Pathophysiology of migraine: a disorder of sensory processing

Nitric oxide: physiology, pathophysiology, and pharmacology.

Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition

Arnold, M. (2018) · Cephalalgia · doi:10.1177/0333102417738202 · Cited by 11,090 · see citing works

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888 · see citing works

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291 · see citing works

The International Classification of Headache Disorders, 3rd edition (beta version)

Headache Classification Committee of the International Headache Society (IHS) (2013) · Cephalalgia · doi:10.1177/0333102413485658 · Cited by 8,229 · see citing works

Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging

Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700 · see citing works

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414 · see citing works

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.

Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,143 · see citing works

Stress and the brain: from adaptation to disease

de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works

Interplay between Cortical Spreading Depolarization and Seizures

Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,718 · see citing works

Impact of sleep debt on metabolic and endocrine function

Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,672 · see citing works

Identification and expression cloning of a leptin receptor, OB-R.

Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works

Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging

Mori, S., Crain, B. J., Chacko, V. P., & van Zijl, P. C. M. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199902)45:2 · Cited by 3,479 · see citing works

Flunarizine in Prophylaxis of Childhood Migraine: A Double-Blind, Placebo-Controlled, Crossover Study

Sorge, F., Simone, R. D., Marano, E., Nolano, M., Orefice, G., & Carrieri, P. B. (1988) · Cephalalgia · doi:10.1046/j.1468-2982.1988.0801001.x · Cited by 3,464 · see citing works

Narcolepsy in orexin Knockout Mice

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095 · see citing works

Descending control of pain

Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035 · see citing works

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

McKemy, D. D., Neuhausser, W., & Julius, D. J. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,716 · see citing works

SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

Leão, A. A. P. (1944) · Journal of Neurophysiology · doi:10.1152/jn.1944.7.6.359 · Cited by 2,711 · see citing works

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613 · see citing works

Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index

Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477 · cited 2× · see citing works

A Report on the Journal 2004

Goadsby, P. J. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00711.x · Cited by 2,381 · see citing works

A TRP Channel that Senses Cold Stimuli and Menthol

Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361 · see citing works

Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4

Ophoff, R. A., Terwindt, G. M., Vergouwe, M. N., van Eijk, R., Oefner, P. J., Hoffman, S. M. G., Lamerdin, J. E., Mohrenweiser, H. W., Bulman, D. E., Ferrari, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81373-2 · Cited by 2,337 · see citing works

Migraine prevalence, disease burden, and the need for preventive therapy

Lipton, R. B., Bigal, M. E., Diamond, M., Freitag, F., Reed, M. L., & Stewart, W. F. (2007) · Neurology · doi:10.1212/01.wnl.0000252808.97649.21 · Cited by 2,337 · see citing works

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

Rosenfeld, M. G., Mermod, J.-J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., & Evans, R. M. (1983) · Nature · doi:10.1038/304129a0 · Cited by 2,302 · see citing works

Prevalence and Burden of Migraine in the United States: Data From the American Migraine Study II

Lipton, R. B., Stewart, W. F., Diamond, S., Diamond, M. L., & Reed, M. (2001) · Headache: The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2001.041007646.x · Cited by 2,268 · see citing works

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

McLatchie, L. M., Fraser, N. J., Main, M. J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M. G., & Foord, S. M. (1998) · Nature · doi:10.1038/30666 · Cited by 2,134 · see citing works

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

Amara, S. G., Jonas, V., Rosenfeld, M. G., Ong, E. S., & Evans, R. M. (1982) · Nature · doi:10.1038/298240a0 · Cited by 2,105 · see citing works

Drugs of abuse: anatomy, pharmacology and function of reward pathways

Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068 · see citing works

Migraine — Current Understanding and Treatment

Goadsby, P. J., Lipton, R. B., & Ferrari, M. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmra010917 · Cited by 1,920 · see citing works

Resetting central and peripheral circadian oscillators in transgenic rats

Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works

The brain reward circuitry in mood disorders

Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works

Molecular, pharmacological and functional diversity of 5-HT receptors

Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,869 · see citing works

Hypocretin (orexin) deficiency in human narcolepsy

Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776 · see citing works

Mitochondrial Respiratory-Chain Diseases

DiMauro, S., & Schon, E. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022567 · Cited by 1,650 · see citing works

Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

Goadsby, P. J., Edvinsson, L. I., & Ekman, R. (1990) · Annals of Neurology · doi:10.1002/ana.410280213 · Cited by 1,603 · see citing works

Lost productive time and cost due to common pain conditions in the US workforce

Stewart, W. F. (2003) · JAMA · doi:10.1001/jama.290.18.2443 · Cited by 1,570 · see citing works

Mechanisms of migraine aura revealed by functional MRI in human visual cortex

Hadjikhani, N. K., del Río, M. S., Wu, O., Schwartz, D., Bakker, D., Fischl, B. R., Kwong, K. K., Cutrer, F. M., Rosen, B. R., Tootell, R. B. H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071582498 · Cited by 1,521 · see citing works

The role of neuropeptide Y in the antiobesity action of the obese gene product

Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498 · see citing works

Identification of targets of leptin action in rat hypothalamus.

Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,475 · see citing works

An h <i>Per2</i> Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460 · see citing works

The menthol receptor TRPM8 is the principal detector of environmental cold

Bautista, D. M., Siemens, J., Glazer, J. M., Tsuruda, P. R., Basbaum, A. I., Stucky, C. L., Jordt, S. E., & Julius, D. J. (2007) · Nature · doi:10.1038/nature05910 · Cited by 1,392 · see citing works

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

Reynolds, D. V. (1969) · Science · doi:10.1126/science.164.3878.444 · Cited by 1,380 · see citing works

Brain stem activation in spontaneous human migraine attacks

Weiller, C., May, A., Limmroth, V., Jüptner, M., Kaube, H., van Schayck, R., Coenen, H. H., & Dlener, H. C. (1995) · Nature Medicine · doi:10.1038/nm0795-658 · Cited by 1,379 · see citing works

The metabolic consequences of sleep deprivation

Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365 · see citing works

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, J., Kanarek, R. B., & Maratos–Flier, E. (1996) · Nature · doi:10.1038/380243a0 · Cited by 1,320 · see citing works

Calcitonin Gene-Related Peptide: Physiology and Pathophysiology

Russell, F. A., King, R., Smillie, S.-J., Kodji, X., & Brain, S. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00034.2013 · Cited by 1,278 · see citing works

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

Sakurai, T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2092 · Cited by 1,276 · see citing works

Starvation in Man

Sherwood, L. M., Parris, E. E., & Cahill, G. F. (1970) · New England Journal of Medicine · doi:10.1056/nejm197003192821209 · Cited by 1,253 · see citing works

Endogenous pain control mechanisms: Review and hypothesis

Basbaum, A. I., & Fields, H. L. (1978) · Annals of Neurology · doi:10.1002/ana.410040511 · Cited by 1,240 · see citing works

A putative flip–flop switch for control of REM sleep

Lu, J., Sherman, D. L., Devor, M. G., & Saper, C. B. (2006) · Nature · doi:10.1038/nature04767 · Cited by 1,219 · see citing works

Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model

Bolay, H., Reuter, U., Dunn, A. K., Huang, Z., Boas, D. A., & Moskowitz, M. A. (2002) · Nature Medicine · doi:10.1038/nm0202-136 · Cited by 1,214 · see citing works

Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

Olesen, J., Diener, H., Husstedt, I. W., Goadsby, P. J., Hall, D. B., Meier, U., Pollentier, S., & Lesko, L. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa030505 · Cited by 1,190 · see citing works

The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats

Goadsby, P. J., & Edvinsson, L. I. (1993) · Annals of Neurology · doi:10.1002/ana.410330109 · Cited by 1,164 · see citing works

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157 · see citing works

Pathophysiology of the migraine aura: The spreading depression theory

Lauritzen, M. (1994) · Brain · doi:10.1093/brain/117.1.199 · Cited by 1,151 · see citing works

Hypothalamic activation in cluster headache attacks

May, A., Bahra, A., Büchel, C., Frackowiak, R. S. J., & Goadsby, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02470-2 · Cited by 1,142 · see citing works

Cost of disorders of the brain in Europe

Andlin‐Sobocki, P., Jönsson, B., Wïttchen, H., & Olesen, J. (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2005.01202.x · Cited by 1,139 · see citing works

Mechanisms of Spreading Depression and Hypoxic Spreading Depression-Like Depolarization

Somjen, G. G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1065 · Cited by 1,124 · see citing works

Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society.

