Cited by 285Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyIon Transport and Channel Regulation

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Reversal of Diabetes Insipidus in Brattleboro Rats: Intrahypothalamic Injection of Vasopressin mRNA

Abstract

Messenger RNAs occur within the axons of magnocellular hypothalamic neurons known to secrete oxytocin and vasopressin. In Brattleboro rats, which have a genetic mutation that renders them incapable of vasopressin expression and secretion and thus causes diabetes insipidus, injection into the hypothalamus of purified mRNAs from normal rat hypothalami or of synthetic copies of the vasopressin mRNA leads to selective uptake, retrograde transport, and expression of vasopressin exclusively in the magnocellular neurons. Temporary reversal of their diabetes insipidus (for up to 5 days) can be observed within hours of the injection. Intra-axonal mRNAs may represent an additional category of chemical signals for neurons.

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Crossref · 10.1126/science.1546298

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20 of 20 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 6

  1. CARAZANNA, E.J., MOL CELL BIOL 8: 2267 (1988).
  2. FRANZONI, L, RAT-BRAIN RIBONUCLEASES, ACTA PHYSIOLOGICA LATINOAMERICANA 28: 185 (1978).
  3. IVELL, R, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 81: 1216 (1984).
  4. JIRIKOWSKI, G.F., MESSENGER-RNA CODING FOR OXYTOCIN IS PRESENT IN AXONS OF THE HYPOTHALAMONEUROHYPOPHYSEAL TRACT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 7400 (1990).
  5. McCabe, J. J., In Situ Hybridization in Brain: 73 (1985).
  6. Trembleau, A., Neurocytochemical Methods: 313 (1991).

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Metadata

Authors
Jirikowski, G. F., Sanna, P. P., Maciejewski-Lenoir, D., & Bloom, F. E.
Affiliations
Scripps Research Institute (US)
Venue
Science
Published
1992-02-21
Volume
255
Issue
5047
Pages
996-998
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2082706052
Cited by
282
References
20
Citations by year
2026: 15 · 2025: 27 · 2024: 35 · 2023: 36 · 2022: 32 · 2021: 31 · 2020: 5 · 2019: 12 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 3 · 2012: 3
FWCI
17.86
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01ns022347-08)
  • National Institute of Mental Health (MH47680, P50MH047680)
  • National Institute of Neurological Disorders and Stroke (NS 22347-03)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
diabetes insipidus, Brattleboro rats, vasopressin, mRNA injection, intrahypothalamic injection, magnocellular neurons, retrograde transport, axonal mRNA transport, neuronal gene expression, oxytocin, hypothalamus
MeSH terms
Animals, Arginine Vasopressin, Diabetes Insipidus, Hypothalamus, Rats, Brattleboro, RNA, Messenger, Water-Electrolyte Balance, Rats

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