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Sexually Antagonistic Genes: Experimental Evidence
Abstract
When selection differs between the sexes, a mutation beneficial to one sex may be harmful to the other (sexually antagonistic). Because the sexes share a common gene pool, selection in one sex can interfere with the other's adaptive evolution. Theory predicts that sexually antagonistic mutations should accumulate in tight linkage with a new sex-determining gene, even when the harm to benefit ratio is high. Genetic markers and artificial selection were used to make a pair of autosomal genes segregate like a new pair of sex-determining genes in a Drosophila melanogaster model system. A 29-generation study provides experimental evidence that sexually antagonistic genes may be common in nature and will accumulate in response to a new sex-determining gene.
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Cited by
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True, J. R., & Haag, E. S. (2001) · Evolution & Development · doi:10.1046/j.1525-142x.2001.003002109.x · Cited by 678
Arnold, A. P., & Chen, X. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.001 · Cited by 587
The elements of a scientific theory of self‐deception
TRIVERS, R. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06619.x · Cited by 408
Sex chromosomes and brain gender
Arnold, A. P. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1494 · Cited by 368
Deng, X., Hiatt, J. B., Nguyen, D. K., Ercan, S., Sturgill, D., Hillier, L. W., Schlesinger, F., Davis, C. A., Reinke, V. J., Gingeras, T. R., et al. (2011) · Nature Genetics · doi:10.1038/ng.948 · Cited by 286
Metadata
- Authors
- Rice, W. R.
- Venue
- Science
- Published
- 1992-06-05
- Volume
- 256
- Issue
- 5062
- Pages
- 1436-1439
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985993046
- Cited by
- 350
- References
- 0
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
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