The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition
Abstract
The three-dimensional structure of a specific antibody (Fab 17/9) to a peptide immunogen from influenza virus hemagglutinin [HA1(75-110)] and two independent crystal complexes of this antibody with bound peptide (Tyr P100 -Leu P108 ) have been determined by x-ray crystallographic techniques at 2.0 Å, 2.9 Å, and 3.1 Å resolution, respectively. The nonapeptide antigen assumes a type I β turn in the antibody combining site and interacts primarily with the Fab hypervariable loops L3, H2, and H3. Comparison of the bound and unbound Fab structures shows that a major rearrangement in the H3 loop accompanies antigen binding. This conformational change results in the creation of a binding pocket for the β turn of the peptide, allowing Tyr P105 to be accommodated. The conformation of the peptide bound to the antibody shows similarity to its cognate sequence in the HA1, suggesting a possible mechanism for the cross-reactivity of this Fab with monomeric hemagglutinin. The structures of the free and antigen bound antibodies demonstrate the flexibility of the antibody combining site and provide an example of induced fit as a mechanism for antibody-antigen recognition.
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Cites
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Cited by
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
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Assessing AF2’s ability to predict structural ensembles of proteins
Riccabona, J. R., Spoendlin, F. C., Fischer, A.-L. M., Loeffler, J. R., Quoika, P. K., Jenkins, T. P., Ferguson, J. A., Smorodina, E., Laustsen, A. H., Greiff, V., et al. (2024) · Structure · doi:10.1016/j.str.2024.09.001 · Cited by 17
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(2025) · doi:10.1016/j.jsb.2025.108257 · Cited by 3
Assessing AF2’s ability to predict structural ensembles of proteins
Riccabona, J. R., Spoendlin, F. C., Fischer, A.-L. M., Loeffler, J. R., Quoika, P. K., Jenkins, T. P., Ferguson, J. A., Smorodina, E., Laustsen, A. H., Greiff, V., et al. (2024) · doi:10.1101/2024.04.16.589792 · Cited by 2
Metadata
- Authors
- Rini, J. M., Schulze-Gahmen, U., & Wilson, I. A.
- Venue
- Science
- Published
- 1992-02-21
- Volume
- 255
- Issue
- 5047
- Pages
- 959-965
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041108610
- Cited by
- 527
- References
- 35
- FWCI
- 53.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rini, J. M., Schulze-Gahmen, U., & Wilson, I. A. (1992). Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition. Science. https://doi.org/10.1126/science.1546293
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