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Enzyme Concentrations in Tissues
Abstract
Apparent enzyme concentrations in cells and in mitochondria are calculated from data available in the literature. These values are 10 -6 to 10 -5 moles per kilogram of tissue. It is pointed out that these concentrations are much higher than those used in enzymatic studies in vitro. Metabolic interpretations of experiments in vitro should consider this additional departure from conditions in vivo.
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Citations
Cited by
On the role of organized multienzyme systems in cellular metabolism: a general synthesis
Welch, G. R. (1978) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(78)90019-6 · Cited by 260
Feedback interactions in the control of citric acid cycle activity in rat heart mitochondria
LaNoue, K. F., Bryla, J., & Williamson, J. R. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45660-3 · Cited by 181
Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria
LaNoue, K. F., & Williamson, J. R. (1971) · Metabolism · doi:10.1016/0026-0495(71)90087-4 · Cited by 152
Specific ATPases drive compartmentalized glycogen utilization in rat skeletal muscle
Nielsen, J., Dubillot, P., Stausholm, M.-L. H., & Ørtenblad, N. (2022) · Journal of General Physiology · doi:10.1085/jgp.202113071 · Cited by 18
Metadata
- Authors
- Srere, P. A.
- Venue
- Science
- Published
- 1967-11-17
- Volume
- 158
- Issue
- 3803
- Pages
- 936-937
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005456813
- Cited by
- 216
- References
- 0
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Enzyme Concentrations in Tissues. https://app.cochat.ai/papers/10.1126/science.158.3803.936
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- Srere, P. A. (1967). Enzyme Concentrations in Tissues. Science. https://doi.org/10.1126/science.158.3803.936
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
