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Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene
Abstract
Vaccine protection against the human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV) in animal models is proving to be a difficult task. The difficulty is due in large part to the persistent, unrelenting nature of HIV and SIV infection once infection is initiated. SIV with a constructed deletion in the auxiliary gene nef replicates poorly in rhesus monkeys and appears to be nonpathogenic in this normally susceptible host. Rhesus monkeys vaccinated with live SIV deleted in nef were completely protected against challenge by intravenous inoculation of live, pathogenic SIV. Deletion of nef or of multiple genetic elements from HIV may provide the means for creating a safe, effective, live attenuated vaccine to protect against acquired immunodeficiency syndrome (AIDS).
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Citations
Cited by
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Zufferey, R., Nagy, D., Mandel, R. J., Naldini, L., & Trono, D. (1997) · Nature Biotechnology · doi:10.1038/nbt0997-871 · Cited by 1,977
Weiss, R. A. (1993) · Science · doi:10.1126/science.8493571 · Cited by 680
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
Kyei, G. B., Dinkins, C., Davis, A. S., Roberts, E., Singh, S. B., Dong, C., Wu, L., Kominami, E., Ueno, T., Yamamoto, A., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903070 · Cited by 509
Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
Cafaro, A., Caputo, A., Fracasso, C., Maggiorella, M. T., Goletti, D., Baroncelli, S., Pace, M., Sernicola, L., Koanga-Mogtomo, M. L., Betti, M., et al. (1999) · Nature Medicine · doi:10.1038/9488 · Cited by 276
Strict Control of Human Immunodeficiency Virus Type 1 Replication by a Genetic Switch: Tet for Tat
Verhoef, K., Marzio, G., Hillen, W., Bujard, H., & Berkhout, B. (2001) · Journal of Virology · doi:10.1128/jvi.75.2.979-987.2001 · Cited by 88
Metadata
- Authors
- Daniel, M. D., Kirchhoff, F., Czajak, S. C., Sehgal, P. K., & Desrosiers, R. C.
- Venue
- Science
- Published
- 1992-12-18
- Volume
- 258
- Issue
- 5090
- Pages
- 1938-1941
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077348914
- Cited by
- 1,015
- References
- 0
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene. https://app.cochat.ai/papers/10.1126/science.1470917
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- Daniel, M. D., Kirchhoff, F., Czajak, S. C., Sehgal, P. K., & Desrosiers, R. C. (1992). Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene. Science. https://doi.org/10.1126/science.1470917
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
