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Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
Abstract
The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30-base pair DNA sequence shows that the DNA is bent by 90°. This bend results almost entirely from two 40° kinks that occur between TG/CA base pairs at positions 5 and 6 on each side of the dyad axis of the complex. DNA sequence discrimination by CAP derives both from sequence-dependent distortion of the DNA helix and from direct hydrogen-bonding interactions between three protein side chains and the exposed edges of three base pairs in the major groove of the DNA. The structure of this transcription factor—DNA complex provides insights into possible mechanisms of transcription activation.
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Cited by
Crystal structure of a yeast TBP/TATA-box complex
Kim, Y., Geiger, J. H., Hahn, S., & Sigler, P. B. (1993) · Nature · doi:10.1038/365512a0 · Cited by 1,084
Schwabe, J. W. R., Chapman, L., Finch, J. T., & Rhodes, D. (1993) · Cell · doi:10.1016/0092-8674(93)90390-c · Cited by 750
A structural taxonomy of DNA-binding domains
Harrison, S. C. (1991) · Nature · doi:10.1038/353715a0 · Cited by 608
Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA
Beese, L. S., Derbyshire, V., & Steitz, T. A. (1993) · Science · doi:10.1126/science.8469987 · Cited by 474
Self-citationFold Change in Evolution of Protein Structures
Grishin, N. V. (2001) · Journal of Structural Biology · doi:10.1006/jsbi.2001.4335 · Cited by 444
Metadata
- Authors
- Schultz, S. C., Shields, G. C., & Steitz, T. A.
- Venue
- Science
- Published
- 1991-08-30
- Volume
- 253
- Issue
- 5023
- Pages
- 1001-1007
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2098089372
- Cited by
- 1,102
- References
- 0
- FWCI
- 27.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°. https://app.cochat.ai/papers/10.1126/science.1653449
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- Schultz, S. C., Shields, G. C., & Steitz, T. A. (1991). Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°. Science. https://doi.org/10.1126/science.1653449
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