Plasma Corticosterone Responses to Electrical Stimulation of the Amygdaloid Complex: Cytoarchitectural Specificity
Abstract
To pursue the possibility that subdivisions within the amygdaloid complex are differentially involved in adrenocortical function, plasma samples obtained prior to and following electrical stimulation of the amygdala of urethane (1.30 g/kg) anesthetized female rats were assessed for corticosterone concentration. Hippocampal EEG, ECG, heart rate, mean arterial pressure, and respiration routinely were monitored, and timed blood samples (0.2 ml) were obtained from a catheterized artery. Blood samples were taken 0.5 min prior to and at 5, 10, 15, and 30 min after initiation of stimulation. Whereas stimulation of the central and lateral nuclei produced a decrease (p less than 0.05) in plasma corticosterone, stimulation of the basomedial, medial and posterior corticomedial nuclei resulted in increased plasma corticosterone levels (p less than 0.05). In contrast, no change in corticosterone levels were observed following sham stimulation or stimulation of several nonamygdaloid sites. Collectively, these data support the hypothesis that subdivisions within the amygdaloid complex are differentially involved in adrenocortical function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The amygdala is critical in activating the LHPA axis in response to threat and stress.
“The amygdala is critical in activating the LHPA axis in response to threat and stress (Dunn and Whitener, 1986, Feldman et al., 1995, Redgate and Fahringer, 1973), and levels of glucocorticoids are regulated via negative feedback loops at several levels of the axis including the hippocampus and PFC (Diorio et al., 1993, Jacobson and Sapolsky, 1991).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Dunn and Whitener, 1986
Cited by
Sorted by citations
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433 · see citing works
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357 · see citing works
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322 · see citing works
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
Pich, E., Lorang, M., Yeganeh, M., Rodriguez de Fonseca, F., Raber, J., Koob, G., & Weiss, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05439.1995 · Cited by 565 · see citing works
Local circuit regulation of paraventricular nucleus stress integration
Herman, J. P., Tasker, J. G., Ziegler, D. R., & Cullinan, W. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00681-5 · Cited by 274 · see citing works
The impact of developmental timing for stress and recovery
Gee, D. G., & Casey, B. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.02.001 · Cited by 245 · see citing works
“The amygdala is critical in activating the LHPA axis in response to threat and stress (Dunn and Whitener, 1986; Feldman et al., 1995; Redgate and Fahringer, 1973), and levels of glucocorticoids are regulated via negative feedback loops at several levels of the axis including the hippocampus and PFC…”
BackgroundForray, M. I., & Gysling, K. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.011 · Cited by 191 · see citing works
Neural Regulation of the Stress Response: The Many Faces of Feedback
Myers, B., McKlveen, J. M., & Herman, J. P. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9801-y · Cited by 175 · see citing works
“…al. 1991; Roozendaal et al. 1992; Feldman et al. 1994; Feldman and Weidenfeld 1998; Shepard et al. 2003), although there is considerable functional differentiation among individual amygdalar regions (Dunn and Whitener 1986; Swanson and Petrovich 1998; Sah et al. 2003; Ulrich-Lai and Herman 2009).”
- Authors
- Dunn, J. D., & Whitener, J.
- Affiliations
- Oral Roberts University (US)
- Corresponding author
- Dunn, Jon D.
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-04-01
- Volume
- 42
- Issue
- 3
- Pages
- 211-217
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2082035916
- Cited by
- 154
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 11
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- plasma corticosterone, amygdala, electrical stimulation, adrenocortical function, central nucleus, lateral nucleus, stress response, rats
- MeSH terms
- Adrenal Cortex, Amygdala, Animals, Blood Pressure, Brain Mapping, Corticosterone, Electric Stimulation, Female, Rats, Inbred Strains, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
