The DOI matches its Crossref record.
Phosphorylation of Nuclear Protein Early in the Course of Gene Activation in Lymphocytes
Abstract
Human lymphocytes treated with phytohemagglutinin undergo extensive gene activation, as evidenced by augmented synthesis of ribonucleic acids. This activation is preceded by an early stimulation in the rate of phosphorylation and dephosphorylation of nuclear proteins. This finding is consistent with a hypothesized role of phosphoproteins in the modification of chromatin structure and in modulation of the template activity of DNA in vivo.
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Cited by
The epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381
Roos, D., & Loos, J. A. (1970) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(70)90182-0 · Cited by 297
The Structure and Function of Chromatin
Comings, D. E. (1972) · Advances in Human Genetics · doi:10.1007/978-1-4757-4429-3_5 · Cited by 284
Metadata
- Authors
- Kleinsmith, L. J., Allfrey, V. G., & Mirsky, A. E.
- Venue
- Science
- Published
- 1966-11-11
- Volume
- 154
- Issue
- 3750
- Pages
- 780-781
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081561037
- Cited by
- 264
- References
- 0
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Phosphorylation of Nuclear Protein Early in the Course of Gene Activation in Lymphocytes. https://app.cochat.ai/papers/10.1126/science.154.3750.780
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- Kleinsmith, L. J., Allfrey, V. G., & Mirsky, A. E. (1966). Phosphorylation of Nuclear Protein Early in the Course of Gene Activation in Lymphocytes. Science. https://doi.org/10.1126/science.154.3750.780
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
