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Semipermeable Microcapsules
Abstract
Simple methods have been developed for encapsulating aqueous solutions of protein within polymer membranes. Stable microcapsules 1 to 100 μ in diameter, with semipermeable membranes, can be made by depositing polymer around emulsified aqueous droplets, either by interfacial coacervation or by interfacial polycondensation. Aqueous suspensions of enzyme-loaded microcapsules act well on small-molecular substrates both in vitro and in vivo.
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Citations
Cited by
De Duve, C., De Barsy, T., Poole, B., Trouet, A., Tulkens, P., & Van Hoof, F. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90174-9 · Cited by 1,901
Structure and properties of pharmacologically active polymers
Ringsdorf, H. (1975) · Journal of Polymer Science: Polymer Symposia · doi:10.1002/polc.5070510111 · Cited by 1,094
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 855
Riess, J. G. (2001) · Chemical Reviews · doi:10.1021/cr970143c · Cited by 773
Advances in islet encapsulation technologies
Desai, T., & Shea, L. D. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.232 · Cited by 427
Metadata
- Authors
- Chang, T. M. S.
- Venue
- Science
- Published
- 1964-10-23
- Volume
- 146
- Issue
- 3643
- Pages
- 524-525
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4243202999
- Cited by
- 1,011
- References
- 0
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Semipermeable Microcapsules. https://app.cochat.ai/papers/10.1126/science.146.3643.524
- The paper
- Chang, T. M. S. (1964). Semipermeable Microcapsules. Science. https://doi.org/10.1126/science.146.3643.524
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
