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Transforming growth factor- beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.
Abstract
Transforming growth factor-beta (TGF-beta), a product of neoplastic and hemopoietic cells, is a bifunctional regulator of the immune response. At femtomolar concentrations, TGF-beta stimulates monocyte migration, and picomolar quantities induce synthesis of monocyte growth factors, including IL-1, that may promote tissue repair by regulating fibrosis and angiogenesis. Paradoxically, TGF-beta at picomolar concentrations also blocks the ability of IL-1 to stimulate lymphocyte proliferation. At 0.01 to 1.0 ng/ml, TGF-beta 1 and its homologue, TGF-beta 2, suppress the IL-1-dependent murine thymocyte proliferation assay. TGF-beta also inhibits human peripheral blood T lymphocyte mitogenesis. Inhibition of cell division appears to occur after activation of the lymphocytes inasmuch as neither gene expression nor translation of IL-2R is suppressed. Furthermore, TGF-beta does not block synthesis of IL-2. Therefore, TGF-beta 1 and TGF-beta 2 likely act at a site distal to IL-1 to block lymphocyte DNA synthesis. These findings suggest that TGF-beta secreted in an inflammatory site may be beneficial in diminishing lymphocyte function while promoting fibrosis and tissue repair. However, TGF-beta generated by neoplastic tissues may provide a mechanism for unrestricted tumor cell growth through its selective immunosuppressive effects.
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Cited by
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Basic biology and role of interleukin‐17 in immunity and inflammation
Zenobia, C., & Hajishengallis, G. (2015) · Periodontology 2000 · doi:10.1111/prd.12083 · Cited by 470
Fibroblast migration is mediated by CD44-dependent TGFβ activation
Acharya, P. S., Majumdar, S., Jacob, M., Hayden, J., Mrass, P., Weninger, W., Assoian, R. K., & Puré, E. (2008) · Journal of Cell Science · doi:10.1242/jcs.021683 · Cited by 157
Demidem, A., Taylor, J. R., Grammer, S. F., & Streilein, J. W. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12469761 · Cited by 50
Metadata
- Authors
- Wahl, S. M., Hunt, D. A., Wong, H. L., Dougherty, S., McCartney-Francis, N., Wahl, L. M., Ellingsworth, L., Schmidt, J. A., Hall, G., Roberts, A. B., & Sporn, M. B.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-05-01
- Volume
- 140
- Issue
- 9
- Pages
- 3026-3032
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1541589221
- Cited by
- 389
- References
- 0
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transforming growth factor- beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation. https://app.cochat.ai/papers/10.4049/jimmunol.140.9.3026
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- Wahl, S. M., Hunt, D. A., Wong, H. L., Dougherty, S., McCartney-Francis, N., Wahl, L. M., Ellingsworth, L., Schmidt, J. A., Hall, G., Roberts, A. B., & Sporn, M. B. (1988). Transforming growth factor- beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.140.9.3026
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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