(1988) · PubMed · Cited by 1,055 · see citing works

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M., & Nakazato, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.748 · Cited by 1,050 · see citing works

Cgrp May Play A Causative Role in Migraine

Lassen, L., Haderslev, P. A., Jacobsen, V. B., Iversen, H. K., Sperling, B. K., & Olesen, J. (2002) · Cephalalgia · doi:10.1046/j.1468-2982.2002.00310.x · Cited by 1,029 · see citing works

Chronic pain and medullary descending facilitation

Porreca, F. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02157-4 · Cited by 1,007 · see citing works

Leptin Levels Are Dependent on Sleep Duration: Relationships with Sympathovagal Balance, Carbohydrate Regulation, Cortisol, and Thyrotropin

Spiegel, K., Leproult, R., L’Hermite-Balériaux, M., Copinschi, G., Penev, P. D., & Van Cauter, E. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-1003 · Cited by 1,006 · see citing works

Paraventricular Nucleus:A Site for the Integration of Neuroendocrine and Autonomic Mechanisms

Swanson, L. W., & Sawchenko, P. E. (2008) · Neuroendocrinology · doi:10.1159/000123111 · Cited by 1,001 · see citing works

Migraine as a Risk Factor for Subclinical Brain Lesions

Kruit, M. C. (2004) · JAMA · doi:10.1001/jama.291.4.427 · Cited by 992 · see citing works

Neurotransmitters in Nociceptive Modulatory Circuits

Fields, H. L., Heinricher, M. M., & Mason, P. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.001251 · Cited by 992 · see citing works

Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump α2 subunit associated with familial hemiplegic migraine type 2

Fusco, M. D., Marconi, R., Silvestri, L., Atorino, L., Rampoldi, L., Morgante, L., Ballabio, A., Aridon, P., & Casari, G. (2003) · Nature Genetics · doi:10.1038/ng1081 · Cited by 946 · see citing works

State-dependent opioid control of pain

Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946 · cited 1× · see citing works

FURTHER OBSERVATIONS ON THE SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

Leo, A. A. P. (1947) · Journal of Neurophysiology · doi:10.1152/jn.1947.10.6.409 · Cited by 943 · see citing works

Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice

Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K.-I., Sugiyama, F., Goto, K., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00331-3 · Cited by 936 · see citing works

The neurobiology of vascular head pain

Moskowitz, M. A. (1984) · Annals of Neurology · doi:10.1002/ana.410160202 · Cited by 913 · see citing works

New Appendix Criteria Open for a Broader Concept of Chronic Migraine

Olesen, J., Bousser, M.-G., Diener, H.-C., Dodick, D., First, M., Goadsby, P., Göbel, H., Lainez, M., Lance, J., Lipton, R., et al. (2006) · Cephalalgia · doi:10.1111/j.1468-2982.2006.01172.x · Cited by 909 · cited 1× · see citing works

Inadequate Sleep as a Risk Factor for Obesity: Analyses of the NHANES I

Gangwisch, J. E., Malaspina, D., Boden-Albala, B., & Heymsfield, S. B. (2005) · Sleep · doi:10.1093/sleep/28.10.1289 · Cited by 905 · see citing works

Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding

Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · see citing works

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879 · see citing works

Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

Lee, M., Hassani, O. K., & Jones, B. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1887-05.2005 · Cited by 870 · see citing works

Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system

Goadsby, P. J., Edvinsson, L. I., & Ekman, R. (1988) · Annals of Neurology · doi:10.1002/ana.410230214 · Cited by 865 · see citing works

Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome

Xu, Y., Padiath, Q. S., Shapiro, R. E., Jones, C. R., Wu, S. C., Saigoh, N., Saigoh, K., Ptáček, L. J., & Fu, Y.-H. (2005) · Nature · doi:10.1038/nature03453 · Cited by 861 · see citing works

Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine

Dichgans, M., Freilinger, T. M., Eckstein, G., Babini, E., Lorenz‐Depiereux, B., Biskup, S., Ferrari, M. D., Herzog, J., van den Maagdenberg, A. M. J. M., Pusch, M., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66786-4 · Cited by 852 · see citing works

Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraine

Olesen, J., Larsen, B., & Lauritzen, M. (1981) · Annals of Neurology · doi:10.1002/ana.410090406 · Cited by 849 · see citing works

Migraine and cardiovascular disease: systematic review and meta-analysis

Schürks, M., Rist, P. M., Bigal, M., Buring, J. E., Lipton, R. B., & Kurth, T. (2009) · BMJ · doi:10.1136/bmj.b3914 · Cited by 839 · see citing works

Anatomy of the human body

Gray, H., Gray, H., & Lewis, W. H. (1918) · Lea & Febiger eBooks · doi:10.5962/bhl.title.20311 · Cited by 839 · see citing works

Headache and Other Head Pain

(1949) · Physical Therapy · doi:10.1093/ptj/29.4.190c · Cited by 800 · see citing works

EXPERIMENTAL STUDIES ON HEADACHE

Ray, B. S. (1940) · Archives of Surgery · doi:10.1001/archsurg.1940.01210040002001 · Cited by 788 · see citing works

Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.

Sinha, M. K., Ohannesian, J. P., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Magosin, S., Marco, C. C., & Caro, J. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118551 · Cited by 785 · see citing works

Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury

Lauritzen, M., Dreier, J. P., Fabricius, M., Hartings, J. A., Graf, R., & Strong, A. J. (2011) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2010.191 · Cited by 782 · see citing works

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors

Kobayashi, K., Fukuoka, T., Obata, K., Yamanaka, H., Dai, Y., Tokunaga, A., & Noguchi, K. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20794 · Cited by 766 · see citing works

The development of cutaneous allodynia during a migraine attack Clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine

Burstein, R. (2000) · Brain · doi:10.1093/brain/123.8.1703 · Cited by 765 · see citing works

Intrinsic Fluctuations within Cortical Systems Account for Intertrial Variability in Human Behavior

Fox, M., Snyder, A. Z., Vincent, J. L., & Raichle, M. E. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.023 · Cited by 753 · see citing works

Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior.

Stanley, B. G., & LEIBOWITZ, S. F. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3940 · Cited by 741 · see citing works

A review of paroxysmal hemicranias, SUNCT syndrome and other short- lasting headaches with autonomic feature, including new cases

Goadsby, P. J. (1997) · Brain · doi:10.1093/brain/120.1.193 · Cited by 732 · see citing works

Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus

Cunningham, E. T., & Sawchenko, P. E. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902740107 · Cited by 727 · see citing works

Sensitization of meningeal sensory neurons and the origin of headaches

Strassman, A. M., Raymond, S. A., & Burstein, R. (1996) · Nature · doi:10.1038/384560a0 · Cited by 704 · see citing works

Neuropeptide Y distribution in human brain

Adrian, T. E., Allen, J. M., Bloom, S. R., Ghatei, M. A., Rossor, M. N., Roberts, G. W., Crow, T. J., Tatemoto, K., & Polak, J. M. (1983) · Nature · doi:10.1038/306584a0 · Cited by 701 · see citing works

A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression

van den Maagdenberg, A. M. J. M., Pietrobon, D., Pizzorusso, T., Kaja, S., Broos, L. A. M., Cesetti, T., van de Ven, R. C. G., Tottene, A., van der Kaa, J., Plomp, J. J., et al. (2004) · Neuron · doi:10.1016/s0896-6273(04)00085-6 · Cited by 692 · see citing works

Human in vivo evidence for trigeminovascular activation in cluster headache Neuropeptide changes and effects of acute attacks therapies

Goadsby, P. J., & Edvinsson, L. I. (1994) · Brain · doi:10.1093/brain/117.3.427 · Cited by 683 · see citing works

A Manual of Diseases of the Nervous System.

