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Biosynthesis of Vitamin A with Rat Intestinal Enzymes
Abstract
Vitamin A is synthesized from β-carotene in cell-free homogenates of rat intestinal mucosa, the biosynthetic enzymatic activity being present in the soluble protein fraction of the homogenate. Also required are a heat-stable factor in the particulate fraction, molecular oxygen, and bile salts. The reaction is stimulated by glutathione. The product, obtained in yields of up to 50 percent, has been identified as vitamin A aldehyde (retinal) by way of its semicarbazone derivative. The reaction mechanism involves the central cleavage of β-carotene into two molecules of retinal.
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Cited by
Plant carotenoid cleavage oxygenases and their apocarotenoid products
Auldridge, M. E., McCarty, D. R., & Klee, H. J. (2006) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2006.03.005 · Cited by 540
Filling the Gap in Vitamin A Research
von Lintig, J., & Vogt, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11915 · Cited by 449
Chemistry of the Retinoid (Visual) Cycle
Kiser, P. D., Golczak, M., & Palczewski, K. (2014) · Chemical Reviews · doi:10.1021/cr400107q · Cited by 353
Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids
Álvarez, R., Vaz, B., Gronemeyer, H., & de Lera, Á. R. (2014) · Chemical Reviews · doi:10.1021/cr400126u · Cited by 260
CMO1 Deficiency Abolishes Vitamin A Production from β-Carotene and Alters Lipid Metabolism in Mice
Hessel, S., Eichinger, A., Isken, A., Amengual, J., Hunzelmann, S., Hoeller, U., Elste, V., Hunziker, W., Goralczyk, R., Oberhauser, V., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706763200 · Cited by 259
Metadata
- Authors
- Goodman, D. S., & Huang, H. S.
- Venue
- Science
- Published
- 1965-08-20
- Volume
- 149
- Issue
- 3686
- Pages
- 879-880
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061997861
- Cited by
- 265
- References
- 0
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
