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Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation
Abstract
Chronic monopolar electrodes were implanted in the region of the midbrain central gray in eight rats. In three rats, continuous 60 cycle-per-second sine-wave stimulation resulted in an electrical analgesia defined by the elimination of responses to aversive stimulation while general motor responsiveness was retained. Exploratory laparotomy was carried out in these animals during continuous brain stimulation without the use of chemical anesthetics. Following surgery, brain stimulation was terminated, and responses to aversive stimuli returned. Electrodes effective in inducing electrical analgesia at the lowest currents were located at the dorsolateral perimeter of the midbrain central gray. It was concluded that focal brain stimulation in this region can induce analgesia in the absence of diffusely applied "whole brain" stimulation.
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Cited by
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Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
Chronic pain and medullary descending facilitation
Porreca, F. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02157-4 · Cited by 1,007
Metadata
- Authors
- Reynolds, D. V.
- Venue
- Science
- Published
- 1969-04-25
- Volume
- 164
- Issue
- 3878
- Pages
- 444-445
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092767025
- Cited by
- 1,389
- References
- 0
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reynolds, D. V. (1969). Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation. Science. https://doi.org/10.1126/science.164.3878.444
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