(1892) · JAMA · doi:10.1001/jama.1892.02420130030009 · Cited by 679 · see citing works

Efferent projections of the suprachiasmatic nucleus: I. Studies using anterograde transport of Phaseolus vulgaris leucoagglutinin in the rat

Watts, A. G., Swanson, L. W., & Sanchez‐Watts, G. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902580204 · Cited by 678 · see citing works

The Association Between Short Sleep Duration and Obesity in Young Adults: a 13-Year Prospective Study

Hasler, G., Buysse, D. J., Klaghofer, R., Gamma, A., Ajdacic, V., Eich, D., Rössler, W., & Angst, J. (2004) · Sleep · doi:10.1093/sleep/27.4.661 · Cited by 672 · see citing works

Premonitory symptoms in migraine

Giffin, N., Ruggiero, L., Lipton, R. B., Silberstein, S. D., Tvedskov, J. F., Olesen, J., Altman, J. S., Goadsby, P. J., & Macrae, A. (2003) · Neurology · doi:10.1212/01.wnl.0000052998.58526.a9 · Cited by 671 · see citing works

Migraine Headache Triggered Specifically by Sunlight: Report of 16 Cases

Tekataş, A., & Mungen, B. (2013) · European Neurology · doi:10.1159/000354165 · Cited by 665 · see citing works

Neuroreptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus

Stanley, B. G., & LEIBOWITZ, S. F. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90032-8 · Cited by 665 · see citing works

Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

Kalra, S. P., Dubé, M., Sahu, A., Phelps, C. P., & Kalra, P. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10931 · Cited by 665 · see citing works

Selective deletion of leptin receptor in neurons leads to obesity

Cohen, P., Zhao, C., Cai, X., Montez, J. M., Rohani, S., Feinstein, P. G., Mombaerts, P., & Friedman, J. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13914 · Cited by 657 · see citing works

Fos Expression in Orexin Neurons Varies with Behavioral State

Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B., & Scammell, T. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01656.2001 · Cited by 654 · see citing works

Leptin Regulation of the Mesoaccumbens Dopamine Pathway

Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.006 · Cited by 644 · see citing works

Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats

Brady, L. S., Smith, M. A., Gold, P. W., & Herkenham, M. A. (2008) · Neuroendocrinology · doi:10.1159/000125626 · Cited by 641 · see citing works

Migraine With Aura and Migraine Without Aura: An Epidemiological Study

Rasmussen, B. K., & Olesen, J. (1992) · Cephalalgia · doi:10.1046/j.1468-2982.1992.1204221.x · Cited by 629 · see citing works

Pain processing during three levels of noxious stimulation produces differential patterns of central activity

Derbyshire, S. W. G., Jones, A. K. P., Gyulai, F., Clark, S., Townsend, D., & Firestone, L. L. (1997) · Pain · doi:10.1016/s0304-3959(97)00138-3 · Cited by 629 · see citing works

Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers

Buse, D. C., Manack, A., Serrano, D., Turkel, C., & Lipton, R. B. (2010) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp.2009.192492 · Cited by 622 · see citing works

Periaqueductal Gray Matter Dysfunction in Migraine: Cause or the Burden of Illness?

Welch, K. M. A., Nagesh, V., Aurora, S. K., & Gelman, N. (2001) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2001.041007629.x · Cited by 621 · see citing works

The NPY system in stress, anxiety and depression

Heilig, M. A. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.002 · Cited by 617 · see citing works

Brainstem activation specific to migraine headache

Bahra, A., Matharu, M. S., Büchel, C., Frackowiak, R. S. J., & Goadsby, P. J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04250-1 · Cited by 608 · see citing works

Chemical Stimulation of the Intracranial Dura Induces Enhanced Responses to Facial Stimulation in Brain Stem Trigeminal Neurons

Burstein, R., Yamamura, H., Malick, A., & Strassman, A. M. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.964 · Cited by 607 · see citing works

Defeating migraine pain with triptans: A race against the development of cutaneous allodynia

Burstein, R., Collins, B., & Jakubowski, M. (2003) · Annals of Neurology · doi:10.1002/ana.10786 · Cited by 605 · see citing works

Cutaneous allodynia in the migraine population

Lipton, R. B., BIGAL, M. E., Ashina, S., Burstein, R., Silberstein, S. D., Reed, M. L., Serrano, D., Stewart, W. F., & American Migraine Prevalence Prevention Advisory Group (2007) · Annals of Neurology · doi:10.1002/ana.21211 · Cited by 603 · see citing works

Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels

Westenbroek, R. E., Sakurai, T., Elliott, E. M., Hell, J., Starr, T., Snutch, T., & Catterall, W. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06403.1995 · Cited by 594 · see citing works

The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks

Schulte, L. H., & May, A. (2016) · Brain · doi:10.1093/brain/aww097 · Cited by 586 · see citing works

The Trigeminovascular System in Humans: Pathophysiologic Implications for Primary Headache Syndromes of the Neural Influences on the Cerebral Circulation

May, A., & Goadsby, P. J. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199902000-00001 · Cited by 583 · see citing works

OBSERVATIONS ON 500 CASES OF MIGRAINE AND ALLIED VASCULAR HEADACHE

Selby, G., & Lance, J. W. (1960) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.23 · Cited by 580 · see citing works

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

Katona, I., & Freund, T. F. (2008) · Nature Medicine · doi:10.1038/nm.f.1869 · Cited by 579 · see citing works

Limbic Regulation of Hypothalamo‐Pituitary‐Adrenocortical Function during Acute and Chronic Stress

Jankord, R., & Herman, J. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.012 · Cited by 578 · see citing works

Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms

Chou, T. C., Scammell, T. E., Gooley, J. J., Gaus, S. E., Saper, C. B., & Lu, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10691.2003 · Cited by 576 · see citing works

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with Aδ/C-fibers and colocalization with Trk receptors

小林, 希. (2007) · Medical Entomology and Zoology · Cited by 575 · see citing works

Classification and nomenclature of somatostatin receptors

Hoyer, D., Bell, G. I., Berelowitz, M., Epelbaum, J., Feniuk, W., Humphrey, P. P. A., O'Carroll, A.-M., Patel, Y., Schönbrunn, A., Taylor, J. E., et al. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)88988-9 · Cited by 572 · see citing works

Suppression of cortical spreading depression in migraine prophylaxis

Ayata, C., Jin, H., Kudo, C., Dalkara, T., & Moskowitz, M. A. (2006) · Annals of Neurology · doi:10.1002/ana.20778 · Cited by 571 · see citing works

A neural mechanism for exacerbation of headache by light

Noseda, R., Kainz, V., Jakubowski, M., Gooley, J. J., Saper, C. B., Digre, K., & Burstein, R. (2010) · Nature Neuroscience · doi:10.1038/nn.2475 · Cited by 565 · see citing works

The Anatomy of Brain Stem Pathways to the Spinal Cord in Cat. A Labeled Amino Acid Tracing Study

Holstege, G., & Kuypers, H. G. J. M. (1982) · Progress in brain research · doi:10.1016/s0079-6123(08)64128-x · Cited by 559 · see citing works

A multisensory investigation of the functional significance of the “pain matrix”

Mouraux, A., Diukova, A., Lee, M., Wise, R. G., & Iannetti, G. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.084 · Cited by 556 · see citing works

CORTICOBULBAR CONNEXIONS TO THE PONS AND LOWER BRAIN-STEM IN MAN

Kuypers, H. G. J. M. (1958) · Brain · doi:10.1093/brain/81.3.364 · Cited by 556 · see citing works

