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Reversal of Diabetes Insipidus in Brattleboro Rats: Intrahypothalamic Injection of Vasopressin mRNA
Abstract
Messenger RNAs occur within the axons of magnocellular hypothalamic neurons known to secrete oxytocin and vasopressin. In Brattleboro rats, which have a genetic mutation that renders them incapable of vasopressin expression and secretion and thus causes diabetes insipidus, injection into the hypothalamus of purified mRNAs from normal rat hypothalami or of synthetic copies of the vasopressin mRNA leads to selective uptake, retrograde transport, and expression of vasopressin exclusively in the magnocellular neurons. Temporary reversal of their diabetes insipidus (for up to 5 days) can be observed within hours of the injection. Intra-axonal mRNAs may represent an additional category of chemical signals for neurons.
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“Following initial studies in the early 1990s demonstrating that exogenous mRNA can direct protein expression in vivo, mRNA has emerged as a promising drug platform technology in recent years (Wolff et al, 1990; Jirikowski et al, 1992).”
From mRNA mediates passive vaccination against infectious agents, toxins, and tumors (2017) · cites this paper as Jirikowski et al, 1992
Citations
Cites
Characterization of oligonucleotide transport into living cells.
Loke, S. L., Stein, C. A., Zhang, X. H., Mori, K., Nakanishi, M., Subasinghe, C., Cohen, J. S., & Neckers, L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3474 · Cited by 734
Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats
Schmale, H., & Richter, D. (1984) · Nature · doi:10.1038/308705a0 · Cited by 397
Parsimony Analysis in Historical Biogeography and Coevolution: Methodological and Theoretical Update
Brooks, D. R. (1990) · Systematic Zoology · doi:10.2307/2992205 · Cited by 264
Tissue-specific expression of mouse α-amylase genes
Schibler, U., Tosi, M., Pittet, A.-C., Fabiani, L., & Wellauer, P. K. (1980) · Journal of Molecular Biology · doi:10.1016/0022-2836(80)90208-9 · Cited by 187
Axonal transport of neuropeptide encoding mRNAs within the hypothalamo‐hypophyseal tract of rats.
Mohr, E., Fehr, S., & Richter, D. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07781.x · Cited by 165
Carrazana, E. J., Pasieka, K. B., & Majzoub, J. A. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.6.2267-2274.1988 · Cited by 149
mRNA coding for oxytocin is present in axons of the hypothalamo-neurohypophysial tract.
Jirikowski, G. F., Sanna, P. P., & Bloom, F. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7400 · Cited by 149
Self-citationMurphy, D., & Carter, D. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-7-1051 · Cited by 103
Regulation of poly(A) tail size of vasopressin mRNA.
Zingg, H. H., Lefebvre, D. L., & Almazán, G. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37914-6 · Cited by 96
Independent Regulation of Neuropeptide mRNA Level and Poly(A) Tail Length
Carter, D., & Murphy, D. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83468-8 · Cited by 89
Research works printed but not linked: 6
- CARAZANNA, E.J., MOL CELL BIOL 8: 2267 (1988).
- FRANZONI, L, RAT-BRAIN RIBONUCLEASES, ACTA PHYSIOLOGICA LATINOAMERICANA 28: 185 (1978).
- IVELL, R, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 81: 1216 (1984).
- JIRIKOWSKI, G.F., MESSENGER-RNA CODING FOR OXYTOCIN IS PRESENT IN AXONS OF THE HYPOTHALAMONEUROHYPOPHYSEAL TRACT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 7400 (1990).
- McCabe, J. J., In Situ Hybridization in Brain: 73 (1985).
- Trembleau, A., Neurocytochemical Methods: 313 (1991).
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Karikó, K., Keller, J. M., Harris, V. A., Langer, D. J., & Welsh, F. A. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00355-1 · Cited by 24
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Callewaere, C., Fernette, B., Raison, D., Méchighel, P., Burlet, A. J., Calas, A., Kitabgi, P., Parsadaniantz, S. M., & Rostène, W. H. (2007) · Endocrinology · doi:10.1210/en.2007-1097 · Cited by 23
Jentsch, J. D., Arguello, P. A., & Anzivino, L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300194 · Cited by 23
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Hochmann, S., Mittermeir, M., Santic, R., Koszik, F., Griessner, L., Sonderegger, A., Hoffmann, T., Russe, E., Scheiblhofer, S., Weiss, R., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31061-w · Cited by 15
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Lu, L., & Ordway, G. A. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00057-0 · Cited by 11
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Holland, D. A., Acevedo‐Skrip, J., Barton, J. R., Thompson, R., Bowman, A. M., Dewar, E. A., Miller, D. V., Zhao, K., Swartz, A. R., & Loughney, J. W. (2024) · Vaccines · doi:10.3390/vaccines12080899 · Cited by 10
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Austin, L. A., Smith, J. S., Nahas, D. D., Danzinger, A., Secore, S., O’Donnell, G. T., Radcliffe, S., Hu, S., Perley, J., Bett, A. J., et al. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00635 · Cited by 10
Khawajakhail, R., Khan, R. U., Gondal, M. U. R., Toru, H. K., Malik, M., Iqbal, A., Malik, J., Faraz, M., & Awais, M. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102431 · Cited by 10
Harrison, P. J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91812-z · Cited by 10
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Mohr, E., & Richter, D. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90176-9 · Cited by 10
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Ankrah, P. K., Ilesanmi, A. O., Akinyemi, A. O., Lasehinde, V., Adurosakin, O. E., & Ajayi, O. H. (2023) · Cureus · doi:10.7759/cureus.46354 · Cited by 8
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Metadata
- Authors
- Jirikowski, G. F., Sanna, P. P., Maciejewski-Lenoir, D., & Bloom, F. E.
- Affiliations
- Scripps Research Institute (US)
- ORCID
- Sanna, Pietro Paolo
- Venue
- Science
- Published
- 1992-02-21
- Volume
- 255
- Issue
- 5047
- Pages
- 996-998
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082706052
- Cited by
- 282
- References
- 20
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 35 · 2023: 36 · 2022: 32 · 2021: 31 · 2020: 5 · 2019: 12 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 3 · 2012: 3
- FWCI
- 17.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ns022347-08)
- National Institute of Mental Health (MH47680, P50MH047680)
- National Institute of Neurological Disorders and Stroke (NS 22347-03)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- diabetes insipidus, Brattleboro rats, vasopressin, mRNA injection, intrahypothalamic injection, magnocellular neurons, retrograde transport, axonal mRNA transport, neuronal gene expression, oxytocin, hypothalamus
- MeSH terms
- Animals, Arginine Vasopressin, Diabetes Insipidus, Hypothalamus, Rats, Brattleboro, RNA, Messenger, Water-Electrolyte Balance, Rats
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