The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Exhaustive Matching of the Entire Protein Sequence Database
Abstract
The entire protein sequence database has been exhaustively matched. Definitive mutation matrices and models for scoring gaps were obtained from the matching and used to organize the sequence database as sets of evolutionarily connected components. The methods developed are general and can be used to manage sequence data generated by major genome sequencing projects. The alignments made possible by the exhaustive matching are the starting point for successful de novo prediction of the folded structures of proteins, for reconstructing sequences of ancient proteins and metabolisms in ancient organisms, and for obtaining new perspectives in structural biochemistry.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288
Modern metabolism as a palimpsest of the RNA world
Benner, S. A., Ellington, A. D., & Tauer, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7054 · Cited by 478
Self-citationThe Human Genome Project: creating an infrastructure for biology and medicine
Yager, T. D., Nickerson, D. A., & Hood, L. E. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90177-w · Cited by 22
Cited by
Amino acid substitution matrices from protein blocks.
Henikoff, S., & Henikoff, J. G. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10915 · Cited by 6,218
Determining Divergence Times of the Major Kingdoms of Living Organisms with a Protein Clock
Doolittle, R. F., Feng, D.-F., Tsang, S., Cho, G., & Little, E. (1996) · Science · doi:10.1126/science.271.5248.470 · Cited by 581
Cherepanov, P., Devroe, E., Silver, P. A., & Engelman, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406307200 · Cited by 287
Schierwater, B., Eitel, M., Jakob, W., Osigus, H.-J., Hadrys, H., Dellaporta, S. L., Kolokotronis, S.-O., & DeSalle, R. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000020 · Cited by 260
Brooks, D. J., Fresco, J. R., Lesk, A. M., & Singh, M. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003988 · Cited by 192
Metadata
- Authors
- Gonnet, G. H., Cohen, M. A., & Benner, S. A.
- Venue
- Science
- Published
- 1992-06-05
- Volume
- 256
- Issue
- 5062
- Pages
- 1443-1445
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004575181
- Cited by
- 840
- References
- 3
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Exhaustive Matching of the Entire Protein Sequence Database. https://app.cochat.ai/papers/10.1126/science.1604319
- The paper
- Gonnet, G. H., Cohen, M. A., & Benner, S. A. (1992). Exhaustive Matching of the Entire Protein Sequence Database. Science. https://doi.org/10.1126/science.1604319
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