Selective deletion of leptin receptor in neurons leads to obesity

Cohen, P., Zhao, C., Cai, X., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113914 · Cited by 554 · see citing works

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

Dupuis, L., Corcia, P., Fergani, A., de Aguilar, J. G., Bonnefont‐Rousselot, D., Bittar, R., Seilhean, D., Hauw, J., Lacomblez, L., Loeffler, J.-P., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000285080.70324.27 · Cited by 551 · see citing works

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

Frederich, R. C., Löllmann, B., Hamann, A., Napolitano-Rosen, A., Kahn, B. B., Lowell, B. B., & Flier, J. S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118206 · Cited by 549 · see citing works

Effectiveness of high‐dose riboflavin in migraine prophylaxis A randomized controlled trial

Schoenen, J., Jacquy, J., & Lenaerts, M. (1998) · Neurology · doi:10.1212/wnl.50.2.466 · Cited by 548 · see citing works

Correlation between structural and functional changes in brain in an idiopathic headache syndrome

May, A., Ashburner, J., Büchel, C., McGonigle, D. J., Friston, K. J., Frackowiak, R. S. J., & Goadsby, P. J. (1999) · Nature Medicine · doi:10.1038/10561 · Cited by 547 · see citing works

Organization of projections from the ventromedial nucleus of the hypothalamus: A Phaseolus vulgaris ‐Leucoagglutinin study in the rat

Canteras, N. S., Simerly, R. B., & Swanson, L. W. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903480103 · Cited by 547 · see citing works

Alzheimer's β-Amyloid Peptides Compete for Insulin Binding to the Insulin Receptor

Xie, L., Helmerhorst, E., Taddei, K., Plewright, B., van Bronswijk, W., & Martins, R. N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-j0001.2002 · Cited by 542 · see citing works

Diencephalic and brainstem mechanisms in migraine

Akerman, S., Holland, P. R., & Goadsby, P. J. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3057 · Cited by 535 · see citing works

Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

Ho, T. W., Ferrari, M. D., Dodick, D. W., Galet, V. A., Kost, J. T., Fan, X. F., Leibensperger, H., Froman, S., Assaid, C. A., Lines, C., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61626-8 · Cited by 533 · see citing works

MECHANISM OF MIGRAINE HEADACHE AND ACTION OF ERGOTAMINE TARTRATE

Graham, J. R. (1938) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1938.02270040093005 · Cited by 525 · see citing works

An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat

Bai, F.-L., Yamano, M., Shiotani, Y., Emson, P. C., Smith, A. D., Powell, J. F., & Tohyama, M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90730-9 · Cited by 524 · see citing works

Hypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord

van den Pol, A. N. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-03171.1999 · Cited by 524 · see citing works

CGRP and its receptors provide new insights into migraine pathophysiology

Ho, T. W., Edvinsson, L. I., & Goadsby, P. J. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.127 · Cited by 522 · see citing works

PATTERNS OF CEREBRAL INTEGRATION INDICATED BY THE SCOTOMAS OF MIGRAINE

Lashley, K. S. (1941) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1941.02280200137007 · Cited by 520 · see citing works

The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat

Fields, H. L., Bry, J., Hentall, I. D., & Zorman, G. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-12-02545.1983 · Cited by 518 · see citing works

Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves

Kolaczynski, J. W., Considine, R. V., Ohannesian, J. P., Marco, C. C., Opentanova, I., Nyce, M. R., Myint, M., & Caro, J. F. (1996) · Diabetes · doi:10.2337/diab.45.11.1511 · Cited by 517 · see citing works

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

Karataş, H., Erdener, Ş. E., Özdemir, Y., Lüle, S., Eren‐Koçak, E., Şen, Z. D., & Dalkara, T. (2013) · Science · doi:10.1126/science.1231897 · Cited by 516 · see citing works

Neuroanatomical Localization, Pharmacological Characterization and Functions of CGRP, Related Peptides and Their Receptors

van Rossum, D., Hanisch, U., & Quirion, R. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00023-1 · Cited by 512 · see citing works

Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons

Bourgin, P., Huitrón‐Reséndiz, S., Spier, A. D., Fabre, V., Morte, B., Criado, J. R., Sutcliffe, J. G., Henriksen, S. J., & de Lecea, L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07760.2000 · Cited by 508 · see citing works

Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus

Sahu, A., Kalra, P. S., & Kalra, S. P. (1988) · Peptides · doi:10.1016/0196-9781(88)90013-7 · Cited by 503 · see citing works

Short sleep duration is associated with reduced leptin levels and increased adiposity: Results from the Quebec family study.

Chaput, J., Després, J., Bouchard, C., & Tremblay, A. (2007) · Obesity · doi:10.1038/oby.2007.512 · Cited by 498 · see citing works

Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks

Maniyar, F., Sprenger, T., Monteith, T., Schankin, C. J., & Goadsby, P. J. (2013) · Brain · doi:10.1093/brain/awt320 · Cited by 497 · see citing works

The locus coeruleus: neurobiology of a central noradrenergic nucleus

Amaral, D. G., & Sinnamon, H. M. (1977) · Progress in Neurobiology · doi:10.1016/0301-0082(77)90016-8 · Cited by 495 · see citing works

PACAP38 induces migraine-like attacks in patients with migraine without aura

Schytz, H. W., Birk, S., Wienecke, T., Kruuse, C. R., Olesen, J., & Ashina, M. (2008) · Brain · doi:10.1093/brain/awn307 · Cited by 494 · see citing works

Leptin targets in the mouse brain

Scott, M. M., Lachey, J. L., Sternson, S. M., Lee, C. E., Elias, C. F., Friedman, J. M., & Elmquist, J. K. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.22025 · Cited by 484 · see citing works

Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

Hansen, J. M., Hauge, A. W., Olesen, J., & Ashina, M. (2010) · Cephalalgia · doi:10.1177/0333102410368444 · Cited by 483 · see citing works

Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons

Fields, H. L., Basbaum, A. I., Clanton, C. H., & Anderson, S. D. (1977) · Brain Research · doi:10.1016/0006-8993(77)90596-0 · Cited by 476 · see citing works

Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input

Bartsch, T. (2002) · Brain · doi:10.1093/brain/awf166 · Cited by 475 · see citing works

Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist

Doods, H. N., Hallermayer, G., Wu, D., Entzeroth, M., Rudolf, K. D., Engel, W. W., & Eberlein, W. G. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703110 · Cited by 466 · see citing works

Restless legs syndrome: Revisiting the dopamine hypothesis from the spinal cord perspective

Clemens, S., Rye, D., & Hochman, S. (2006) · Neurology · doi:10.1212/01.wnl.0000223316.53428.c9 · Cited by 465 · see citing works

Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial

Lipton, R. B., Dodick, D. W., Silberstein, S. D., Saper, J. R., Aurora, S. K., Pearlman, S. H., Fischell, R. E., Ruppel, P. L., & Goadsby, P. J. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70054-5 · Cited by 465 · see citing works

Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine

Ho, T. W., Mannix, L. K., Fan, X. F., Assaid, C., Furtek, C. I., Jones, C. J., Lines, C. R., & Rapoport, A. M. (2007) · Neurology · doi:10.1212/01.wnl.0000286940.29755.61 · Cited by 464 · see citing works

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A. J., Sakurai, T., Kilduff, T. S., Horvath, T. L., & de Lecea, L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3459-04.2004 · Cited by 462 · see citing works

Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater

Bartsch, T. (2003) · Brain · doi:10.1093/brain/awg190 · Cited by 459 · see citing works

Identification of Wake-Active Dopaminergic Neurons in the Ventral Periaqueductal Gray Matter

Lu, J., Jhou, T. C., & Saper, C. B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2244-05.2006 · Cited by 458 · see citing works

Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research

Arimura, A. (1992) · Regulatory Peptides · doi:10.1016/0167-0115(92)90621-z · Cited by 456 · see citing works

