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Stage-Specific Adhesion of Leishmania Promastigotes to the Sandfly Midgut
Abstract
Although leishmaniasis is transmitted to humans almost exclusively by the bite of infected phlebotomine sandflies, little is known about the molecules controlling the survival and development of Leishmania parasites in their insect vectors. Adhesion of Leishmania promastigotes to the midgut epithelial cells of the sandfly was found to be an inherent property of noninfective-stage promastigotes, which was lost during their transformation to metacyclic forms, thus permitting the selective release of infective-stage parasites for subsequent transmission by bite. Midgut attachment and release was found to be controlled by specific developmental modifications in terminally exposed saccharides on lipophosphoglycan, the major surface molecule on Leishmania promastigotes.
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Citations
Cited by
Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies
Bates, P. A. (2007) · International Journal for Parasitology · doi:10.1016/j.ijpara.2007.04.003 · Cited by 607
A Role for Insect Galectins in Parasite Survival
Kamhawi, S., Ramalho-Ortigao, M., Pham, V. M., Kumar, S., Lawyer, P. G., Turco, S. J., Barillas-Mury, C., Sacks, D. L., & Valenzuela, J. G. (2004) · Cell · doi:10.1016/j.cell.2004.10.009 · Cited by 266
Self-citationAcquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi
Wilson, M. E., Vorhies, R. W., Andersen, K. A., & Britigan, B. E. (1994) · Infection and Immunity · doi:10.1128/iai.62.8.3262-3269.1994 · Cited by 79
ILG, T., HARBECKE, D., WIESE, M., & OVERATH, P. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18283.x · Cited by 62
Metadata
- Authors
- Pimenta, P. F. P., Turco, S. J., McConville, M. J., Lawyer, P. G., Perkins, P. V., & Sacks, D. L.
- Venue
- Science
- Published
- 1992-06-26
- Volume
- 256
- Issue
- 5065
- Pages
- 1812-1815
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966835460
- Cited by
- 236
- References
- 0
- FWCI
- 23.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Stage-Specific Adhesion of Leishmania Promastigotes to the Sandfly Midgut. https://app.cochat.ai/papers/10.1126/science.1615326
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- Pimenta, P. F. P., Turco, S. J., McConville, M. J., Lawyer, P. G., Perkins, P. V., & Sacks, D. L. (1992). Stage-Specific Adhesion of Leishmania Promastigotes to the Sandfly Midgut. Science. https://doi.org/10.1126/science.1615326
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
