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Open-Field Behavior in Mice: Evidence for a Major Gene Effect Mediated by the Visual System
Abstract
In segregating F 2 , F 3 , and F 4 generations, albino mice had lower activity and higher defecation scores than pigmented animals when tested in a brightly lighted open field. These differences persisted when members of an F 5 generation were tested under white light, but largely disappeared under red light. Thus it was concluded that there is a major gene effect on the quantitative traits of open-field activity and defecation which is mediated by the visual system and that albino mice are more photophobic than pigmented mice under conditions of bright illumination.
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Research works printed but not linked: 4
- HALL, C.S., Emotional behavior in the rat III The relationship between emotionality and ambulatory activity, JOURNAL OF COMPARATIVE PSYCHOLOGY 22: 345 (1936). · DOI · Paper page
- HEGMANN J.P. THESIS U ILLINOIS (1966).
- MCCLEARN, G.E., STRAIN DIFFERENCES IN ACTIVITY OF MICE - INFLUENCE OF ILLUMINATION, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 53: 142 (1960). · DOI
- MERRELL, D.J., METHODOLOGY IN BEHAVIOR GENETICS, JOURNAL OF HEREDITY 56: 263 (1965). · doi:10.1093/oxfordjournals.jhered.a107434
Cited by
Tests for emotionality in rats and mice: A review
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Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety
Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.109 · Cited by 1,513
“Rodents live in burrows and forage at night, and are averse to bright light and open spaces (eg, Crawley, 1981; DeFries et al, 1966; File and Hyde, 1978).”
BackgroundGenetic and environmental influences on human psychological differences
Bouchard, T. J., & McGue, M. (2003) · Journal of Neurobiology · doi:10.1002/neu.10160 · Cited by 870
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
Walker, D. L., Toufexis, D. J., & Davis, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01282-2 · Cited by 838
Gould, T. D., Dao, D. T., & Kovacsics, C. E. (2009) · Neuromethods · doi:10.1007/978-1-60761-303-9_1 · Cited by 499
Metadata
- Authors
- DeFries, J. C., Hegmann, J. P., & Weir, M. W.
- Venue
- Science
- Published
- 1966-12-23
- Volume
- 154
- Issue
- 3756
- Pages
- 1577-1579
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046776858
- Cited by
- 164
- References
- 0
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Open-Field Behavior in Mice: Evidence for a Major Gene Effect Mediated by the Visual System. https://app.cochat.ai/papers/10.1126/science.154.3756.1577
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- DeFries, J. C., Hegmann, J. P., & Weir, M. W. (1966). Open-Field Behavior in Mice: Evidence for a Major Gene Effect Mediated by the Visual System. Science. https://doi.org/10.1126/science.154.3756.1577
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