Leptin Inhibition of the Hypothalamic-Pituitary-Adrenal Axis in Response to Stress 1

Heiman, M. L., Ahima, R. S., Craft, L. S., Schoner, B. E., Stephens, T. W., & Flier, J. S. (1997) · Endocrinology · doi:10.1210/endo.138.9.5366 · Cited by 454 · see citing works

A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep

Verret, L., Goutagny, R., Fort, P., Cagnon, L., Salvert, D., Léger, L., Boissard, R., Salin, P. A., Peyron, C., & Luppi, P. (2003) · BMC Neuroscience · doi:10.1186/1471-2202-4-19 · Cited by 453 · see citing works

A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate

Afridi, S. K. (2005) · Brain · doi:10.1093/brain/awh416 · Cited by 453 · see citing works

The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms

Gooley, J. J., Schomer, A., & Saper, C. B. (2006) · Nature Neuroscience · doi:10.1038/nn1651 · Cited by 453 · see citing works

Cumulative Lifetime Migraine Incidence in Women and Men

Stewart, W., Wood, C., Reed, M. L., Roy, J., & Lipton, R. B. (2008) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01666.x · Cited by 451 · see citing works

Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain

Markowitz, S., Saito, K., & Moskowitz, M. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-12-04129.1987 · Cited by 441 · see citing works

Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem

Elmquist, J. K., Ahima, R. S., Maratos–Flier, E., Flier, J. S., & Saper, C. B. (1997) · Endocrinology · doi:10.1210/endo.138.2.5033 · Cited by 438 · see citing works

Spreading and Synchronous Depressions of Cortical Activity in Acutely Injured Human Brain

Strong, A. J., Fabricius, M. E., Boutelle, M. G., Hibbins, S. J., Hopwood, S. E., Jones, R., Parkin, M. C., & Lauritzen, M. (2002) · Stroke · doi:10.1161/01.str.0000043073.69602.09 · Cited by 438 · see citing works

Pain modulation: expectation, opioid analgesia and virtual pain

Fields, H. L. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62143-3 · Cited by 433 · see citing works

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

Edwards, C., Abusnana, S., Sunter, D., Murphy, K. G., Ghatei, M. A., & Bloom, S. R. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.160r007 · Cited by 433 · see citing works

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Chasman, D. I., Schürks, M., Anttila, V., de Vries, B., Schminke, U., Launer, L. J., Terwindt, G. M., van den Maagdenberg, A. M. J. M., Fendrich, K., Völzke, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.856 · Cited by 431 · see citing works

Pathophysiology of cluster headache: a trigeminal autonomic cephalgia

Goadsby, P. J. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00104-7 · Cited by 429 · see citing works

Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study

Saper, J. R., Dodick, D. W., Silberstein, S. D., McCarville, S., Sun, M., & Goadsby, P. J. (2010) · Cephalalgia · doi:10.1177/0333102410381142 · Cited by 429 · see citing works

Hypothalamic Activation in Spontaneous Migraine Attacks

Denuelle, M., Fabre, N., Payoux, P., Chollet, F., & Geraud, G. E. A. (2007) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2007.00776.x · Cited by 423 · see citing works

Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex

Fabricius, M., Fuhr, S., Bhatia, R., Boutelle, M., Hashemi, P., Strong, A. J., & Lauritzen, M. (2006) · Brain · doi:10.1093/brain/awh716 · Cited by 420 · see citing works

Genetic approaches to studying energy balance: perception and integration

Barsh, G. S., & Schwartz, M. W. (2002) · Nature Reviews Genetics · doi:10.1038/nrg862 · Cited by 417 · see citing works

A Positron Emission Tomographic Study in Spontaneous Migraine

Afridi, S. K., Giffin, N., Kaube, H., Friston, K. J., Ward, N., Frackowiak, R. S. J., & Goadsby, P. J. (2005) · Archives of Neurology · doi:10.1001/archneur.62.8.1270 · Cited by 417 · see citing works

The hypocretins: Setting the arousal threshold

Sutcliffe, J. G., & de Lecea, L. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn808 · Cited by 416 · see citing works

The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater

Buzzi, M. G., & Moskowitz, M. A. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14679.x · Cited by 415 · see citing works

Regional distribution of Y‐receptor subtype mRNAs in rat brain

Parker, R. M. C., & Herzog, H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00553.x · Cited by 412 · see citing works

Genome-wide meta-analysis identifies new susceptibility loci for migraine

North American Brain Expression Consortium, Anttila, V., UK Brain Expression Consortium, the International Headache Genetics Consortium, Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., et al. (2013) · Nature Genetics · doi:10.1038/ng.2676 · Cited by 410 · see citing works

Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: Trigeminal origin and co-existence with substance P

Uddman, R., Edvinsson, L. I., Ekman, R., Kingman, T. A., & McCulloch, J. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90296-4 · Cited by 409 · see citing works

Thalamic sensitization transforms localized pain into widespread allodynia

Burstein, R., Jakubowski, M., Garcia-Nicas, E., Kainz, V., Bajwa, Z. H., Hargreaves, R., Becerra, L. R., & Borsook, D. (2010) · Annals of Neurology · doi:10.1002/ana.21994 · Cited by 408 · see citing works

Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura

Zhang, X., Levy, D., Noseda, R., Kainz, V., Jakubowski, M., & Burstein, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0511-10.2010 · Cited by 408 · see citing works

Mechanism and Management of Headache

(2005) · Elsevier eBooks · doi:10.1016/b978-0-7506-7530-7.x5001-4 · Cited by 406 · see citing works

Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2

Xu, Y., Toh, K. L., Jones, C. R., Shin, J., Fu, Y., & Ptáček, L. J. (2007) · Cell · doi:10.1016/j.cell.2006.11.043 · Cited by 405 · see citing works

Overweight and obese patients in a primary care population report less sleep than patients with a normal body mass index

Vorona, R. D., Winn, M. P., Babineau, T. W., Eng, B. P., Feldman, H. R., & Ware, J. C. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.1.25 · Cited by 405 · see citing works

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1

Anttila, V., Calafato, M., Dimas, A. S., Inouye, M., Alakurtti, K., Hämäläinen, E., Barrett, J. C., Peltonen, L., Palotie, A. V., Kaunisto, M. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.652 · Cited by 404 · see citing works

Activation of central trigeminovascular neurons by cortical spreading depression

Zhang, X., Levy, D., Kainz, V., Noseda, R., Jakubowski, M., & Burstein, R. (2010) · Annals of Neurology · doi:10.1002/ana.22329 · Cited by 400 · see citing works

CGRP as the target of new migraine therapies — successful translation from bench to clinic

Edvinsson, L. I., Haanes, K. A., Warfvinge, K., & Krause, D. N. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0003-1 · Cited by 1,010 · see citing works

The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders

Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works

Fremanezumab for the Preventive Treatment of Chronic Migraine

Silberstein, S. D., Dodick, D. W., BIGAL, M. E., Yeung, P. P., Goadsby, P. J., Blankenbiller, T., Grozinski‐Wolff, M., Yang, R., Ma, Y., & Aycardi, E. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1709038 · Cited by 794 · see citing works

Effect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine

Dodick, D. W., Silberstein, S. D., BIGAL, M. E., Yeung, P. P., Goadsby, P. J., Blankenbiller, T., Grozinski‐Wolff, M., Yang, R., Ma, Y., & Aycardi, E. (2018) · JAMA · doi:10.1001/jama.2018.4853 · Cited by 563 · see citing works

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

Fiorentini, D., Cappadone, C., Farruggia, G., & Prata, C. (2021) · Nutrients · doi:10.3390/nu13041136 · Cited by 598 · see citing works

Migraine

Dodick, D. W. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30478-1 · Cited by 562 · see citing works

Efficacy and safety of galcanezumab for the prevention of episodic migraine: Results of the EVOLVE-2 Phase 3 randomized controlled clinical trial

