The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Effect of Sodium Salicylate on the Human Heat Shock Response
Abstract
Sodium salicylate, an anti-inflammatory agent, was examined for its effects on the heat shock response in cultured human cells. Salicylate activation of DNA binding by the heat shock transcription factor (HSF) was comparable to activation attained during heat shock. However, sodium salicylate did not induce heat shock gene transcription even though the HSF was bound in vivo to the heat shock elements upstream of the heat shock protein 70 (Hsp 70) gene. These results reveal that activation of the heat shock transcriptional response is a multistep process. Modulation of extracellular pH augments sensitivity to salicylate-induced activation of HSF.
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Cites
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In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR
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Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes
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Cited by
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
Morimoto, R. I. (1998) · Genes & Development · doi:10.1101/gad.12.24.3788 · Cited by 1,906
Self-citationInhibition of NF-κB by Sodium Salicylate and Aspirin
Kopp, E., & Ghosh, S. (1994) · Science · doi:10.1126/science.8052854 · Cited by 1,753
Heat shock factors: integrators of cell stress, development and lifespan
Åkerfelt, M., Morimoto, R. I., & Sistonen, L. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2938 · Cited by 1,455
Self-citationRoles of the heat shock transcription factors in regulation of the heat shock response and beyond
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Metadata
- Authors
- Jurivich, D. A., Sistonen, L., Kroes, R. A., & Morimoto, R. I.
- Venue
- Science
- Published
- 1992-03-06
- Volume
- 255
- Issue
- 5049
- Pages
- 1243-1245
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2029128612
- Cited by
- 400
- References
- 32
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jurivich, D. A., Sistonen, L., Kroes, R. A., & Morimoto, R. I. (1992). Effect of Sodium Salicylate on the Human Heat Shock Response. Science. https://doi.org/10.1126/science.1546322
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
