The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Functional Modulation of Brain Sodium Channels by Protein Kinase C Phosphorylation
Abstract
Voltage-gated sodium channels, which are responsible for the generation of action potentials in the brain, are phosphorylated by protein kinase C (PKC) in purified form. Activation of PKC decreases peak sodium current up to 80 percent and slows its inactivation for sodium channels in rat brain neurons and for rat brain type IIA sodium channel α subunits heterologously expressed in Chinese hamster ovary cells. These effects are specific for PKC because they can be blocked by specific peptide inhibitors of PKC and can be reproduced by direct application of PKC to the cytoplasmic surface of sodium channels in excised inside-out membrane patches. Modulation of brain sodium channels by PKC is likely to have important effects on signal transduction and synaptic transmission in the central nervous system.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
From Ionic Currents to Molecular Mechanisms
Catterall, W. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)81133-2 · Cited by 2,118
Self-citationA cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.
West, J. W., Patton, D. E., Scheuer, T., Wang, Y., Goldin, A. L., & Catterall, W. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10910 · Cited by 830
Self-citationMechanisms of hyperalgesian and morphine tolerance: a current view of their possible interactions
Mao, J., Price, D. D., & Mayer, D. J. (1995) · Pain · doi:10.1016/0304-3959(95)00073-2 · Cited by 818
Persistent Sodium Current in Mammalian Central Neurons
Crill, W. E. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.002025 · Cited by 632
Metadata
- Authors
- Numann, R., Catterall, W. A., & Scheuer, T.
- Venue
- Science
- Published
- 1991-10-04
- Volume
- 254
- Issue
- 5028
- Pages
- 115-118
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2007289876
- Cited by
- 326
- References
- 1
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
