cited by 73 · see citing works

Yra1-bound RNA–DNA hybrids cause orientation-independent transcription–replication collisions and telomere instabilityPreprint

García-Rubio, M. L., Aguilera, P., Lafuente-Barquero, J. F., Ruiz, J. F., Simon, M., Géli, V., Rondón, A. G., & Aguilera, A. (2018) · Genes & Development · doi:10.1101/gad.311274.117 · Cited by 72 · see citing works

Timeless couples G‐quadruplex detection with processing by DDX11 helicase during DNA replication

Lerner, L. K., Holzer, S., Kilkenny, M. L., Šviković, S., Murat, P., Schiavone, D., Eldridge, C. B., Bittleston, A., Maman, J. D., Branzei, D., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019104185 · Cited by 71 · see citing works

Stimulation of Gross Chromosomal Rearrangements by the Human CEB1 and CEB25 Minisatellites in Saccharomyces cerevisiae Depends on G-Quadruplexes or Cdc13

Piazza, A., Serero, A., Boulé, J.-B., Legoix-Né, P., Lopes, J., & Nicolas, A. G. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003033 · Cited by 68 · see citing works

Key Proteins of Replication Stress Response and Cell Cycle Control as Cancer Therapy Targets

Khamidullina, A. I., Abramenko, Y. E., Bruter, A. V., & Tatarskiy, V. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021263 · Cited by 71 · see citing works

Regulation of Transcript Elongation

Belogurov, G. A., & Artsimovitch, I. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104047 · Cited by 68 · see citing works

Making it or breaking it: DNA methylation and genome integrity

Sriraman, A., Debnath, T. K., Xhemalçe, B., & Miller, K. M. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200009 · Cited by 68 · see citing works

Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks

Belotserkovskii, B. P., Neil, A. J., Saleh, S. S., Shin, J. H. S., Mirkin, S. M., & Hanawalt, P. C. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1333 · Cited by 68 · see citing works

Regulation of DNA Replication through Natural Impediments in the Eukaryotic Genome

Gadaleta, M. C., & Noguchi, E. (2017) · Genes · doi:10.3390/genes8030098 · Cited by 55 · see citing works

Impediments to replication fork movement: stabilisation, reactivation and genome instability

Lambert, S., & Carr, A. M. (2013) · Chromosoma · doi:10.1007/s00412-013-0398-9 · Cited by 98 · see citing works

Eukaryotic Replication Barriers: How, Why and Where Forks Stall

Jacob, Z., Emma, L. B., & Ramsay, J. (2011) · InTech eBooks · doi:10.5772/20383 · Cited by 10 · see citing works

FBH1: A new checkpoint factor

Boyer, A.-S., & Sørensen, C. S. (2015) · Oncotarget · doi:10.18632/oncotarget.5099

Cellular regulation and stability of DNA replication forks in eukaryotic cells

Li, X., Wang, L., Liu, X., Zheng, Z., & Kong, D. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103418 · Cited by 4 · see citing works