Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,442

The DOI matches its Crossref record.

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

Jilka, Robert L., Hangoc, Giao, Girasole, Giuseppe, Passeri, Giovanni, Williams, Daniel C., Abrams, John S., Boyce, Brendan, Broxmeyer, Hal, Manolagas, Stavros C.·1992·Science
DOI 10.1126/science.1621100
Open this paper in CoChat — free account

Abstract

Osteoclasts, the cells that resorb bone, develop from hematopoietic precursors of the bone marrow under the control of factors produced in their microenvironment. The cytokine interleukin-6 can promote hematopoiesis and osteoclastogenesis. Interleukin-6 production by bone and marrow stromal cells is suppressed by 17β-estradiol in vitro. In mice, estrogen loss (ovariectomy) increased the number of colony-forming units for granulocytes and macrophages, enhanced osteoclast development in ex vivo cultures of marrow, and increased the number of osteoclasts in trabecular bone. These changes were prevented by 17β-estradiol or an antibody to interleukin-6. Thus, estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.1621100

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 30

  1. BARZEL, U.S., ESTROGENS IN THE PREVENTION AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS - A REVIEW, AMERICAN JOURNAL OF MEDICINE 85: 847 (1988). · DOI
  2. BATAILLE, JOURNAL OF CLINICAL INVESTIGATION 88: 62 (1991). · DOI · Paper page
  3. BROXMEYER, H. E., CANCER CELLS-A MONTHLY REVIEW 3: 480 (1991).
  4. BROXMEYER, H.E., INFLUENCE OF MURINE MAST-CELL GROWTH-FACTOR (C-KIT LIGAND) ON COLONY FORMATION BY MOUSE MARROW HEMATOPOIETIC PROGENITOR CELLS, EXPERIMENTAL HEMATOLOGY 19: 143 (1991).
  5. ERNST, M, ESTRADIOL EFFECTS ON PROLIFERATION, MESSENGER RIBONUCLEIC-ACID FOR COLLAGEN AND INSULIN-LIKE GROWTH FACTOR-I, AND PARATHYROID HORMONE-STIMULATED ADENYLATE-CYCLASE ACTIVITY IN OSTEOBLASTIC CELLS FROM CALVARIAE AND LONG BONES, ENDOCRINOLOGY 125: 825 (1989). · DOI · Paper page
  6. GIRASOLE, G, 17-BETA-ESTRADIOL INHIBITS INTERLEUKIN-6 PRODUCTION BY BONE MARROW-DERIVED STROMAL CELLS AND OSTEOBLASTS INVITRO - A POTENTIAL MECHANISM FOR THE ANTIOSTEOPOROTIC EFFECT OF ESTROGENS, JOURNAL OF CLINICAL INVESTIGATION 89: 883 (1992). · DOI · Paper page
  7. GRAVES, L, COMPARISON OF BONE AND PARATHYROID-HORMONE AS STIMULATORS OF OSTEOCLAST DEVELOPMENT AND ACTIVITY IN CALVARIAL CELL-CULTURES FROM NORMAL AND OSTEOPETROTIC (MI/MI) MICE, JOURNAL OF CELLULAR PHYSIOLOGY 145: 102 (1990). · doi:10.1002/jcp.1041450115
  8. GRAY, T.K., ESTRADIOL STIMULATES INVITRO THE SECRETION OF INSULIN-LIKE GROWTH-FACTORS BY THE CLONAL OSTEOBLASTIC CELL-LINE, UMR106, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 158: 407 (1989). · DOI
  9. HATTERSLEY, G, CALCITONIN RECEPTORS AS MARKERS FOR OSTEOCLASTIC DIFFERENTIATION - CORRELATION BETWEEN GENERATION OF BONE-RESORPTIVE CELLS AND CELLS THAT EXPRESS CALCITONIN RECEPTORS IN MOUSE BONE-MARROW CULTURES, ENDOCRINOLOGY 125: 1606 (1989). · DOI
  10. HATTERSLEY, G, IDENTIFICATION OF OSTEOCLAST PRECURSORS IN MULTILINEAGE HEMATOPOIETIC COLONIES, ENDOCRINOLOGY 128: 259 (1991). · DOI
  11. HAWLEY, T.S., LEUKOCYTOSIS IN MICE FOLLOWING LONG-TERM RECONSTITUTION WITH GENETICALLY-MODIFIED BONE-MARROW CELLS CONSTITUTIVELY EXPRESSING INTERLEUKIN-1 ALPHA OR INTERLEUKIN-6, LEUKEMIA RESEARCH 15: 659 (1991). · doi:10.1016/0145-2126(91)90068-5
  12. HEANEY, R.P., MENOPAUSAL CHANGES IN BONE REMODELING, JOURNAL OF LABORATORY AND CLINICAL MEDICINE 92: 964 (1978).
  13. KALU, D.N., THE OVARIECTOMIZED RAT MODEL OF POSTMENOPAUSAL BONE LOSS, BONE AND MINERAL 15: 175 (1991). · DOI · Paper page
  14. KLEIN, B, MURINE ANTI-INTERLEUKIN-6 MONOCLONAL-ANTIBODY THERAPY FOR A PATIENT WITH PLASMA-CELL LEUKEMIA, BLOOD 78: 1198 (1991). · DOI · Paper page
