The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster
Open accessAbstract
Many animal species use a chromosome-based mechanism of sex determination, which has led to the coordinate evolution of dosage-compensation systems. Dosage compensation not only corrects the imbalance in the number of X chromosomes between the sexes but also is hypothesized to correct dosage imbalance within cells that is due to monoallelic X-linked expression and biallelic autosomal expression, by upregulating X-linked genes twofold (termed 'Ohno's hypothesis'). Although this hypothesis is well supported by expression analyses of individual X-linked genes and by microarray-based transcriptome analyses, it was challenged by a recent study using RNA sequencing and proteomics. We obtained new, independent RNA-seq data, measured RNA polymerase distribution and reanalyzed published expression data in mammals, C. elegans and Drosophila. Our analyses, which take into account the skewed gene content of the X chromosome, support the hypothesis of upregulation of expressed X-linked genes to balance expression of the genome.
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Cited by
Sex-Specific Gene Expression and Life Span Regulation
Tower, J. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.07.002 · Cited by 118
Metadata
- Authors
- Deng, X., Hiatt, J. B., Nguyen, D. K., Ercan, S., Sturgill, D., Hillier, L. W., Schlesinger, F., Davis, C. A., Reinke, V. J., Gingeras, T. R., Shendure, J., Waterston, R. H., Oliver, B., Lieb, J. D., & Disteche, C. M.
- Venue
- Nature Genetics
- Published
- 2011-10-23
- Volume
- 43
- Issue
- 12
- Pages
- 1179-1185
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2086399711
- Cited by
- 286
- References
- 58
- FWCI
- 15.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Deng, X., Hiatt, J. B., Nguyen, D. K., Ercan, S., Sturgill, D., Hillier, L. W., Schlesinger, F., Davis, C. A., Reinke, V. J., Gingeras, T. R., Shendure, J., Waterston, R. H., Oliver, B., Lieb, J. D., & Disteche, C. M. (2011). Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster. Nature Genetics. https://doi.org/10.1038/ng.948
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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