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Chemotactic and Anaphylatoxic Fragment Cleaved from the Fifth Component of Guinea Pig Complement
Abstract
The fifth component of guinea pig complement, with a sedimentation coefficient 7.8 S , is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4 S and 1.5 S . The smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig ileum.
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Citations
Cited by
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Hugh, T. E. (1984) · Springer Seminars in Immunopathology · doi:10.1007/bf01893020 · Cited by 259
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Vandendriessche, S., Cambier, S., Proost, P., & Marques, P. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.624025 · Cited by 178
Opsonins: Their function, identity, and clinical significance
Winkelstein, J. A. (1973) · The Journal of Pediatrics · doi:10.1016/s0022-3476(73)80062-9 · Cited by 69
Toll-like receptor 2 confers partial neuroprotection during prion disease
Carroll, J. A., Race, B., Williams, K., & Chesebro, B. (2018) · PLOS ONE · doi:10.1371/journal.pone.0208559 · Cited by 22
Metadata
- Authors
- Shin, H. S., Snyderman, R., Friedman, E., Mellors, A., & Mayer, M. M.
- Venue
- Science
- Published
- 1968-10-18
- Volume
- 162
- Issue
- 3851
- Pages
- 361-363
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090109532
- Cited by
- 281
- References
- 0
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Chemotactic and Anaphylatoxic Fragment Cleaved from the Fifth Component of Guinea Pig Complement. https://app.cochat.ai/papers/10.1126/science.162.3851.361
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- Shin, H. S., Snyderman, R., Friedman, E., Mellors, A., & Mayer, M. M. (1968). Chemotactic and Anaphylatoxic Fragment Cleaved from the Fifth Component of Guinea Pig Complement. Science. https://doi.org/10.1126/science.162.3851.361
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