Skljarevski, V., Matharu, M. S., Millen, B. A., Ossipov, M. H., Kim, B., & Yang, J. Y. (2018) · Cephalalgia · doi:10.1177/0333102418779543 · Cited by 532 · see citing works

A Phase‐by‐Phase Review of Migraine Pathophysiology

Dodick, D. W. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13300 · Cited by 511 · see citing works

Migraine

Ferrari, M. D., Goadsby, P. J., Burstein, R., Kurth, T., Ayata, C., Charles, A. C., Ashina, M., van den Maagdenberg, A. M. J. M., & Dodick, D. W. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00328-4 · Cited by 509 · see citing works

Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

Davis, K. D., Aghaeepour, N., Ahn, A. H., Angst, M. S., Borsook, D., Brenton, A., Burczynski, M. E., Crean, C. S., Edwards, R. R., Gaudilliere, B. L., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0362-2 · Cited by 499 · see citing works

CGRP and the Trigeminal System in Migraine

Iyengar, S., Johnson, K. W., Ossipov, M. H., & Aurora, S. K. (2019) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13529 · Cited by 491 · see citing works

Headaches Associated With Personal Protective Equipment – A Cross‐Sectional Study Among Frontline Healthcare Workers During COVID‐19

Ong, J. J. Y., Chandra, B., Goh, Y., Tang, J. Z. Y., Sooi, K. W. X., Tan, Y. L., Tan, B. Y., Teoh, H., Ong, S. T., Allen, D. M., et al. (2020) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13811 · Cited by 463 · see citing works

Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised, phase 3, double-blind, placebo-controlled trial

Croop, R. S., Goadsby, P. J., Stock, D. A., Conway, C. M., Forshaw, M., Stock, E. G., Coric, V., & Lipton, R. B. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31606-x · Cited by 406 · see citing works

Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine

Lipton, R. B., Croop, R. S., Stock, E. G., Stock, D. A., Morris, B. A., Frost, M., Dubowchik, G. M., Conway, C. M., Coric, V., & Goadsby, P. J. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1811090 · Cited by 406 · see citing works

Functional Near-Infrared Spectroscopy and Its Clinical Application in the Field of Neuroscience: Advances and Future Directions

Chen, W.-L., Wagner, J. C., Heugel, N., Sugar, J., Lee, Y.-W., Conant, L. L., Malloy, M., Heffernan, J., Quirk, B. J., Zinos, A., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00724 · Cited by 390 · see citing works

Migraine: disease characterisation, biomarkers, and precision medicine

Ashina, M., Terwindt, G. M., Al‐Karagholi, M. A., de Boer, I., Lee, M. J., Hay, D. L., Schulte, L. H., Hadjikhani, N. K., Sinclair, A. J., Ashina, H., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32162-0 · Cited by 382 · see citing works

The Role of Magnesium in Neurological Disorders

Kirkland, A. E., Sarlo, G. L., & Holton, K. F. (2018) · Nutrients · doi:10.3390/nu10060730 · Cited by 382 · see citing works

Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial

Croop, R. S., Lipton, R. B., Kudrow, D., Stock, D. A., Kamen, L., Conway, C. M., Stock, E. G., Coric, V., & Goadsby, P. J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32544-7 · Cited by 363 · see citing works

Ubrogepant for the Treatment of Migraine

Dodick, D. W., Lipton, R. B., Ailani, J., Lu, K., Finnegan, M., Trugman, J. M., & Szegedi, A. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1813049 · Cited by 361 · see citing works

Does inflammation have a role in migraine?

Edvinsson, L. I., Haanes, K. A., & Warfvinge, K. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0216-y · Cited by 312 · see citing works

T he T rigeminovascular P athway: R ole of CGRP and CGRP R eceptors in M igraine

Edvinsson, L. I. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13081 · Cited by 298 · see citing works

Diagnosis, pathophysiology, and management of cluster headache

Hoffmann, J., & May, A. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30405-2 · Cited by 290 · see citing works

Phase 3 randomized, placebo-controlled, double-blind study of lasmiditan for acute treatment of migraine

Goadsby, P. J., Wietecha, L. A., Dennehy, E. B., Kuca, B., Case, M. G., Aurora, S. K., & Gaul, C. (2019) · Brain · doi:10.1093/brain/awz134 · Cited by 274 · see citing works

Migraine and neuroinflammation: the inflammasome perspective

Kurşun, O., Yemisci, M., van den Maagdenberg, A. M., & Karatas, H. (2021) · The Journal of Headache and Pain · doi:10.1186/s10194-021-01271-1 · Cited by 209 · see citing works

COVID‐19 is a Real Headache!

Bolay, H., Gül, A., & Baykan, B. B. (2020) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13856 · Cited by 257 · see citing works

Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine

Khan, J., Asoom, L. I. A., Alsunni, A. A., Rafique, N., Latif, R., Saif, S. A., Almandil, N. B., Almohazey, D., AbdulAzeez, S., & Borgio, J. F. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111557 · Cited by 241 · see citing works

Advances in genetics of migraine

Sutherland, H. G. E., Albury, C. L., & Griffiths, L. R. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-1017-9 · Cited by 238 · see citing works

Safety, tolerability, and efficacy of orally administered atogepant for the prevention of episodic migraine in adults: a double-blind, randomised phase 2b/3 trial

Goadsby, P. J., Dodick, D. W., Ailani, J., Trugman, J. M., Finnegan, M., Lu, K., & Szegedi, A. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30234-9 · Cited by 230 · see citing works

Diagnosis and Management of Headache

Robbins, M. S. (2021) · JAMA · doi:10.1001/jama.2021.1640 · Cited by 227 · see citing works

Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting

Wattiez, A., Sowers, L. P., & Russo, A. F. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1724285 · Cited by 221 · see citing works

Migraine Treatment: Current Acute Medications and Their Potential Mechanisms of Action

Ong, J. J. Y., & Felice, M. D. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0592-1 · Cited by 213 · see citing works

Mechanism of Action of OnabotulinumtoxinA in Chronic Migraine: A Narrative Review

Burstein, R., Blumenfeld, A. M., Silberstein, S. D., Adams, A. M., & Brin, M. F. (2020) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13849 · Cited by 210 · see citing works

Biological insights from the premonitory symptoms of migraine

Karsan, N., & Goadsby, P. J. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0098-4 · Cited by 196 · see citing works

Behavioral and cognitive animal models in headache research

Vurallı, D., Wattiez, A., Russo, A. F., & Bolay, H. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-0963-6 · Cited by 192 · see citing works

Migraine: from pathophysiology to treatment

Puledda, F., Silva, E., Suwanlaong, K., & Goadsby, P. J. (2023) · Journal of Neurology · doi:10.1007/s00415-023-11706-1 · Cited by 191 · see citing works

Current and emerging evidence-based treatment options in chronic migraine: a narrative review

The Italian chronic migraine group, Agostoni, E. C., Barbanti, P., Calabresi, P., Colombo, B., Cortelli, P., Frediani, F., Geppetti, P., Grazzi, L., Leone, M., et al. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-1038-4 · Cited by 181 · see citing works

Phenotypic features of central sensitization

Williams, D. A. (2018) · Journal of Applied Biobehavioral Research · doi:10.1111/jabr.12135 · Cited by 180 · see citing works

Pathophysiology of Migraine

Goadsby, P. J., & Holland, P. R. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.07.008 · Cited by 170 · see citing works

Vestibular migraine: An update on current understanding and future directions

Huang, T.-C., Wang, S., & Kheradmand, A. (2019) · Cephalalgia · doi:10.1177/0333102419869317 · Cited by 168 · see citing works

Glutamate and Its Receptors as Therapeutic Targets for Migraine

Hoffmann, J., & Charles, A. C. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0616-5 · Cited by 166 · see citing works

Anti-CGRP Monoclonal Antibodies: the Next Era of Migraine Prevention?

