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NF-κB Subunit Regulation in Nontransformed CD4 + T Lymphocytes
Abstract
Regulation of interleukin-2 (IL-2) gene expression by the p50 and p65 subunits of the DNA binding protein NF-κB was studied in nontransformed CD4 + T lymphocyte clones. A homodimeric complex of the NF-κB p50 subunit was found in resting T cells. The amount of p50-p50 complex decreased after full antigenic stimulation, whereas the amount of the NF-κB p50-p65 heterodimer was increased. Increased expression of the IL-2 gene and activity of the IL-2 κB DNA binding site correlated with a decrease in the p50-p50 complex. Overexpression of p50 repressed IL-2 promoter expression. The switch from p50-p50 to p50-p65 complexes depended on a protein that caused sequestration of the p50-p50 complex in the nucleus.
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Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252
Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., & Akira, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10193 · Cited by 959
Scheinman, R. I., Gualberto, A., Jewell, C. M., Cidlowski, J. A., & Baldwin, A. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.943 · Cited by 819
Das, J., Chen, C.-H., Yang, L., Cohn, L., Ray, P., & Ray, A. (2001) · Nature Immunology · doi:10.1038/83158 · Cited by 518
Metadata
- Authors
- Kang, S.-M., Tran, A.-C., Grilli, M., & Lenardo, M. J.
- Venue
- Science
- Published
- 1992-06-05
- Volume
- 256
- Issue
- 5062
- Pages
- 1452-1456
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1991606993
- Cited by
- 314
- References
- 0
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kang, S.-M., Tran, A.-C., Grilli, M., & Lenardo, M. J. (1992). NF-κB Subunit Regulation in Nontransformed CD4 + T Lymphocytes. Science. https://doi.org/10.1126/science.1604322
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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