Cited by 285Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyIon Transport and Channel Regulation

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Reversal of Diabetes Insipidus in Brattleboro Rats: Intrahypothalamic Injection of Vasopressin mRNA

Jirikowski, Gustav F., Sanna, Pietro Paolo, Maciejewski-Lenoir, Dominique, Bloom, Floyd E.·1992·Science

DOI 10.1126/science.1546298

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Abstract

Messenger RNAs occur within the axons of magnocellular hypothalamic neurons known to secrete oxytocin and vasopressin. In Brattleboro rats, which have a genetic mutation that renders them incapable of vasopressin expression and secretion and thus causes diabetes insipidus, injection into the hypothalamus of purified mRNAs from normal rat hypothalami or of synthetic copies of the vasopressin mRNA leads to selective uptake, retrograde transport, and expression of vasopressin exclusively in the magnocellular neurons. Temporary reversal of their diabetes insipidus (for up to 5 days) can be observed within hours of the injection. Intra-axonal mRNAs may represent an additional category of chemical signals for neurons.

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Authors: Jirikowski, G. F., Sanna, P. P., Maciejewski-Lenoir, D., & Bloom, F. E.
Affiliations: Scripps Research Institute (US)
ORCID: Sanna, Pietro Paolo
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1992-02-21
Volume: 255
Issue: 5047
Pages: 996-998
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1546298
OpenAlex: W2082706052
Cited by: 282
References: 20
Citations by year: 2026: 15 · 2025: 27 · 2024: 35 · 2023: 36 · 2022: 32 · 2021: 31 · 2020: 5 · 2019: 12 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 3 · 2012: 3
FWCI: 17.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ns022347-08)
National Institute of Mental Health (MH47680, P50MH047680)
National Institute of Neurological Disorders and Stroke (NS 22347-03)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: diabetes insipidus, Brattleboro rats, vasopressin, mRNA injection, intrahypothalamic injection, magnocellular neurons, retrograde transport, axonal mRNA transport, neuronal gene expression, oxytocin, hypothalamus
MeSH terms: Animals, Arginine Vasopressin, Diabetes Insipidus, Hypothalamus, Rats, Brattleboro, RNA, Messenger, Water-Electrolyte Balance, Rats

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Reversal of Diabetes Insipidus in Brattleboro Rats: Intrahypothalamic Injection of Vasopressin mRNA

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