Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria

LaNoue, Kathryn F.; Williamson, John R.

doi:10.1016/0026-0495(71)90087-4

Cited by 152Mitochondrial Function and PathologyBiochemical Acid Research StudiesAutophagy in Disease and Therapy

Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria

LaNoue, Kathryn F., Williamson, John R.·1971·Metabolism

DOI 10.1016/0026-0495(71)90087-4

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The malate-aspartate shuttle and TCA cycle are functionally coupled through shared metabolic intermediates and enzymes.
“Through shared metabolic intermediates and enzymes, the malate–aspartate shuttle and TCA cycle are functionally coupled (115).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [115]

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Authors: LaNoue, K. F., & Williamson, J. R.
Affiliations: University of Pennsylvania (US)
Venue: Metabolism
Publisher: Elsevier BV
Published: 1971-02
Volume: 20
Issue: 2
Pages: 119-140
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/0026-0495(71)90087-4
OpenAlex: W2060829865
Cited by: 152
References: 36
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 2
FWCI: 5.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: malate-aspartate shuttle, TCA cycle, heart mitochondria, citrate synthase, oxaloacetate, alpha-ketoglutarate dehydrogenase, ATP/ADP ratio, substrate-level phosphorylation, uncoupled respiration, oligomycin, acetyl-L-carnitine, rat heart
MeSH terms: Adenine Nucleotides, Animals, Aspartic Acid, Carnitine, Citric Acid Cycle, Coenzyme A, Fluorometry, Glutamates, Ketoglutaric Acids, Lactates, Malates, Mitochondria, Myocardium, NAD, Oligomycins, Oxaloacetates, Oxidation-Reduction, Oxygen Consumption, Polarography, Rats, In Vitro Techniques

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