Tso, A. R., & Goadsby, P. J. (2017) · Current Treatment Options in Neurology · doi:10.1007/s11940-017-0463-4 · Cited by 163 · see citing works

Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

Logu, F. D., Nassini, R., Hégron, A., Landini, L., Jensen, D. D., Latorre, R., Ding, J. H., Marini, M., de Araújo, D. S. M., Ramírez-García, P. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28204-z · Cited by 161 · see citing works

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

Spekker, E., Tanaka, M., Szabó, Á., & Vécsei, L. (2021) · Biomedicines · doi:10.3390/biomedicines10010076 · Cited by 164 · see citing works

Gepants for the treatment of migraine

Negro, A., & Martelletti, P. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1618830 · Cited by 156 · see citing works

Eptinezumab for prevention of chronic migraine: A randomized phase 2b clinical trial

Dodick, D. W., Lipton, R. B., Silberstein, S. D., Goadsby, P. J., Biondi, D. M., Hirman, J., Cady, R. K., & Smith, J. (2019) · Cephalalgia · doi:10.1177/0333102419858355 · Cited by 155 · see citing works

From transformation to chronification of migraine: pathophysiological and clinical aspects

Torres‐Ferrús, M., Ursitti, F., Alpuente, A., Brunello, F., Chiappino, D., de Vries, T., Marco, S. D., Ferlisi, S., Guerritore, L., González-García, N., et al. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01111-8 · Cited by 152 · see citing works

An update on migraine: current understanding and future directions

Puledda, F., Messina, R., & Goadsby, P. J. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8434-y · Cited by 150 · see citing works

Lasmiditan mechanism of action – review of a selective 5-HT1F agonist

Clemow, D. B., Johnson, K. W., Hochstetler, H. M., Ossipov, M. H., Hake, A. M., & Blumenfeld, A. M. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01132-3 · Cited by 145 · see citing works

Chronic migraine: A process of dysmodulation and sensitization

Su, M., & Yu, S. (2018) · Molecular Pain · doi:10.1177/1744806918767697 · Cited by 144 · see citing works

Role of CGRP in Migraine

Edvinsson, L. I. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2018_201 · Cited by 143 · see citing works

The fifth cranial nerve in headaches

Edvinsson, J. C. A., Viganò, A., Alekseeva, A., Alieva, E., Arruda, R., Luca, C. D., D’Ettore, N., Frattale, I., Kurnukhina, M. Y., Macerola, N., et al. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01134-1 · Cited by 139 · see citing works

Neurovascular mechanisms of migraine and cluster headache

Hoffmann, J., Baca, S. M., & Akerman, S. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17733655 · Cited by 138 · see citing works

Transcutaneous auricular vagus nerve stimulation (taVNS) for migraine: an fMRI study

Zhang, Y., Huang, Y., Li, H., Yan, Z., Zhang, Y., Liu, X., Hou, X., Chen, W., Tu, Y., Hodges, S., et al. (2020) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2020-102088 · Cited by 138 · see citing works

Targeted Nitric Oxide Synthase Inhibitors for Migraine

Pradhan, A. A. A., Bertels, Z., & Akerman, S. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0614-7 · Cited by 137 · see citing works

CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?

Favoni, V., Giani, L., Al‐Hassany, L., Asioli, G. M., Butera, C., de Boer, I., Guglielmetti, M., Koniari, C., Mavridis, T., Vaikjärv, M., et al. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-0979-y · Cited by 137 · see citing works

Imaging of neuroinflammation in migraine with aura

Albrecht, D., Mainero, C., Ichijo, E., Ward, N., Granziera, C., Zürcher, N. R., Akeju, O., Bonnier, G., Price, J. C., Hooker, J. M., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007371 · Cited by 134 · see citing works

Longitudinal Neuroimaging over 30 Days: Temporal Characteristics of Migraine

Schulte, L. H., Mehnert, J., & May, A. (2020) · Annals of Neurology · doi:10.1002/ana.25697 · Cited by 134 · see citing works

Migraine review for general practice

Aguilar-Shea, A. L., Membrilla, J. A., & de Terán, J. D. (2021) · Atención Primaria · doi:10.1016/j.aprim.2021.102208 · Cited by 131 · see citing works

Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives

Mungoven, T. J., Henderson, L. A., & Meylakh, N. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.705276 · Cited by 131 · see citing works

Animal models of migraine and experimental techniques used to examine trigeminal sensory processing

Harriott, A. M., Strother, L. C., Vila‐Pueyo, M., & Holland, P. R. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-1043-7 · Cited by 125 · see citing works

Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments

Zobdeh, F., Kraiem, A. B., Attwood, M. M., Chubarev, V. N., Tarasov, V. V., Schiöth, H. B., & Mwinyi, J. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15657 · Cited by 128 · see citing works

Central Sensitization in Migraine: A Narrative Review

Suzuki, K., Suzuki, S., Shiina, T., Kobayashi, S., & Hirata, K. (2022) · Journal of Pain Research · doi:10.2147/jpr.s329280 · Cited by 124 · see citing works

Targeted 5-HT1F Therapies for Migraine

Vila‐Pueyo, M. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0615-6 · Cited by 120 · see citing works

Therapeutic novelties in migraine: new drugs, new hope?

Do, T. P., Guo, S., & Ashina, M. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-0974-3 · Cited by 118 · see citing works

Current Prophylactic Medications for Migraine and Their Potential Mechanisms of Action

Sprenger, T., Viana, M., & Tassorelli, C. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0621-8 · Cited by 119 · see citing works

Is selective 5-HT 1F receptor agonism an entity apart from that of the triptans in antimigraine therapy?

Rubio‐Beltrán, E., Labastida‐Ramírez, A., Villalón, C. M., & MaassenVanDenBrink, A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.005 · Cited by 118 · see citing works

The Molecular Fingerprint of Dorsal Root and Trigeminal Ganglion Neurons

Lopes, D. M., Denk, F., & McMahon, S. B. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00304 · Cited by 115 · see citing works

Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study

Lee, M. J., Park, B., Cho, S., Kim, S. T., Park, H., & Chung, C. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-0986-z · Cited by 116 · see citing works

Risk factors for migraine disease progression: a narrative review for a patient-centered approach

Lipton, R. B., Buse, D. C., Nahas, S. J., Tietjen, G. E., Martin, V. T., Löf, E., Brevig, T., Cady, R. K., & Diener, H. (2023) · Journal of Neurology · doi:10.1007/s00415-023-11880-2 · Cited by 114 · see citing works

Recommendations on the Use of Anti‐CGRP Monoclonal Antibodies in Children and Adolescents

Szperka, C. L., VanderPluym, J. H., Orr, S. L., Oakley, C. B., Qubty, W. F., Patniyot, I. R., Lagman‐Bartolome, A. M., Morris, C., Gautreaux, J. R., Victorio, M. C., et al. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13414 · Cited by 112 · see citing works

Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity

Akerman, S., Karsan, N., Bose, P. R., Hoffmann, J., Holland, P. R., Romero‐Reyes, M., & Goadsby, P. J. (2018) · Brain · doi:10.1093/brain/awy313 · Cited by 112 · see citing works

Cluster headache pathophysiology — insights from current and emerging treatments

Wei, D. Y., & Goadsby, P. J. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00477-w · Cited by 112 · see citing works

Distribution of CGRP and CGRP receptor components in the rat brain

Warfvinge, K., & Edvinsson, L. I. (2017) · Cephalalgia · doi:10.1177/0333102417728873 · Cited by 107 · see citing works

An fMRI-based neural marker for migraine without aura

Tu, Y., Zeng, F., Lan, L., Li, Z., Maleki, N., Liu, B., Chen, J., Wang, C., Park, J., Lang, C., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000008962 · Cited by 109 · see citing works

Peripheral and central nervous system distribution of the CGRP neutralizing antibody [ 125 I] galcanezumab in male rats

