Cited by 427Pancreatic function and diabetesTissue Engineering and Regenerative MedicineDiabetes and associated disorders

Advances in islet encapsulation technologies

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Desai, Tejal, Shea, Lonnie D.·2017·Nature Reviews Drug Discovery

Abstract

Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys insulin-producing islet cells of the pancreas. Although islet transplantation has proved to be successful for some patients with type 1 diabetes, its widespread use is limited by islet donor shortage and the requirement for lifelong immunosuppression. An encapsulation strategy that can prevent the rejection of xenogeneic islets or of stem cell-derived allogeneic islets can potentially eliminate both of these barriers. Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing us to get closer to the goal of encapsulated islet cell therapy for humans.

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  1. [54]Peterson KP, Peterson CM & Pope EJ Silica solgel encapsulation of pancreatic islets. Proc. Soc. Exp. Biol. Med 218, 365– 369 (1998). 9714081
  2. [176]US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/results/NCT02239354 (2015). 28792816
  3. [177]US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01652911 (2016). 28792816
  4. [192]US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01652911 (2016). 28792816
  5. [193]US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01739829 (2014). 28792816
  6. [194]US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT00790257 (2016). 28792816
  7. [195]US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01379729 (2013). 28792816
  8. [196]US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02239354 (2015). 28792816
  9. [197]US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02064309 (2016). 28792816
  10. [198]US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02213003 (2016). 28792816

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Authors
Desai, T., & Shea, L. D.
Affiliations
  • University of California, San Francisco (US)
  • University of Michigan (US)
Corresponding author
Desai, Tejal
Venue
Nature Reviews Drug Discovery
Published
2016-12-23
Volume
16
Issue
5
Pages
338-350
ISSN
  • 1474-1776 (ISSN-L)
  • 1474-1784
OpenAlex
W2562591732
Cited by
427
References
191
Citations by year
2026: 23 · 2025: 32 · 2024: 34 · 2023: 45 · 2022: 47 · 2021: 67 · 2020: 42 · 2019: 60 · 2018: 52 · 2017: 25
FWCI
8.73
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Drug Discovery (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Biomedical Imaging and Bioengineering (R01EB009910, R21EB000570)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
islet encapsulation, islet transplantation, type 1 diabetes, xenotransplantation, allogeneic islets, stem cell-derived islets, immunosuppression, biomaterials, nanotechnology
MeSH terms
Animals, Diabetes Mellitus, Type 1, Humans, Islets of Langerhans, Stem Cells, Tissue Donors, Islets of Langerhans Transplantation, Nanotechnology

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