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Factor XI Activation in a Revised Model of Blood Coagulation
Abstract
Coagulation factor XI is activated in vitro by factor XIIa in the presence of high molecular weight kininogen (HMWK) and a negatively charged surface. Factor XII deficiency is not associated with bleeding, which suggests that another mechanism for factor XI activation exists in vivo. A revised model of coagulation is proposed in which factor XI is activated by thrombin. In the absence of cofactors, thrombin is more effective ( k cat K m = 1.6 × 10 5 ) than factor XIIa (1.7 × 10 4 ) in activating factor XI. Dextran sulfate enhances activation of factor XI by thrombin 2000-fold; part of this effect is due to autoactivation of factor XI by activated factor XI.
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Citations
Cited by
Mechanisms of Thrombus Formation
Furie, B., & Furie, B. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801082 · Cited by 1,926
A Cell-based Model of Hemostasis
Monroe, D., & Hoffman, M. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615947 · Cited by 1,542
Thrombin activation of the factor XI dimer is a multi-staged process for each subunit
Barroeta, A. B., Albanese, P., Marquart, J. A., Meijers, J. C. M., & Scheltema, R. A. (2023) · doi:10.1101/2023.02.11.528103 · Cited by 1
Metadata
- Authors
- Gailani, D., & Broze, G. J.
- Venue
- Science
- Published
- 1991-08-23
- Volume
- 253
- Issue
- 5022
- Pages
- 909-912
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031677121
- Cited by
- 775
- References
- 0
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gailani, D., & Broze, G. J. (1991). Factor XI Activation in a Revised Model of Blood Coagulation. Science. https://doi.org/10.1126/science.1652157
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