Johnson, K. W., Morin, S. M., Wroblewski, V. J., & Johnson, M. P. (2019) · Cephalalgia · doi:10.1177/0333102419844711 · Cited by 107 · see citing works

Pathophysiological Bases of Comorbidity in Migraine

Altamura, C., Corbelli, I., de Tommaso, M., Lorenzo, C. D., Lorenzo, G. D., Renzo, A. D., Filippi, M., Jannini, T. B., Messina, R., Parisi, P., et al. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.640574 · Cited by 110 · see citing works

Headache associated with COVID-19: Frequency, characteristics and association with anosmia and ageusia

Rocha‐Filho, P. A. S., & Magalhães, J. E. (2020) · Cephalalgia · doi:10.1177/0333102420966770 · Cited by 104 · see citing works

Structural and Functional Brain Changes in Migraine

Ashina, S., Bentivegna, E., Martelletti, P., & Eikermann‐Haerter, K. (2021) · Pain and Therapy · doi:10.1007/s40122-021-00240-5 · Cited by 104 · see citing works

Targeted CGRP Small Molecule Antagonists for Acute Migraine Therapy

Holland, P. R., & Goadsby, P. J. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0617-4 · Cited by 102 · see citing works

Antidepressants for Preventive Treatment of Migraine

Burch, R. C. (2019) · Current Treatment Options in Neurology · doi:10.1007/s11940-019-0557-2 · Cited by 108 · see citing works

β-blockers: Their new life from hypertension to cancer and migraine

Fumagalli, C., Maurizi, N., Marchionni, N., & Fornasari, D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104587 · Cited by 102 · see citing works

The CGRP Pathway in Migraine as a Viable Target for Therapies

Edvinsson, L. I. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13305 · Cited by 101 · see citing works

Current understanding of cortical structure and function in migraine

Tolner, E. A., Chen, S., & Eikermann‐Haerter, K. (2019) · Cephalalgia · doi:10.1177/0333102419840643 · Cited by 101 · see citing works

On-demand cell-autonomous gene therapy for brain circuit disorders

Qiu, Y., O’Neill, N., Maffei, B., Zourray, C., Almacellas‐Barbanoj, A., Carpenter, J. C., Jones, S. P., Leite, M., Turner, T. J., Moreira, F. C., et al. (2022) · Science · doi:10.1126/science.abq6656 · Cited by 101 · see citing works

Debate: differences and similarities between tension-type headache and migraine

Onan, D., Younis, S., Wells-Gatnik, W. D., Farham, F., Andruškevičius, S., Abashidze, A., Jusupova, A., Romanenko, Y., Grosu, O., Moldokulova, M. Z., et al. (2023) · The Journal of Headache and Pain · doi:10.1186/s10194-023-01614-0 · Cited by 108 · see citing works

Non-invasive dural stimulation in mice: A novel preclinical model of migraine

Burgos-Vega, C., Quigley, L. D., Trevisan, G., Yan, F., Asiedu, M. N., Jacobs, B. A., Motina, M., Safdar, N., Yousuf, H., Avona, A., et al. (2018) · Cephalalgia · doi:10.1177/0333102418779557 · Cited by 96 · see citing works

Peripherally administered calcitonin gene–related peptide induces spontaneous pain in mice: implications for migraine

Rea, B. J., Wattiez, A., Waite, J. S., Castonguay, W. C., Schmidt, C. M., Fairbanks, A. M., Robertson, B. R., Brown, C. J., Mason, B. N., Moldovan-Loomis, M.-C., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001337 · Cited by 95 · see citing works

Interim results of a prospective, randomized, open-label, Phase 3 study of the long-term safety and efficacy of lasmiditan for acute treatment of migraine (the GLADIATOR study)

Brandes, J. L., Klise, S. R., Krege, J. H., Case, M. G., Khanna, R., Vasudeva, R., Raskin, J., Pearlman, E. M., & Kudrow, D. (2019) · Cephalalgia · doi:10.1177/0333102419864132 · Cited by 94 · see citing works

Sex and Gender Considerations in Episodic Migraine

Ahmad, S., & Rosendale, N. (2022) · Current Pain and Headache Reports · doi:10.1007/s11916-022-01052-8 · Cited by 94 · see citing works

Side effects associated with current and prospective antimigraine pharmacotherapies

González‐Hernández, A., Marichal‐Cancino, B. A., MaassenVanDenBrink, A., & Villalón, C. M. (2017) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1416097 · Cited by 93 · see citing works

Abnormal visuo-vestibular interactions in vestibular migraine: a cross sectional study

Bednarczuk, N. F., Bonsu, A., Ortega, M. C., Fluri, A., Chan, J., Rust, H. M., de Melo, F., Sharif, M., Seemungal, B. M., Golding, J. F., et al. (2018) · Brain · doi:10.1093/brain/awy355 · Cited by 93 · see citing works

Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients

García‐Azorín, D., Layos-Romero, A., Porta-Etessam, J., Membrilla, J. A., Caronna, E., González‐Martínez, A., Mencía, Á. S., Segura, T., González-García, N., de Terán, J. D., et al. (2022) · Cephalalgia · doi:10.1177/03331024211068074 · Cited by 94 · see citing works

Imaging the Visual Network in the Migraine Spectrum

Puledda, F., Ffytche, D. H., O’Daly, O., & Goadsby, P. J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01325 · Cited by 90 · see citing works

Targeting CGRP for the Prevention of Migraine and Cluster Headache: A Narrative Review

Yuan, H., Spare, N. M., & Silberstein, S. D. (2019) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13583 · Cited by 89 · see citing works

Nutrients to Improve Mitochondrial Function to Reduce Brain Energy Deficit and Oxidative Stress in Migraine

Fila, M., Chojnacki, C. J., Chojnacki, J., & Błasiak, J. (2021) · Nutrients · doi:10.3390/nu13124433 · Cited by 89 · see citing works

CGRP and migraine: from bench to bedside

Edvinsson, L. I. (2021) · Revue Neurologique · doi:10.1016/j.neurol.2021.06.003 · Cited by 88 · see citing works

Probiotics: Current Landscape and Future Horizons

Day, R. L., Harper, A. J., Woods, R. M., Davies, O. G., & Heaney, L. M. (2019) · Future Science OA · doi:10.4155/fsoa-2019-0004 · Cited by 88 · see citing works

Triptans and CGRP blockade – impact on the cranial vasculature

Benemei, S., Cortese, F., Labastida‐Ramírez, A., Marchese, F., Pellesi, L., Romoli, M., Vollesen, A. L. H., Lampl, C., & Ashina, M. (2017) · The Journal of Headache and Pain · doi:10.1186/s10194-017-0811-5 · Cited by 84 · see citing works

The Role of Magnesium in Pathophysiology and Migraine Treatment

Dolati, S., Rikhtegar, R., Mehdizadeh, A., & Yousefi, M. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01931-z · Cited by 84 · see citing works

Structural and functional footprint of visual snow syndrome

Schankin, C. J., Maniyar, F., Chou, D. E., Eller, M., Sprenger, T., & Goadsby, P. J. (2020) · Brain · doi:10.1093/brain/awaa053 · Cited by 83 · see citing works

Current and novel insights into the neurophysiology of migraine and its implications for therapeutics

Akerman, S., Romero‐Reyes, M., & Holland, P. R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.12.005 · Cited by 65 · see citing works

Bench to bedside understanding of migraine pathophysiology

Goadsby, P. J. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.118000 · Cited by 1 · see citing works

Pathophysiology of Migraine Disorder

Mueller, B. R., Diaz, N. A., & Grant, J. (2021) · Springer eBooks · doi:10.1007/978-3-030-75239-2_2 · Cited by 1 · see citing works

Pathophysiology of Migraine

Recober, A. (2021) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000983 · Cited by 35 · see citing works

Migraine pathogenesis and state of pharmacological treatment options

Sprenger, T., & Goadsby, P. J. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-71 · Cited by 100 · see citing works