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Corticosteroid Responses to Limbic Stimulation in Man: Localization of Stimulus Sites
Abstract
Corticosteroids in human plasma and urine increase after amygdala stimulation, and plasma corticosteroids decrease after hippocampus stimulation. Five subjects underwent unilateral temporal lobectomy, and histopathologic localization of electrode sites was attempted. Localization was successful for six sites: three in basolateral amygdala and three in hippocampus.
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“Electrical stimulation of the amygdala can produce fear, anxiety, dysphoria, sympathetic autonomic arousal, social withdrawal, and cortisol release (61, 62).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [62]
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Metadata
- Authors
- Rubin, R. T., Mandell, A. J., & Crandall, P. H.
- Affiliations
- Departments of Psychiatry and Neurosurgery, University of California Center for the Health Sciences, Los Angeles 90024
- University of California, Los Angeles (US)
- Venue
- Science
- Published
- 1966-08-12
- Volume
- 153
- Issue
- 3737
- Pages
- 767-768
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976647119
- Cited by
- 148
- References
- 4
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 1 · 2012: 10
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- corticosteroids, limbic system, amygdala, hippocampus, temporal lobectomy, electrical stimulation, plasma corticosteroids, urinary corticosteroids, basolateral amygdala
- MeSH terms
- Amygdala, Blood, Electric Stimulation, Electrophysiology, Hippocampus, Humans, Urine, 17-Hydroxycorticosteroids, In Vitro Techniques
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