  15. KURIHARA, N, IDENTIFICATION OF COMMITTED MONONUCLEAR PRECURSORS FOR OSTEOCLAST-LIKE CELLS FORMED IN LONG-TERM HUMAN MARROW CULTURES, ENDOCRINOLOGY 126: 2733 (1990). · DOI · Paper page
  16. KURIHARA, N, OSTEOTROPIC FACTOR RESPONSIVENESS OF HIGHLY PURIFIED POPULATIONS OF EARLY AND LATE PRECURSORS FOR HUMAN MULTINUCLEATED CELLS EXPRESSING THE OSTEOCLAST PHENOTYPE, JOURNAL OF BONE AND MINERAL RESEARCH 6: 257 (1991). · DOI
  17. LINDSAY, R, LONG-TERM PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS BY ESTROGEN - EVIDENCE FOR AN INCREASED BONE MASS AFTER DELAYED ONSET OF ESTROGEN-TREATMENT, LANCET 1: 1038 (1976).
  18. LIU, C.C., BONE-CELL CHANGES IN ESTROGEN-INDUCED BONE-MASS INCREASE IN MICE - DISSOCIATION OF OSTEOCLASTS FROM BONE SURFACES, ANATOMICAL RECORD 229: 240 (1991). · DOI
  19. OTSUKA, T, THE EFFECTS OF INTERLEUKIN-6 AND INTERLEUKIN-3 ON EARLY HEMATOPOIETIC EVENTS IN LONG-TERM CULTURES OF HUMAN MARROW, EXPERIMENTAL HEMATOLOGY 19: 1042 (1991).
  20. PACIFICI, R, EFFECT OF SURGICAL MENOPAUSE AND ESTROGEN REPLACEMENT ON CYTOKINE RELEASE FROM HUMAN BLOOD MONONUCLEAR-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 5134 (1991).
  21. POJDA, Z, INVIVO EFFECTS OF HUMAN RECOMBINANT INTERLEUKIN-6 ON HEMATOPOIETIC STEM AND PROGENITOR CELLS AND CIRCULATING BLOOD-CELLS IN NORMAL MICE, EXPERIMENTAL HEMATOLOGY 18: 1034 (1990).
  22. ROODMAN, G.D., INTERLEUKIN-6 - A POTENTIAL AUTOCRINE PARACRINE FACTOR IN PAGETS-DISEASE OF BONE, JOURNAL OF CLINICAL INVESTIGATION 89: 46 (1992). · DOI · Paper page
  23. STARNES, H.F., ANTI-IL-6 MONOCLONAL-ANTIBODIES PROTECT AGAINST LETHAL ESCHERICHIA-COLI INFECTION AND LETHAL TUMOR-NECROSIS-FACTOR-ALPHA CHALLENGE IN MICE, JOURNAL OF IMMUNOLOGY 145: 4185 (1990). · DOI · Paper page
  24. TAKAHASHI, N, INDUCTION OF CALCITONIN RECEPTORS BY 1-ALPHA, 25-DIHYDROXYVITAMIN D3 IN OSTEOCLAST-LIKE MULTINUCLEATED CELLS FORMED FROM MOUSE BONE-MARROW CELLS, ENDOCRINOLOGY 123: 1504 (1988). · DOI · Paper page
  25. TAKAHASHI, N, OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION, ENDOCRINOLOGY 123: 2600 (1988). · DOI · Paper page
  26. TAKANOYAMAMOTO, T, DIRECT EFFECTS OF 17-BETA-ESTRADIOL ON TRABECULAR BONE IN OVARIECTOMIZED RATS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 2172 (1990).
  27. TURNER, R.T., TAMOXIFEN INHIBITS OSTEOCLAST-MEDIATED RESORPTION OF TRABECULAR BONE IN OVARIAN HORMONE-DEFICIENT RATS, ENDOCRINOLOGY 122: 1146 (1988). · DOI · Paper page
  28. ULICH, T.R., ENDOTOXIN-INDUCED CYTOKINE GENE-EXPRESSION INVIVO .3. IL-6 MESSENGER-RNA AND SERUM-PROTEIN EXPRESSION AND THE INVIVO HEMATOLOGIC EFFECTS OF IL-6, JOURNAL OF IMMUNOLOGY 146: 2316 (1991). · DOI
  29. Williams D. Connective Tissue Research in press.
  30. WONG, G.G., STIMULATION OF MURINE HEMATOPOIETIC COLONY FORMATION BY HUMAN IL-6, JOURNAL OF IMMUNOLOGY 140: 3040 (1988). · DOI · Paper page

Cited by

See all 1,442

Metadata

Authors
Jilka, R. L., Hangoc, G., Girasole, G., Passeri, G., Williams, D. C., Abrams, J. S., Boyce, B., Broxmeyer, H., & Manolagas, S. C.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1992-07-03
Volume
257
Issue
5066
Pages
88-91
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1621100
OpenAlex
W1996028579
Cited by
1,442
References
0
FWCI
24.05
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6. https://app.cochat.ai/papers/10.1126/science.1621100
The paper
Jilka, R. L., Hangoc, G., Girasole, G., Passeri, G., Williams, D. C., Abrams, J. S., Boyce, B., Broxmeyer, H., & Manolagas, S. C. (1992). Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6. Science. https://doi.org/10.1126/science.1621100

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.