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An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4
Abstract
Murine interleukin-4 (IL-4) exhibits potent antitumor activity when present at the site of tumor cell challenge. Associated with tumor cell death is the appearance of an inflammatory infiltrate comprised predominantly of eosinophils and macrophages, but with few lymphocytes. Antibodies that specifically block the accumulation of granulocytes at the site of inflammation were injected in vivo to define the cell type responsible for the antitumor action of IL-4. These studies implicate eosinophils in IL-4-mediated tumor cytotoxicity. The lymphoid-independent nature of IL-4 action is supported by the analysis of mutant mouse strains with defined lymphocyte immunodeficiencies. The observed regression of established tumor masses by localized IL-4 action provides a rationale for exploring IL-4-mediated tumor killing as a potential therapy for human malignant disorders.
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Cited by
Opal, S. M., & DePalo, V. A. (2000) · Chest · doi:10.1378/chest.117.4.1162 · Cited by 1,752
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Rothenberg, M. E., & Hogan, S. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090720 · Cited by 1,356
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Engblom, C., Pfirschke, C., & Pittet, M. J. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.54 · Cited by 788
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Metadata
- Authors
- Tepper, R. I., Coffman, R. L., & Leder, P.
- Venue
- Science
- Published
- 1992-07-24
- Volume
- 257
- Issue
- 5069
- Pages
- 548-551
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046555621
- Cited by
- 541
- References
- 0
- FWCI
- 14.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4. https://app.cochat.ai/papers/10.1126/science.1636093
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- Tepper, R. I., Coffman, R. L., & Leder, P. (1992). An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4. Science. https://doi.org/10.1126/science.1636093
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
