The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism
Abstract
The course of infection with the protozoan parasite Leishmania is determined in part by their early replication in macrophages, the exclusive host cells for these organisms. Although factors contributing to the survival of Leishmania are not well understood, cytokines influence the course of infection. Transforming growth factor-β (TGF-β) is a multipotential cytokine with diverse effects on cells of the immune system, including down-regulation of certain macrophage functions. Leishmanial infection induced the production of active TGF-β, both in vitro and in vivo. TGF-β was important for determining in vivo susceptibility to experimental leishmanial infection.
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Expression and secretion of type beta transforming growth factor by activated human macrophages.
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Deactivation of macrophages by transforming growth factor-β
Tsunawaki, S., Sporn, M., Ding, A., & Nathan, C. (1988) · Nature · doi:10.1038/334260a0 · Cited by 861
Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.
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Scott, P., Natovitz, P., Coffman, R. L., Pearce, E., & Sher, A. (1988) · The Journal of experimental medicine · doi:10.1084/jem.168.5.1675 · Cited by 705
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Self-citation
Cited by
REGULATION OF IMMUNE RESPONSES BY TGF-β
Letterio, J. J., & Roberts, A. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.137 · Cited by 1,890
Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.
Vodovotz, Y., Bogdan, C., Paik, J., Xie, Q. W., & Nathan, C. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.2.605 · Cited by 655
Iwasaki, A., & Kelsall, B. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.229 · Cited by 640
Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
Sanjabi, S., Oh, S. A., & Li, M. O. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022236 · Cited by 621
Scharton, T. M., & Scott, P. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.2.567 · Cited by 608
Metadata
- Authors
- Barral-Netto, M., Barral, A., Brownell, C. E., Skeiky, Y. A. W., Ellingsworth, L. R., Twardzik, D. R., & Reed, S. G.
- Venue
- Science
- Published
- 1992-07-24
- Volume
- 257
- Issue
- 5069
- Pages
- 545-548
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079140747
- Cited by
- 434
- References
- 17
- FWCI
- 35.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism. https://app.cochat.ai/papers/10.1126/science.1636092
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- Barral-Netto, M., Barral, A., Brownell, C. E., Skeiky, Y. A. W., Ellingsworth, L. R., Twardzik, D. R., & Reed, S. G. (1992). Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism. Science. https://doi.org/10.1126/science.1636092
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.